| Mattel | 1945 | 2 | 3 |
| Maximum Games | 2009 | 1 | 4 |
| Maxis | 1987 | 40 | 6 |
| Mega Cat Studios | 2015 | 8 | 1 |
| Mentor InterActive (United States) | — | — | 1 |
| Meringue Interactive | — | 1 | 1 |
| Meta Platforms | July 29, 2004 | 1 | 2 |
| Metro3D | 1998 | — | 5 |
| Micro Magic Inc. | 1995 | 1 | — |
| MicroGraphic Image | 1983 | 1 | — |
| MicroPlay Software | August 1991 | — | 1 |
| MicroProse | 1982 | 21 | 22 |
| Microsoft | April 4, 1975 | 3 | 22 |
| Microsoft Casual Games | — | 1 | — |
| Midway Austin | March 23, 2000 | 3 | — |
| Midway Games | 1988 | 28 | 68 |
| Midway Home Entertainment | 1994 | — | 1 |
| Midway Studios San Diego | 2009 | — | — |
| Midway Studios – Los Angeles | 1994 | 4 | — |
| Military Simulations | 1994 | 1 | 1 |
| Mindscape | 1983 | 5 | 33 |
| Minnesota Educational Computing Consortium | 1973 | 6 | 3 |
| Minor Key Games | July 15, 2013 | 3 | 3 |
| Mischief | — | 1 | 1 |
| Mistwalker | 2004 | 1 | 1 |
| Modus Games | — | — | 18 |
| Mommy's Best Games | 2007 | 6 | 5 |
| Monkey Bar Games | 2005 | 2 | — |
| Monochrome, Inc | — | 3 | 3 |
| Monolith Productions | October 25, 1994 | 11 | 3 |
| Monomi Park | 2014 | 2 | 2 |
| Monster Games | 1996 | 7 | — |
| Moonshot Games | 2020 | 1 | — |
| Morningstar Game Studio | — | 2 | 1 |
| Motorsport Games | — | 3 | 3 |
| Moving Pieces Interactive | — | 2 | 2 |
| MTV | August 1981 | — | 4 |
| MTV Games | 2005 | — | 6 |
| MumboJumbo | 2001 | 29 | 16 |
| Muse Software | 1978 | 2 | 2 |
| Muzzy Lane | — | 2 | 2 |
| Myroid-Type Comics | — | 2 | 2 |
| Mythic Entertainment | 1995 | 2 | — |
| N-Fusion Interactive | 1998 | 3 | — |
| N-Space | 1994 | 15 | — |
| N3TWORK | 2013 | 1 | 1 |
| Namco Bandai Games America Inc. | — | — | 2 |
| Namco Hometek Inc. | 1990 | 1 | 1 |
| National Aeronautics and Space Administration | July 29, 1958 | — | 2 |
| National Basketball Association | August 3, 1949 | — | 1 |
| Naughty Dog | 1984 | 18 | 1 |
| Navarre Corporation | 1983 | — | 1 |
| Necrosoft Games | December 2012 | 2 | 1 |
| Nerve Software | 1999 | 3 | 1 |
| NetDevil | 1997 | 1 | — |
| Netflix | 2007 | — | 4 |
| NetherRealm Studios | 2010 | 12 | 1 |
| Neversoft | July 1994 | 18 | — |
| New World Computing | 1984 | 19 | 7 |
| New World Interactive | 2010 | 2 | 1 |
| Newgrounds | July 12, 1995 | 1 | 3 |
| NEXOFT Corporation | February 24, 1989 | — | 1 |
| Niantic Games Team | 2010 | 3 | 3 |
| Nicalis | 2007 | — | 5 |
| Nickelodeon | April 1979 | 1 | 2 |
| Nightdive Studios | 2013 | 4 | 7 |
| NinjaBee | 2004 | 1 | 1 |
| Nintendo of America | 1985 | — | 2 |
| Nintendo Software Technology | 1998 | 8 | — |
| NIS America | December 24, 2003 | — | 31 |
| Nostatic Software | — | 10 | 10 |
| Not a Sailor Studios | — | 1 | — |
| NStigate Games | March 1998 | 1 | — |
| NuFX | 1990 | 1 | — |
| Nvidia | April 5, 1993 | — | 1 |
| O3 Entertainment | 2004 | — | 1 |
| Oberon Media | 2003 | 2 | 3 |
| Obsidian Entertainment | June 12, 2003 | 10 | — |
| Oddworld Inhabitants | 1994 | 6 | 2 |
| Offbrand Games | June 7, 2024 | — | 1 |
| Oh, a Rock! Studios | March 24, 2014 | 4 | 4 |
| Ohio Distinctive Software | — | 3 | — |
| Oracle Corporation | June 16, 1977 | — | — |
| Origin Systems | 1983 | 21 | 10 |
| Orion Pictures | 1978 | — | 1 |
| Osgoode Media | 2016 | 1 | 1 |
| Other Ocean | 2006 | 7 | — |
| Outerloop Games | — | 1 | — |
| Outrage Games | 1997 | 1 | — |
| Page 44 Studios | 1998 | 1 | — |
| Pandemic Studios | 1998 | 7 | — |
| Pangea Software | 1987 | 3 | 2 |
| Panic | — | — | 5 |
| Panic Button | 2007 | 2 | — |
| Papaya Studio | 1999 | 4 | — |
| Paradigm Entertainment | March 1997 | 6 | — |
| Paragon Software | 1987 | — | 1 |
| Paramount Pictures | May 8, 1912 | — | 1 |
| Park Place Productions | 1989 | 3 | — |
| Parker Brothers | 1883 | 1 | 5 |