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34,989 games
- Soukoku no Kusabi: Hiiro no Kakera 3Released: April 15, 2010Developer: Design Factory
- 10 Gnomes in BolognaReleased: April 19, 2010Developer: Mateusz Skutnik
- All Star KarateReleased: April 20, 2010Developer: Blitz Games
- FluttabyesReleased: April 20, 2010Platforms: Microsoft Windows
- Lord of UltimaReleased: April 20, 2010Developer: EA Phenomic
- Slave Maker 3Released: April 20, 2010Series: Slave Maker
- 2025: Battle for FatherlandReleased: April 21, 2010Publisher: Akella
- NieRReleased: April 22, 2010Developer: Cavia
- NieR ReplicantReleased: April 22, 2010Developer: Cavia
- The Settlers IVReleased: April 22, 2010Developer: Ubisoft Blue Byte, Gameloft
- Tokyo Mono Hara Shi: Karasu no Mori Gakuen KitanReleased: April 22, 2010Platforms: PlayStation Portable
- 2010 FIFA World Cup South AfricaReleased: April 27, 2010Developer: EA Vancouver
- Alive 4-Ever ReturnsReleased: April 27, 2010Genre: shooter game
- NieR GestaltReleased: April 27, 2010Developer: Cavia
- Super Mario Bros. CrossoverReleased: April 27, 2010Engine: Adobe Flash
- Super Street Fighter IVReleased: April 27, 2010Developer: Dimps
- 10 Second RunReleased: April 28, 2010Developer: G-Mode
- Dragon Quest Monsters: Joker 2Released: April 28, 2010Developer: Tose Co.
- Kaeru Batake de TsukamaeteReleased: April 28, 2010Developer: Takuyo
- Serious Sam HD: The Second EncounterReleased: April 28, 2010Developer: Croteam
- Iron Man 2Released: April 29, 2010Developer: Sega Studios San Francisco
- Metal Gear Solid: Peace WalkerReleased: April 29, 2010Series: Metal Gear
- Tom Clancy's Splinter Cell: ConvictionReleased: April 29, 2010Series: Tom Clancy's Splinter Cell
- Ikinukissa: Kakushiaji ni Ai oReleased: April 30, 2010Platforms: Microsoft Windows
- Neko☆Koi! ~Nekogami-sama to Nekomimi no Tatari~Released: April 30, 2010Developer: Whirlpool
- PetapetaReleased: April 30, 2010Platforms: Microsoft Windows
- Give Up, RobotReleased: May 6, 2010Publisher: Adult Swim Games
- Ushinawareta Oto ToimuraReleased: May 7, 2010Platforms: browser game
- Lost Planet 2Released: May 11, 2010Developer: Capcom
- Skate 3Released: May 11, 2010Series: Skate
- Eschalon: Book IIReleased: May 12, 2010Developer: Basilisk Games
- Flight of the IcarusReleased: May 12, 2010Developer: Muse Games
- Rocket KnightReleased: May 12, 2010Publisher: Konami
- Bit.Trip RunnerReleased: May 17, 2010Developer: Choice Provisions
- Art StoriesReleased: May 18, 2010Developer: IBA Group
- Prince of Persia: The Forgotten SandsReleased: May 18, 2010Developer: Ubisoft Quebec
- Prince of Persia: The Forgotten SandsReleased: May 18, 2010Engine: Ubisoft Anvil
- Shrek Forever AfterReleased: May 18, 2010Developer: XPEC Entertainment
- Trauma TeamReleased: May 18, 2010Series: Trauma Center
- Captain Tsubasa: New Kick OffReleased: May 20, 2010Developer: Konami
- WarioWare: D.I.Y. ShowcaseReleased: May 20, 2010Developer: Intelligent Systems, Nintendo Software Planning & Development
- Super Mario Galaxy 2Released: May 23, 2010Developer: Nintendo Entertainment Analysis & Development
- Protect Me KnightReleased: May 24, 2010Developer: Ancient
- Backyard Sports: Sandlot SluggersReleased: May 25, 2010Developer: HB Studios, Powerhead Games
- Golden Gash BellReleased: May 25, 2010Platforms: mobile phone
- Command Ops: Battles from the BulgeReleased: May 26, 2010Developer: Panther Games
- Blaze Union: Story to Reach the FutureReleased: May 27, 2010Developer: Sting
- Desert KingdomReleased: May 27, 2010Developer: Otomate
- Okiba ga Nai!Released: May 27, 2010Platforms: Microsoft Windows
- EvolimitReleased: May 28, 2010Genre: chuunige, visual novel
- No More Heroes 2: Desperate StruggleReleased: May 28, 2010Developer: Grasshopper Manufacture
- Taiko no Tatsujin PlusReleased: May 28, 2010Developer: Namco
- X-ScapeReleased: May 31, 2010Developer: Q-Games
- The Sims 3: AmbitionsReleased: June 1, 2010Developer: Electronic Arts
- Defense Grid: Resurgence Map Pack 1Released: June 2, 2010Developer: Hidden Path Entertainment
- Doctor Who: City of the DaleksReleased: June 2, 2010Series: Doctor Who: The Adventure Games
- JiseiReleased: June 4, 2010Developer: SakeVisual
- International Cricket Captain 2010Released: June 5, 2010Series: International Cricket Captain
- Transportando o BrasilReleased: June 5, 2010Developer: Dynamic Games
- @CameliaGirls: Cewek Cewek CameliaReleased: June 6, 2010Engine: Ren'Py
- Zoo Disc GolfReleased: June 7, 2010Developer: Sonalysts (United States)
- Green Day: Rock BandReleased: June 8, 2010Developer: Harmonix Music Systems
- Defense Grid: Resurgence Map Pack 2Released: June 9, 2010Developer: Hidden Path Entertainment
- Earthworm Jim HDReleased: June 9, 2010Developer: Gameloft
- Xenoblade ChroniclesReleased: June 10, 2010Developer: Monolith Soft Inc.
