- Icewind DaleReleased: June 29, 2000Developer: Black Isle Studios
- Dragon Quest VIIReleased: August 26, 2000Developer: Heartbeat
- Carnivores Ice AgeReleased: December 19, 2000Developer: Action Forms
- Never 7: The End of InfinityReleased: December 21, 2000Series: Infinity
- God FieldReleased: 2001Platforms: web browser, Android
- Majesty: The Fantasy Kingdom SimReleased: 2001Developer: Cyberlore Studios
- Phoenix Wright: Ace AttorneyReleased: 2001Developer: Capcom
- RuneScapeReleased: January 4, 2001Developer: Jagex
- Sayonara O OshieteReleased: March 2, 2001Publisher: CRAFTWORK
- Spy Fox 3: "Operation Ozone"Released: March 30, 2001Developer: Humongous Entertainment
- BejeweledReleased: May 30, 2001Series: Bejeweled
- Freddi Fish 5: The Case of the Creature of Coral CoveReleased: June 19, 2001Developer: Humongous Entertainment
- Grand Theft Auto IIIReleased: October 23, 2001Series: Grand Theft Auto
- Oddworld: Munch's OddyseeReleased: November 15, 2001Developer: Oddworld Inhabitants
- RezReleased: November 22, 2001Developer: Sonic Team
- Max PayneReleased: December 12, 2001Series: Max Payne
- Sonic AdvanceReleased: December 20, 2001Developer: Sonic Team, Dimps
- Phoenix Wright: Ace Attorney – Justice for AllReleased: 2002Developer: Capcom
- SyberiaReleased: January 9, 2002Series: Syberia
- Final Fantasy XIReleased: May 16, 2002Developer: Square
- Super Monkey Ball 2Released: August 25, 2002Developer: Amusement Vision
- Ever 17: The Out of InfinityReleased: August 29, 2002Series: Infinity
- Grand Theft Auto: Vice CityReleased: October 29, 2002Series: Grand Theft Auto
- Alex the Allegator 4Released: 2003Platforms: Microsoft Windows, macOS, Linux, BeOS, Android
- Legion GoldReleased: 2003Developer: Slitherine Software UK Limited
- Siberian StrikeReleased: 2003Platforms: mobile phone, Android
- Star Wars: Knights of the Old RepublicReleased: 2003Developer: Bioware
- Neighbours from HellReleased: June 20, 2003Developer: JoWooD Entertainment
- Final Fantasy Crystal ChroniclesReleased: August 8, 2003Developer: The Game Designers Studio
- Majokko a la ModeReleased: August 29, 2003Platforms: Microsoft Windows, Android
- Fate/stay nightReleased: 2004Developer: Type‐Moon
- Pilot Brothers 3: Back Side of the EarthReleased: 2004Developer: K-D Lab
- Pixeline: Hotel SkrottenborgReleased: 2004Developer: Studio 1-2
- Phoenix Wright: Ace Attorney – Trials and TribulationsReleased: January 23, 2004Developer: Capcom
- Remember 11: The Age of InfinityReleased: March 18, 2004Series: Infinity
- Syberia IIReleased: March 30, 2004Series: Syberia
- CSI: MiamiReleased: April 24, 2004Developer: Radical Entertainment, Gameloft
- ClannadReleased: April 28, 2004Developer: Key, Visual Arts
- Neighbours from Hell 2: On VacationReleased: May 5, 2004Developer: JoWooD Entertainment
- Rome: Total WarReleased: September 22, 2004Developer: Creative Assembly, Feral Interactive
- The Bard's TaleReleased: October 26, 2004Developer: InXile entertainment
- Bejeweled 2Released: November 5, 2004Series: Bejeweled
- Asphalt: Urban GTReleased: November 15, 2004Developer: Gameloft
- Half-Life 2Released: November 16, 2004Developer: Valve Corporation
- Dragon Quest VIIIReleased: November 27, 2004Developer: Level-5
- Resident Evil 4Released: January 11, 2005Developer: Capcom
- Oddworld: Stranger's WrathReleased: January 25, 2005Developer: Oddworld Inhabitants
- Star Wars Knights of the Old Republic II: The Sith LordsReleased: February 8, 2005Developer: Obsidian Entertainment, Aspyr
- Sonic JumpReleased: February 21, 2005Developer: Sonic Team
- Jade EmpireReleased: April 12, 2005Developer: Bioware
- LuxorReleased: May 30, 2005Developer: MumboJumbo
