- Secret Agent HDReleased: June 30, 2021Developer: Emberheart Games, Apogee Software
- Doki Doki Literature Club Plus!Released: July 2021Developer: Team Salvato
- Billionaire LoversReleased: July 2, 2021Platforms: Microsoft Windows, macOS, Linux
- Matrix Brain TwisterReleased: July 2, 2021Platforms: Microsoft Windows, macOS, Linux
- Dash LambReleased: July 6, 2021Platforms: Microsoft Windows, macOS, Linux
- Crash Drive 3Released: July 8, 2021Platforms: Microsoft Windows, macOS, Linux
- SHAKESPEARE? More like THIRSTspeare, amirite?Released: July 8, 2021Developer: Stegalosaurus Game Development
- Color BreakersReleased: July 9, 2021Platforms: Microsoft Windows, macOS, Linux
- FunctionalReleased: July 9, 2021Platforms: Microsoft Windows, macOS, Linux
- HomeboundReleased: July 9, 2021Platforms: Microsoft Windows, Linux
- Cabin FeverReleased: July 12, 2021Developer: Sad Panda Studios
- BridgeFix 2=3-1Released: July 15, 2021Platforms: Microsoft Windows, Linux
- Pugmire: Treasure of the Sea DogsReleased: July 15, 2021Developer: Choice of Games
- Raptor BoyfriendReleased: July 15, 2021Developer: Eastasiasoft, Rocket Adrift, Ratalaika Games
- Abandoned Croxon MansionReleased: July 16, 2021Developer: Anamik Majumdar
- Negligee: Opposites AttractReleased: July 16, 2021Platforms: Microsoft Windows, macOS, Linux
- Mythos Ever After: A Cthulhu Dating Sim RXReleased: July 20, 2021Developer: Stegalosaurus Game Development
- Angle SoccerReleased: July 21, 2021Platforms: Microsoft Windows, Linux
- Song of FarcaReleased: July 21, 2021Platforms: Microsoft Windows, macOS, Linux
- Deepest ChamberReleased: July 22, 2021Publisher: Those Awesome Guys
- Crypto Is DeadReleased: July 23, 2021Developer: The Moon Pirates
- EggsolotlReleased: July 25, 2021Developer: Axol Studio, LLC
- Idol ManagerReleased: July 26, 2021Developer: Glitch Pitch
- Sakura Forest Girls 2Released: July 26, 2021Developer: Winged Cloud
- Car LooperReleased: July 27, 2021Platforms: Microsoft Windows, macOS, Linux
- Ayo the ClownReleased: July 28, 2021Developer: Eastasiasoft, Cloud M1
- The KeeperReleased: July 28, 2021Platforms: Microsoft Windows, macOS, Linux
- Unbound: Worlds ApartReleased: July 28, 2021Developer: Alien Pixel Studios, Nephilim Game Studios
- LuminyteReleased: July 29, 2021Platforms: Microsoft Windows, macOS, Linux
- Misericorde: Volume OneReleased: July 29, 2021Platforms: Microsoft Windows, Linux
- Murder on the Marine ExpressReleased: July 30, 2021Developer: 1564 Studio
- No Longer HomeReleased: July 30, 2021Developer: Humble Grove
- VomitoreumReleased: July 30, 2021Developer: Scumhead
- The VaultsReleased: August 2, 2021Platforms: Microsoft Windows, Linux
- Svoboda 1945Released: August 3, 2021Platforms: Microsoft Windows, macOS, Linux
- Rick HendersonReleased: August 4, 2021Publisher: Eastasiasoft
- Toodee and TopdeeReleased: August 4, 2021Engine: GameMaker
- Aspiring LightReleased: August 5, 2021Platforms: Microsoft Windows, macOS, Linux
- Death TrashReleased: August 5, 2021Developer: Crafting Legends
- Haven ParkReleased: August 5, 2021Developer: Bubblebird Studio
- Almost My FloorReleased: August 6, 2021Publisher: Sometimes You
- Hunter GirlsReleased: August 6, 2021Platforms: Microsoft Windows, macOS, Linux
- ObscuraReleased: August 6, 2021Platforms: Microsoft Windows, macOS, Linux
- Axiom Verge 2Released: August 11, 2021Developer: Thomas Happ Games
- Cat’s Princess - visual novel / OtomeReleased: August 11, 2021Platforms: Microsoft Windows, macOS, Linux
- Battlemage: Magic by MailReleased: August 12, 2021Developer: Choice of Games
- Non - The First WarpReleased: August 12, 2021Platforms: Microsoft Windows, macOS, Linux
- Clean SlateReleased: August 13, 2021Platforms: Microsoft Windows, Linux
- Furry Shakespeare: Dreamin' of One Lazy Dead MidsummerReleased: August 13, 2021Developer: Stegalosaurus Game Development
- Space to GrowReleased: August 13, 2021Developer: Metasepia Games
