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- Wacky RacesReleased: June 30, 2000Platforms: Game Boy Color
- Dokapon MillenniumQuestReleased: July 14, 2000Developer: Asmik Ace Entertainment
- Dungeon SaviorReleased: August 4, 2000Publisher: J-Wing
- Zok Zok HeroesReleased: August 4, 2000Developer: KAZe
- Kirby Tilt 'n' TumbleReleased: August 23, 2000Developer: HAL Laboratory
- Perfect DarkReleased: August 28, 2000Developer: Rare Ltd.
- Gobs of GamesReleased: September 2000Developer: 2n Productions
- Pokémon Puzzle ChallengeReleased: September 21, 2000Developer: Intelligent Systems
- Beatmania GB GatchaMIX2Released: September 28, 2000Series: Beatmania
- Elevator Action EXReleased: September 29, 2000Developer: Altron
- Cruis'n ExoticaReleased: October 16, 2000Developer: Midway Games
- Mega Man XtremeReleased: October 20, 2000Developer: Capcom
- Tweety's High-Flying AdventureReleased: November 2000Platforms: Game Boy Color
- Mario TennisReleased: November 1, 2000Series: Mario Tennis
- Keitai Denjū Telefang: Power VersionReleased: November 3, 2000Developer: Winning Entertainment Group
- Keitai Denjū Telefang: Speed VersionReleased: November 3, 2000Developer: Winning Entertainment Group
- Test Drive Le MansReleased: November 8, 2000Developer: Atari, Krome Studios Melbourne, Eutechnyx
- Tales of Phantasia: Narikiri DungeonReleased: November 10, 2000Developer: Namco Tales Studio
- Airforce DeltaReleased: November 21, 2000Platforms: Game Boy Color
- Pop'n Music Mickey TunesReleased: November 22, 2000Developer: Konami
- Test Drive 2001Released: November 28, 2000Series: Test Drive
- MerlinReleased: December 2000Developer: RFX Interactive
- NBA Jam 2001Released: December 5, 2000Platforms: Game Boy Color
- Heroes of Might and Magic IIReleased: December 7, 2000Series: Heroes of Might and Magic
- Robot Wars: Metal MayhemReleased: December 7, 2000Developer: Tiertex Design Studios
- Pokémon CrystalReleased: December 14, 2000Developer: Game Freak
- Ganbare Goemon: Hoshizorashi Dynamites Arawaru!!Released: December 21, 2000Developer: Konami
- Grandia: Parallel TrippersReleased: December 22, 2000Developer: Game Arts
- The Lion King: Simba's Mighty AdventureReleased: December 22, 2000Publisher: Disney Interactive Studios
- Warriors of Might and MagicReleased: December 22, 2000Developer: The 3DO Company
- Aliens: Thanatos EncounterReleased: 2001Developer: Crawfish Interactive
- Chee-Chai AlienReleased: 2001Developer: Creatures
- Cross HunterReleased: 2001Developer: Fonfun
- Das Geheimnis der Happy Hippo-InselReleased: 2001Developer: Kritzelkratz 3000 GmbH
- DT: Lords of GenomesReleased: 2001Platforms: Game Boy, Game Boy Color
- Keep the Balance!Released: 2001Platforms: Game Boy Color
- LEGO Island 2: The Brickster's RevengeReleased: 2001Platforms: Game Boy Color
- Planet of the ApesReleased: 2001Developer: Visiware, Torus Games
- Santa Claus JuniorReleased: 2001Platforms: Game Boy Color
- The Nations: Land of LegendsReleased: 2001Developer: Neon Studios
- Top Gun: FirestormReleased: 2001Platforms: Game Boy Color
- Xena: Warrior PrincessReleased: 2001Platforms: Game Boy Color
- Croc 2Released: January 23, 2001Developer: Winning Entertainment Group
- Action Man: Search for Base XReleased: February 6, 2001Developer: Winning Entertainment Group
- Mary-Kate and Ashley: Winners CircleReleased: February 27, 2001Developer: Tantalus Media
- The Legend of Zelda: Oracle of SeasonsReleased: February 27, 2001Developer: Capcom, Flagship
- The Legend of Zelda: Oracle of Seasons and Oracle of AgesReleased: February 27, 2001Developer: Capcom, Flagship
- 3D Pocket PoolReleased: March 2001Platforms: Game Boy Color
- Dragon Warrior Monsters 2Released: March 9, 2001Developer: Tose Co.