- Espgaluda IIReleased: November 25, 2005Developer: CAVE
- Riviera: The Promised LandReleased: 2006Developer: Sting
- Valkyrie Profile: LennethReleased: March 2, 2006Developer: Tri-Ace
- Yggdra UnionReleased: March 23, 2006Developer: Sting
- Hitman: Blood MoneyReleased: May 30, 2006Developer: Feral Interactive
- Rome: Total War: AlexanderReleased: June 19, 2006Developer: Creative Assembly, Feral Interactive
- Titan QuestReleased: June 26, 2006Developer: Iron Lore Entertainment
- Adventure Bar StoryReleased: August 3, 2006Platforms: Microsoft Windows, PlayStation Portable, mobile phone, Nintendo 3DS, Android
- TetrisReleased: September 12, 2006Developer: EA Mobile
- BullyReleased: October 27, 2006Developer: Rockstar New England, Rockstar Toronto, Rockstar Vancouver
- Bible BlackReleased: November 21, 2006Developer: Active Soft
- Military MadnessReleased: December 18, 2006Developer: Hudson Soft
- The Blackwell LegacyReleased: December 23, 2006Developer: Wadjet Eye Games
- AkinatorReleased: 2007Platforms: Microsoft Windows, macOS, BlackBerry, Linux, Windows Phone, web browser, Android
- Prince of Persia ClassicReleased: 2007Developer: Gameloft
- Professor Layton and the Curious VillageReleased: February 15, 2007Developer: Level-5
- The Impossible QuizReleased: February 20, 2007Developer: Splapp-me-do, InXile entertainment
- PeggleReleased: February 27, 2007Publisher: Valve Corporation
- Powder GameReleased: April 7, 2007Platforms: web browser, Android
- Apollo Justice: Ace AttorneyReleased: April 12, 2007Developer: Capcom
- Final Fantasy Tactics: The War of the LionsReleased: May 10, 2007Developer: Tose Co.
- Blackwell UnboundReleased: September 4, 2007Developer: Wadjet Eye Games
- Record of Agarest WarReleased: September 27, 2007Developer: Idea Factory
- SupercowReleased: September 28, 2007Developer: Nevosoft
- PortalReleased: October 10, 2007Developer: Valve Corporation
- DeathsmilesReleased: October 19, 2007Developer: Degica, CAVE
- Mystery Case Files: Madame FateReleased: November 7, 2007Developer: Big Fish Games
- Final Fantasy IVReleased: December 20, 2007Developer: Square Enix
- Chaos;HeadReleased: 2008Developer: 5pb. Inc.
- Farm Frenzy 2Released: 2008Developer: Melsoft Games
- The Powder ToyReleased: 2008Platforms: Microsoft Windows, macOS, Linux, Android
- Devil May Cry 4Released: January 31, 2008Developer: Capcom
- Assassin's Creed: Altaïr's ChroniclesReleased: February 5, 2008Developer: Gameloft
- Final Fantasy IV: The After YearsReleased: February 18, 2008Developer: Matrix Software
- 12Riven: The Psi-Climinal of IntegralReleased: March 13, 2008Series: Infinity
- Lego Star Wars: The Complete SagaReleased: March 27, 2008Developer: Traveller's Tales, Feral Interactive
- The World Ends with YouReleased: April 18, 2008Developer: Square Enix, Jupiter, H.a.n.d.
- KunitoriReleased: April 25, 2008Publisher: One Compath, Mynet
- Dodonpachi ResurrectionReleased: May 22, 2008Developer: CAVE
- Tap Tap RevengeReleased: July 11, 2008Developer: Tapulous
- Knights in the NightmareReleased: September 25, 2008Developer: Sting
- De BlobReleased: September 30, 2008Developer: THQ Nordic, Universomo, Ronimo Games, Blue Tongue Entertainment
- Secret of ManaReleased: October 13, 2008Developer: Square
- Mystery Case Files: Return to RavenhearstReleased: November 26, 2008Developer: Big Fish Games
- TouchgrindReleased: November 26, 2008Developer: Illusion Labs
- 428: Shibuya ScrambleReleased: December 4, 2008Developer: Chunsoft
- Spy Fox in "Dry Cereal"Released: December 5, 2008Developer: Humongous Entertainment
- Sōshinjutsu 3Released: December 12, 2008Platforms: Microsoft Windows, Android
- I Love KatamariReleased: December 14, 2008Developer: Namco