| Sickhead Games | October 2002 | 1 | — |
| Sierra On-Line | 1979 | — | 4 |
| Signal Studios | 2009 | 1 | — |
| Simon & Schuster | 1924 | 7 | 4 |
| Simutronics | 1987 | 3 | 1 |
| SingleTrac | 1995 | 3 | — |
| Sir-Tech | 1979 | 10 | 10 |
| Sirlin Games | 2005 | 1 | 1 |
| Ska Studios | 2001 | 2 | — |
| Skunkape Interactive | — | 1 | — |
| Skybound Entertainment | 1992 | 1 | — |
| Skybound Games | — | 1 | 6 |
| Skydance Media | 2006 | 1 | 1 |
| Sledgehammer Games | 2009 | 6 | 1 |
| Smash House Games | 2017 | 1 | 1 |
| Smoking Car Productions | 1993 | 1 | — |
| Smug Marmot Studios | — | 1 | 1 |
| Sniper Studios | 2006 | 1 | — |
| Snoozy Kazoo | May 2020 | 2 | — |
| Snowblind Studios | 1997 | 3 | — |
| Softdisk | 1981 | 3 | 5 |
| Software Creations | — | — | 1 |
| SomaSim | 2013 | 2 | — |
| Sonalysts (United States) | 1973 | 1 | 1 |
| Sony Computer Entertainment America | — | 1 | 6 |
| Sony Imagesoft | 1989 | — | — |
| Sony Interactive Entertainment | April 2016 | 31 | 349 |
| Sony Interactive Studios America | 1995 | 3 | — |
| Sony Pictures Digital | 1997 | — | 1 |
| SouthPeak Games | 1996 | — | 7 |
| Spark Unlimited | 2002 | 2 | — |
| Sparkypants Studios | 2011 | 1 | — |
| Spectrum HoloByte | 1983 | 2 | 5 |
| Spiderweb Software | 1994 | 19 | 19 |
| Sports Mogul | 1997 | — | — |
| Spry Fox | 2010 | 3 | 2 |
| Squiddershins | — | 2 | 1 |
| Stainless Steel Studios | 1997 | 2 | — |
| Stardock | 1991 | 14 | 12 |
| Starz Entertainment | April 28, 1997 | — | 2 |
| Steel Mantis | — | 1 | — |
| Stegosoft Games | November 14, 2013 | 1 | — |
| Stellar Stone | 2000 | 1 | — |
| Step Creative Group | 1994 | 1 | — |
| Stern Electronics | 1977 | 1 | 1 |
| Stone Lantern Games | — | 1 | — |
| Stormfront Studios | 1989 | 7 | — |
| Strange Scaffold | February 12, 2019 | 5 | 4 |
| Strategic Simulations | 1979 | 15 | 28 |
| Stray Bombay | — | 1 | 1 |
| Stray Kite Studios | — | 1 | — |
| Striking Distance Studios | 2019 | 1 | — |
| Studio Thunderhorse | — | 1 | — |
| Sublogic | 1977 | 4 | 3 |
| Summitsoft Entertainment | May 3, 1993 | — | 1 |
| Sun Microsystems | February 24, 1982 | — | — |
| Sunstorm Interactive | 1995 | 6 | — |
| Super Evil Megacorp | 2012 | 1 | 1 |
| Super X Studios | 1998 | 2 | 1 |
| Supergiant Games | 2009 | 1 | 1 |
| SuperVillain Studios | 2004 | 3 | 1 |
| Surreal Software | 1995 | 4 | — |
| Survios | 2013 | 5 | 4 |
| SwordSwipe Studios | — | 1 | — |
| Synapse Software | 1981 | 1 | — |
| Synergistic Software | 1978 | 2 | 1 |
| Take-Two Interactive | 1993 | 1 | 25 |
| Take-Two Licensing | 2004 | — | 2 |
| TalonSoft | 1995 | — | 1 |
| Tandy Corporation | 1919 | — | 1 |
| Tapulous | 2008 | 4 | — |
| Taxan | July 1981 | — | 2 |
| Team Meat | — | 1 | 1 |
| Team Salvato | 2017 | 1 | — |
| TeamKill Media | 2016 | 1 | 1 |
| Technical Education Research Centers | 1965 | 1 | — |
| Telegames | — | 1 | 3 |
| Telltale Games | July 2004 | 39 | 22 |
| Templar Studios | 1997 | 1 | — |
| Tender Claws | 2014 | 3 | 4 |
| Tengen | 1987 | 2 | 6 |
| Terminal Reality | 1994 | 8 | — |
| Terraglyph Interactive Studios | 1994 | 1 | — |
| Terrible Posture Games | — | 4 | 4 |
| Terrible Toybox | December 2, 2015 | — | 1 |
| The 3DO Company | September 12, 1991 | 8 | 25 |
| The Behemoth | 2003 | 3 | 2 |
| The Iconfactory | 1996 | 1 | — |
| The Initiative | — | 1 | — |
| The Label | 2016 | — | 2 |
| The Learning Company | 1980 | 7 | 6 |
| The MIX Games | May 24, 2021 | — | 1 |
| The Molasses Flood | November 5, 2014 | 1 | 1 |
| The New York Times | September 18, 1851 | 1 | — |
| The New York Times Company | September 18, 1851 | — | 1 |
| The Pokémon Company International | — | 1 | — |
| The Quantum Astrophysicists Guild | May 17, 2012 | 1 | 8 |
| The Sims Studio | 2006 | 4 | — |
| The Software Toolworks | 1980 | 2 | 2 |
| The Walt Disney Company | October 16, 1923 | — | 1 |