- Doraemon: Kimi to Pet no MonogatariReleased: March 16, 2001Platforms: Game Boy Color
- Tech Deck SkateboardingReleased: March 26, 2001Platforms: Game Boy Color
- The Simpsons: Night of the Living Treehouse of HorrorReleased: March 26, 2001Developer: Software Creations
- Pokémon Card GB2: Here Comes Team GR!Released: March 28, 2001Developer: Hudson Soft
- Extreme GhostbustersReleased: April 2, 2001Platforms: Game Boy Color
- Mobile GolfReleased: May 11, 2001Developer: Camelot Software Planning
- The Legend of Zelda: Oracle of AgesReleased: May 13, 2001Developer: Capcom, Flagship
- Alone in the Dark: The New NightmareReleased: May 18, 2001Developer: Darkworks
- Spider-Man 2: The Sinister SixReleased: May 30, 2001Developer: Torus Games
- Rayman 2Released: June 2001Platforms: Game Boy Color
- Atlantis: The Lost EmpireReleased: June 14, 2001Platforms: Game Boy Color
- Star Ocean: Blue SphereReleased: June 28, 2001Developer: Tri-Ace
- Tomb Raider: Curse of the SwordReleased: July 1, 2001Developer: Core Design
- The Land Before TimeReleased: July 14, 2001Platforms: Game Boy Color
- Mega Man Xtreme 2Released: July 19, 2001Developer: Capcom
- Shiren the Wanderer GB2: Magic Castle of the DesertReleased: July 19, 2001Developer: Chunsoft
- Dragon's LairReleased: August 24, 2001Series: Dragon's Lair
- Game Boy Wars 3Released: August 30, 2001Series: Wars
- Hands of TimeReleased: October 2001Developer: Mirage Media S.C.
- Dracula: Crazy VampireReleased: October 9, 2001Publisher: DreamCatcher Interactive
- Tony Hawk's Pro Skater 3Released: October 28, 2001Developer: Gearbox Software, Shaba Games, Edge of Reality, HotGen, Neversoft
- Kelly Club: Clubhouse FunReleased: October 31, 2001Platforms: Game Boy Color
- Harry Potter and the Philosopher's StoneReleased: November 16, 2001Developer: Griptonite Games
- Resident Evil GaidenReleased: December 14, 2001Developer: Capcom
- Bear in the Big Blue HouseReleased: 2002Platforms: Game Boy Color
- Hugo: The Evil MirrorReleased: 2002Developer: Interactive Television Entertainment
- Yu-Gi-Oh! Dark Duel StoriesReleased: March 2002Platforms: Game Boy Color
- Monster TravelerReleased: March 8, 2002Platforms: Game Boy Color
- Harry Potter and the Chamber of SecretsReleased: November 5, 2002Developer: KnowWonder
- Taxi 3Released: January 30, 2003Platforms: Microsoft Windows, Nintendo GameCube, Game Boy Color
- Toki ToriReleased: January 29, 2010Developer: Two Tribes
- Harvest Moon 2Released: January 25, 2012Developer: Victor Interactive Software
- Harvest Moon 3Released: January 25, 2012Developer: Victor Interactive Software
- Mario GolfReleased: October 11, 2012Platforms: Game Boy Color
- Dragon QuestReleased: September 27, 2019Developer: Chunsoft
- Carl Lewis Athletics 2000Released: September 2020Platforms: Game Boy Color
- BULB!Released: February 10, 2021Platforms: Game Boy Color
- Ruby & Rusty – Save the CrowsReleased: September 30, 2021Platforms: Game Boy, Game Boy Color
- Swordbird Song: The Iron Owl TowerReleased: December 20, 2021Engine: GB Studio
- Supermarket Spree DXReleased: 2023Engine: GB Studio
- ShantaeReleased: June 2, 2023Developer: WayForward Technologies
- Super JetPak DXReleased: August 29, 2023Platforms: Game Boy, Game Boy Color
- Toki Tori: Ultimate EditionReleased: 2024Developer: Two Tribes
- Army Men 2Series: Army MenPlatforms: Game Boy Color
- Bakusou Dekotora Densetsu GB Special: Otoko Dokyou no Tenka TouitsuSeries: Bakusō Dekotara DensetsuPlatforms: Game Boy Color
- Choro Q: Hyper Customable GBPublisher: TakaraPlatforms: Game Boy Color
- Commander KeenSeries: Commander KeenPlatforms: Game Boy Color
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- NHL Blades of Steel 2000Platforms: Game Boy ColorGenre: ice hockey video game
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