- WaveTilesReleased: August 13, 2021Platforms: Microsoft Windows, macOS, Linux
- Life is HardReleased: August 14, 2021Platforms: Microsoft Windows, macOS, Linux
- Last VillageReleased: August 16, 2021Platforms: Microsoft Windows, Linux
- Conquest of Elysium 5Released: August 17, 2021Developer: Illwinter Game Design
- JoyspringReleased: August 17, 2021Engine: Godot
- BlackberryNOVAReleased: August 19, 2021Platforms: Microsoft Windows, Linux
- Blood for PoppiesReleased: August 19, 2021Developer: Hosted Games
- FishyReleased: August 20, 2021Platforms: Microsoft Windows, macOS, Linux
- Incel SyndromeReleased: August 20, 2021Platforms: Microsoft Windows, macOS, Linux
- Markus Ritter - The Lost FamilyReleased: August 20, 2021Platforms: Microsoft Windows, Linux
- Wrestledunk SportsReleased: August 20, 2021Developer: Team Fractal Alligator
- Embraced by AutumnReleased: August 24, 2021Developer: ebi-hime
- Porter in the CastleReleased: August 24, 2021Platforms: Microsoft Windows, macOS, Linux
- Psychonauts 2Released: August 25, 2021Developer: Double Fine
- Ultimate ADOM - Caverns of ChaosReleased: August 25, 2021Developer: Team ADOM
- Axis Football 2021Released: August 26, 2021Platforms: Microsoft Windows, macOS, Linux
- Black Geyser: Couriers of DarknessReleased: August 26, 2021Platforms: Microsoft Windows, macOS, Linux
- The Play's the ThingReleased: August 26, 2021Developer: Choice of Games
- Am MadnessReleased: August 27, 2021Platforms: Microsoft Windows, Linux
- LamentumReleased: August 27, 2021Publisher: Neon Doctrine
- Ragtag RacingReleased: August 27, 2021Platforms: Microsoft Windows, Linux
- Horny SekaiReleased: August 29, 2021Platforms: Microsoft Windows, macOS, Linux
- Light Fairytale Episode 2Released: August 30, 2021Developer: Neko.works
- Mix Hentai GirlsReleased: August 30, 2021Platforms: Microsoft Windows, macOS, Linux
- PuzzledorfReleased: August 30, 2021Platforms: Microsoft Windows, Linux
- TinytopiaReleased: August 30, 2021Publisher: Mastiff
- Beyond Mankind: The AwakeningReleased: August 31, 2021Platforms: Microsoft Windows, Linux
- Tap NinjaReleased: September 2021Platforms: Microsoft Windows, macOS, Linux, Android
- Furry Shakespeare: Oops! All Dragons!Released: September 2, 2021Developer: Stegalosaurus Game Development
- Making it HomeReleased: September 3, 2021Platforms: Microsoft Windows, Linux
- Robot DaycareReleased: September 3, 2021Platforms: Microsoft Windows, macOS, Linux
- Swallow the SeaReleased: September 3, 2021Platforms: Microsoft Windows, Linux
- Heads Will RollReleased: September 4, 2021Platforms: Microsoft Windows, Linux
- 69 Yuki LoveReleased: September 6, 2021Platforms: Microsoft Windows, Linux
- Anti-Science BrigadeReleased: September 6, 2021Platforms: Microsoft Windows, macOS, Linux
- Temple with trapsReleased: September 6, 2021Platforms: Microsoft Windows, macOS, Linux
- The Looking StoneReleased: September 6, 2021Platforms: Microsoft Windows, Linux
- Big Klondike - Classic SolitaireReleased: September 8, 2021Publisher: Subsoap
- HotGirls Sliding PuzzleReleased: September 8, 2021Platforms: Microsoft Windows, Linux
- Jester / KingReleased: September 8, 2021Platforms: Microsoft Windows, macOS, Linux
- ResidualReleased: September 9, 2021Developer: Orange Pixel
- Rift's CaveReleased: September 9, 2021Developer: Volens Nolens Games
- The Vampire RegentReleased: September 9, 2021Developer: Hosted Games
- Tux and FannyReleased: September 9, 2021Platforms: Microsoft Windows, macOS, Linux, Xbox Series X and Series S
- Balloon AzunaReleased: September 10, 2021Developer: Anamik Majumdar
- Fantasy Jigsaw Puzzle 4Released: September 10, 2021Platforms: Microsoft Windows, macOS, Linux
- Mondealy: Day OneReleased: September 13, 2021Platforms: Microsoft Windows, Linux
- TechBeat HeartReleased: September 13, 2021Platforms: Microsoft Windows, Linux
- Kick ItReleased: September 14, 2021Platforms: Microsoft Windows, macOS, Linux
- Grim wanderings 2Released: September 15, 2021Platforms: Microsoft Windows, Linux