- Ashland RevolutionReleased: 1981Platforms: Classic Mac OS
- Caverns of MarsReleased: 1981Publisher: Atari Program Exchange
- Cranston ManorSeries: Hi-Res AdventureReleased: 1981
- DefenderDeveloper: WMS IndustriesReleased: 1981
- FroggerDeveloper: KonamiReleased: 1981
- Happy HolidaysReleased: 1981Platforms: Intellivision
- Jump BugDeveloper: BanprestoReleased: 1981
- Lock 'n' ChaseDeveloper: Data EastReleased: 1981
- MarsReleased: 1981Platforms: arcade
- MeteorsReleased: 1981Platforms: arcade video game machine
- Monty Plays ScrabbleReleased: 1981Platforms: TRS-80, Apple II
- Obliterate!Released: 1981Genre: simulation video game, computer wargame
- Pool 1.5Released: 1981Platforms: Apple II
- Sky SkipperDeveloper: Nintendo Research & Development 1Released: 1981
- Space ArmadaDeveloper: APh Technological ConsultingReleased: 1981
- The EndReleased: 1981Platforms: Arcadia 2001, arcade video game machine
- Ulysses and the Golden FleeceSeries: Hi-Res AdventureReleased: 1981
- Zork IIDeveloper: InfocomSeries: Zork
- Asteroids DeluxeDeveloper: Atari, Inc.Released: March 1981
- CentipedeDeveloper: Atari, Inc.Released: June 1981
- Ultima I: The First Age of DarknessDeveloper: Richard GarriottSeries: Ultima
- Game & Watch: OctopusReleased: July 16, 1981Publisher: Nintendo
- Castle WolfensteinDeveloper: Muse SoftwareSeries: Wolfenstein
- Wizardry: Proving Grounds of the Mad OverlordDeveloper: Game Studio, Sir-TechSeries: Wizardry
- David's Midnight MagicReleased: December 1981Publisher: Atari Corporation, Ariolasoft UK, SystemSoft Alpha, Broderbund