- Mega Man Network TransmissionReleased: June 11, 2010Developer: Arika
- Real Warfare 1242Released: June 11, 2010Platforms: Microsoft Windows
- Making History II: The War of the WorldReleased: June 15, 2010Developer: Muzzy Lane
- Defense Grid: Resurgence Map Pack 3Released: June 16, 2010Developer: Hidden Path Entertainment
- Big Beach Sports 2Released: June 18, 2010Developer: Jet Black Games
- Face Pilot: Fly With Your Nintendo DSi Camera!Released: June 18, 2010Developer: HAL Laboratory
- GreenTech+ Legacy EditionReleased: June 21, 2010Developer: Vertigo Gaming
- Puzzle DimensionReleased: June 21, 2010Platforms: Microsoft Windows, macOS
- The Tales of Bearsworth Manor: Puzzling PagesReleased: June 21, 2010Developer: Square Enix
- Puzzle Quest 2Released: June 22, 2010Developer: Infinity Plus Two
- Secret Files: TunguskaReleased: June 22, 2010Developer: Animation Arts
- Defense Grid: Resurgence Map Pack 4Released: June 23, 2010Developer: Hidden Path Entertainment
- The Ren'ai Simulation 2: FureaiReleased: June 23, 2010
- Atelier Totori: The Adventurer of ArlandReleased: June 24, 2010Developer: Gust Co. Ltd.
- Hatsune Miku: Project DIVA Dreamy TheaterReleased: June 24, 2010Series: Hatsune Miku: Project DIVA
- Moujuutsukai to Ouji-samaReleased: June 24, 2010Developer: Otomate, Design Factory
- Sherlock Holmes and the Mystery of Osborne HouseReleased: June 24, 2010Developer: Frogwares
- Tokimeki Memorial Girl's Side: 3rd StoryReleased: June 24, 2010Developer: Konami
- Bitter SmileReleased: June 25, 2010Platforms: Microsoft Windows, PlayStation Vita
- En-Eins PerfekteweltReleased: June 25, 2010Platforms: arcade video game machine
- Schoolmate 2Released: June 25, 2010Developer: Illusion
- Shirogane no Cal to Soukuu no JoouReleased: June 25, 2010Developer: Kogado Studio
- SingularityReleased: June 25, 2010Developer: Raven Software
- The Tales of Bearsworth Manor: Chaotic ConflictsReleased: June 25, 2010Developer: Square Enix
- Jett RocketReleased: June 28, 2010Developer: Shin'en Multimedia
- ARMA 2: Operation ArrowheadReleased: June 29, 2010Developer: Bohemia Interactive
- Lego Harry Potter: Years 1–4Released: June 29, 2010Developer: Traveller's Tales
- Nancy Drew: Trail of the TwisterReleased: June 29, 2010Developer: Her Interactive
- Sniper: Ghost WarriorReleased: June 29, 2010Developer: CI Games S.A.
- Scared Rider XechsReleased: July 2010Developer: Rejet
- Digimon Story Lost EvolutionReleased: July 1, 2010Developer: Bandai Namco Entertainment
- Inazuma Eleven 3Released: July 1, 2010Developer: Level-5
- Taiko no Tatsujin DS: Dororon! Yokai Daikessen!!Released: July 1, 2010Developer: Namco
- Tiger Woods PGA Tour 11Released: July 2, 2010Developer: EA Orlando
- Harry Potter and the Half-Blood PrinceReleased: July 3, 2010Developer: Electronic Arts