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- PalmRideReleased: September 16, 2021Platforms: Microsoft Windows, Linux
- Wraiths of SENTINELReleased: September 16, 2021Developer: Choice of Games
- Tails of IronReleased: September 17, 2021Publisher: United Label
- 69 Erika LoveReleased: September 18, 2021Platforms: Microsoft Windows, Linux
- D-CorpReleased: September 20, 2021Developer: Frogsong Studios
- Skattered DreamReleased: September 20, 2021Platforms: Microsoft Windows, Linux
- AlmazyReleased: September 21, 2021Platforms: Microsoft Windows, macOS, Linux
- If On A Winter's Night, Four TravelersReleased: September 21, 2021Engine: Adventure Game Studio
- Welcome to Free Will - