- BacteriaReleased: March 23, 2016Developer: Sometimes You
- Samorost 3Released: March 24, 2016Developer: Amanita Design, Jakub Dvorský
- Space Food TruckReleased: March 25, 2016Platforms: Microsoft Windows, macOS, Linux
- Age of Fear 2: The Chaos LordReleased: March 27, 2016Platforms: Microsoft Windows, macOS, Linux
- One Thousand LiesReleased: March 28, 2016Engine: Ren'Py
- The Abbey of Crime: ExtensumReleased: March 28, 2016Developer: Manuel Pazos, Daniel Celemín
- Angry Video Game Nerd II: ASSimilationReleased: March 29, 2016Developer: FreakZone Games
- Guns of InfinityReleased: March 29, 2016Developer: Hosted Games
- AdorablesReleased: March 30, 2016Publisher: Volens Nolens Games
- EpistoryReleased: March 30, 2016Publisher: PID Games
- HunieCam StudioReleased: April 4, 2016Developer: HuniePotDev
- Age of Conquest IVReleased: April 5, 2016Engine: libGDX
- Enter the GungeonReleased: April 5, 2016Developer: Dodge Roll
- Tibetan Quest: Beyond the World's EndReleased: April 7, 2016Developer: Brave Giant
- Automata EmpireReleased: April 8, 2016Platforms: Microsoft Windows, macOS, Linux
- StarsOneReleased: April 8, 2016Platforms: Microsoft Windows, macOS, Linux
- The Hero Project: Redemption SeasonReleased: April 8, 2016Developer: Choice of Games
- Marble VoidReleased: April 12, 2016Platforms: Microsoft Windows, Linux
- Gravity DenReleased: April 15, 2016Publisher: Volens Nolens Games
- Demon's CrystalsReleased: April 21, 2016Platforms: Microsoft Windows, macOS, Linux
- Mythic Wonders: The Philosopher's StoneReleased: April 21, 2016Publisher: Artifex Mundi
- Best of UsReleased: April 22, 2016Developer: Hosted Games
- Poly TownsReleased: April 22, 2016Platforms: Microsoft Windows, macOS, Linux
- The Sea EternalReleased: April 22, 2016Developer: Choice of Games
- Colours of Magic: Aqua TeeterReleased: April 25, 2016Developer: RunServer
- Corpse PartyReleased: April 25, 2016Developer: Team GrisGris
- Cornerstone: The Song of TyrimReleased: April 26, 2016Developer: Overflow
- Total War: WarhammerReleased: April 28, 2016Developer: Creative Assembly
- RogueBox AdventuresReleased: April 29, 2016Platforms: Microsoft Windows, Linux
- Selenon RisingReleased: April 29, 2016Publisher: Sekai Project
- GlitchspaceReleased: May 5, 2016Platforms: Microsoft Windows, macOS, Linux
- Doomsday on DemandReleased: May 6, 2016Developer: Hosted Games
- EcotoneReleased: May 6, 2016Developer: Sundae Factory
- Gunmetal Arcadia ZeroReleased: May 6, 2016Developer: Minor Key Games
- Princess Isabella: The Rise of an HeirReleased: May 12, 2016Developer: Gogii Games
- Evo ExploresReleased: May 16, 2016Platforms: Microsoft Windows, macOS, Linux
- Space Pirates And Zombies 2Released: May 17, 2016Developer: MinMax Games Ltd.
