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- The Jackbox Party Pack 8Released: October 14, 2021Developer: Jackbox Games
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- InfraSpaceReleased: October 15, 2021Developer: Dionic Software
- Island of LustReleased: October 15, 2021Platforms: Microsoft Windows, macOS
- Love Duction! The Guide for Galactic LoversReleased: October 15, 2021Publisher: Sekai Project
- Pathological TiresReleased: October 15, 2021Platforms: Microsoft Windows, macOS, Linux
- Scale EnchanterReleased: October 15, 2021Platforms: Microsoft Windows, macOS
- Hidden TownReleased: October 16, 2021Platforms: Microsoft Windows, macOS, Linux
- Hidden WaterReleased: October 16, 2021Platforms: Microsoft Windows, macOS, Linux
- Tower AttackReleased: October 16, 2021Platforms: Microsoft Windows, macOS
- I Love Finding PupsReleased: October 17, 2021Platforms: Microsoft Windows, macOS
- Dual Souls: The Last BearerReleased: October 19, 2021Platforms: Microsoft Windows, macOS, Linux
- Escape SimulatorReleased: October 19, 2021Developer: Pine Studio
- InscryptionReleased: October 19, 2021Publisher: Devolver Digital
- NBA 2K22 Arcade EditionReleased: October 19, 2021Series: NBA 2K
- Youtubers Life 2Released: October 19, 2021Developer: U-Play Online
- Behind Closed Doors: A Developer's TaleReleased: October 20, 2021Publisher: Sometimes You
- JARSReleased: October 20, 2021Publisher: Daedalic Entertainment
- Rubicon: a conspiracy of silenceReleased: October 20, 2021Platforms: Microsoft Windows, macOS, Linux
- Demon Hunter 4: Riddles of LightReleased: October 21, 2021Developer: Brave Giant
- Luffy: Way Back HomeReleased: October 21, 2021Platforms: Microsoft Windows, macOS, Linux
- Toilet Flushing SimulatorReleased: October 21, 2021Platforms: Microsoft Windows, macOS, Linux
- AlisaReleased: October 22, 2021Platforms: Microsoft Windows, macOS, Linux, Xbox Series X and Series S
- Amazing Superhero SquadReleased: October 22, 2021Developer: Siberian Koala
- Dot's HomeReleased: October 22, 2021Platforms: Microsoft Windows, macOS
- FeignReleased: October 23, 2021Platforms: Microsoft Windows, macOS
- FlashlightReleased: October 25, 2021Platforms: Microsoft Windows, macOS
- Juro JanosikReleased: October 25, 2021Platforms: Microsoft Windows, macOS, Linux
- Franchise Hockey Manager 8Released: October 26, 2021Developer: Out of the Park Developments
- Too Many Zombies!Released: October 26, 2021Platforms: Microsoft Windows, macOS, Linux
- DadishReleased: October 27, 2021Developer: Thomas K. Young
- Rising ConstellationReleased: October 27, 2021Platforms: Microsoft Windows, macOS, Linux
- Gachi BirdReleased: October 28, 2021Platforms: Microsoft Windows, macOS
- Milli & GregReleased: October 28, 2021Developer: 2ndBoss
- Crab GameReleased: October 29, 2021Platforms: Microsoft Windows, macOS, Linux
- Hypnagogia: Boundless DreamsReleased: October 29, 2021Platforms: Microsoft Windows, macOS, Linux
- In SilenceReleased: October 29, 2021Platforms: Microsoft Windows, macOS
- Sky TaleReleased: November 2021Developer: FrostPeek Studio
- Push Puzzle - Rescue AdventureReleased: November 2, 2021Platforms: Microsoft Windows, macOS
- The Legend of TiandingReleased: November 2, 2021Developer: Neon Doctrine, Creative Games & Computer Graphics Corporation
- To The Rescue!Released: November 2, 2021Publisher: Freedom Games
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- BloodshoreReleased: November 3, 2021Platforms: Microsoft Windows, macOS, Xbox Series X and Series S
- FishardsReleased: November 3, 2021Platforms: Microsoft Windows, macOS, Linux
- Miasma: Citizens of Free ThoughtReleased: November 3, 2021Platforms: Microsoft Windows, macOS, Linux
- Schildmaid MXReleased: November 4, 2021Developer: HitP Studio
- Transformers: Tactical ArenaReleased: November 5, 2021Developer: Red Games Co.
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- Football Manager 2022Released: November 9, 2021Developer: Sports Interactive
- MavertaReleased: November 9, 2021Developer: My Label Game Studio
- Hyper EchelonReleased: November 10, 2021Platforms: Microsoft Windows, macOS
- ShillelaghReleased: November 10, 2021Platforms: Microsoft Windows, macOS
- Alchemic CutieReleased: November 11, 2021Platforms: Microsoft Windows, macOS, Linux
- BobokReleased: November 11, 2021Platforms: Microsoft Windows, macOS, Linux
- Kingdom of MavertaReleased: November 11, 2021Developer: My Label Game Studio
- Kingdom Rush Frontiers TD+Released: November 12, 2021Platforms: macOS
- Raiders of the Icepeak MountainsReleased: November 12, 2021Developer: Hosted Games
- Run, Kitty! - A Furry Gay Visual NovelReleased: November 12, 2021Platforms: Microsoft Windows, macOS, Linux
- Temple of Endless NightReleased: November 12, 2021Developer: Hosted Games
- A=BReleased: November 15, 2021Developer: Artless Games
- Pro Basketball Manager 2022Released: November 15, 2021Platforms: Microsoft Windows, macOS
- Marsupilami: HoobadventureReleased: November 16, 2021Platforms: Microsoft Windows, macOS
- Tavern MasterReleased: November 16, 2021Platforms: Microsoft Windows, macOS, Linux
- Arcadia FallenReleased: November 17, 2021Developer: Galdra Studios
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- Chao's Collection of Random GamesReleased: November 17, 2021Platforms: Microsoft Windows, macOS
- Maverta CityReleased: November 17, 2021Developer: My Label Game Studio
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- Novena DiabolosReleased: November 18, 2021Publisher: Giiku Games
- Cupid NonogramReleased: November 19, 2021Platforms: Microsoft Windows, macOS
- Hero of the Kingdom: The Lost Tales 2Released: November 19, 2021Developer: Lonely Troops
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- LaserboyReleased: November 22, 2021Platforms: Microsoft Windows, macOS, Linux
- Mystery Case Files: Incident at Pendle TowerReleased: November 23, 2021Developer: GrandMA Studios
- Cliffhanger: Challenger of TomorrowReleased: November 24, 2021Developer: Choice of Games
- Feral FlowersReleased: November 24, 2021Platforms: Microsoft Windows, macOS, Linux
- SGS Heia SafariReleased: November 25, 2021Publisher: Avalon Digital
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- Cubic DwellerReleased: November 26, 2021Platforms: Microsoft Windows, macOS
- Fatal PawsReleased: November 26, 2021Platforms: Microsoft Windows, macOS
- SnowTunes IslandReleased: December 2021Platforms: Microsoft Windows, macOS
- Faerie's Bargain: The Price of BusinessReleased: December 2, 2021Developer: Choice of Games
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- The CaptainReleased: December 3, 2021Platforms: Microsoft Windows, macOS, Linux
- Alone With YouReleased: December 4, 2021Platforms: Microsoft Windows, macOS, Linux
- SOTANO - Mystery Escape Room AdventureReleased: December 4, 2021Platforms: Microsoft Windows, macOS
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