- Youtubers LifeReleased: May 18, 2016Developer: U-Play Online
- ArkshotReleased: May 19, 2016Publisher: Digerati
- Choice of the PirateReleased: May 20, 2016Developer: Choice of Games
- Postal ReduxReleased: May 20, 2016Developer: Running with Scissors
- Siralim 2Released: May 27, 2016Developer: Thylacine Studios
- Planar ConquestReleased: May 30, 2016Developer: Wastelands Interactive
- Dead Island: Definitive CollectionReleased: May 31, 2016Platforms: Microsoft Windows, Linux
- Dead Island: Riptide Definitive EditionReleased: May 31, 2016Series: Dead Island
- The NADI ProjectReleased: June 2016Platforms: Microsoft Windows, macOS, Linux
- OxenfreeReleased: June 1, 2016Developer: Night School Studio
- A Game of ChangesReleased: June 2, 2016Engine: Godot
- Boyfriend to DeathReleased: June 3, 2016Engine: Ren'Py
- Dead Island: Definitive EditionReleased: June 3, 2016Series: Dead Island
- Home BehindReleased: June 3, 2016Developer: TPP Studio
- Dino Eggs: RebirthReleased: June 8, 2016Platforms: Microsoft Windows, macOS, Linux
- CreaReleased: June 9, 2016Platforms: Microsoft Windows, macOS, Linux
- Doodle KingdomReleased: June 9, 2016Developer: JoyBits
- Just BonesReleased: June 9, 2016Developer: Elephant Games
- Choice of AlexandriaReleased: June 10, 2016Developer: Choice of Games
- On Rusty TrailsReleased: June 13, 2016Developer: Black Pants Studio
- FeudalismReleased: June 14, 2016Publisher: IV Productions
- BitfighterReleased: June 15, 2016Platforms: Microsoft Windows, macOS, Linux
- Zaccaria PinballReleased: June 16, 2016Platforms: Microsoft Windows, macOS, Linux, Android, Xbox Series X and Series S
- 12 Labours of Hercules V: Kids of HellasReleased: June 17, 2016Developer: Jetdogs Studios, Zoom Out Games
- CursedReleased: June 17, 2016Developer: Jetdogs Studios
- Higurashi When They Cry Hou - Ch.3 TatarigoroshiReleased: June 17, 2016Developer: 07th Expansion
- Dungeon of gainReleased: June 23, 2016Publisher: Volens Nolens Games
- Earth Space ColoniesReleased: July 2016Platforms: Microsoft Windows, macOS, Linux
- Mouth SweetReleased: July 2, 2016Engine: RPG Maker 2003
- Haven MoonReleased: July 8, 2016Platforms: Microsoft Windows, macOS, Linux
- Lion QuestReleased: July 11, 2016Platforms: Microsoft Windows, macOS, Linux
- Poly BridgeReleased: July 12, 2016Developer: Dry Cactus
- Crush Your EnemiesReleased: July 13, 2016Developer: Vile Monarch
- Crime Secrets: Crimson LilyReleased: July 14, 2016Developer: One More Level
- Dead AgeReleased: July 14, 2016Publisher: Headup Games
- Bird of LightReleased: July 15, 2016Platforms: Microsoft Windows, macOS, Linux
- Empty HorizonsReleased: July 19, 2016Developer: ebi-hime
- BrainBread 2Released: July 20, 2016Developer: Reperio Studios
- Clock SimulatorReleased: July 20, 2016Platforms: Microsoft Windows, macOS, Linux
- Red Rope: Don't Fall BehindReleased: July 21, 2016Platforms: Microsoft Windows, macOS, Linux
- Lovely Planet ArcadeReleased: July 22, 2016Platforms: Microsoft Windows, macOS, Linux
- Sky to Fly: Soulless LeviathanReleased: July 22, 2016Developer: AIVIK LLC
- The Away TeamReleased: July 22, 2016Engine: SFML
- Just DesertsReleased: July 25, 2016Publisher: Sekai Project
- Steam SquadReleased: July 28, 2016Platforms: Microsoft Windows, macOS, Linux
- Axis Football 2016Released: July 29, 2016Platforms: Microsoft Windows, macOS, Linux
- Swamp CastleReleased: July 29, 2016Developer: Hosted Games
- Trials of AzraReleased: August 2016Platforms: Microsoft Windows, macOS, Linux
- This Is the PoliceReleased: August 2, 2016Publisher: THQ Nordic
- Tricky TowersReleased: August 2, 2016Developer: WeirdBeard
- Selma and the WispReleased: August 4, 2016Platforms: Microsoft Windows, macOS, Linux
- Frozen StateReleased: August 5, 2016Platforms: Microsoft Windows, macOS, Linux
- Random Access MurderReleased: August 5, 2016Platforms: Microsoft Windows, macOS, Linux
- Too Angry To SpaceReleased: August 8, 2016Platforms: Microsoft Windows, macOS, Linux
- Kingdom: New LandsReleased: August 9, 2016Publisher: Raw Fury
- Winter NovelReleased: August 10, 2016Platforms: Microsoft Windows, Linux
- Enigmatis 3: The Shadow of KarkhalaReleased: August 11, 2016Developer: Artifex Mundi
- ReignsReleased: August 11, 2016Developer: Nerial
- Miaou MoonReleased: August 16, 2016Platforms: Microsoft Windows, macOS, Linux
- Machinations: Fog of WarReleased: August 19, 2016Developer: Hosted Games
- Wish -tale of the sixteenth night of lunar month-Released: August 19, 2016Platforms: Microsoft Windows, macOS, Linux
- Crawlers and BrawlersReleased: August 22, 2016Engine: Microsoft XNA
- Deus Ex: Mankind DividedReleased: August 23, 2016Developer: Nixxes Software, Eidos Montreal, Feral Interactive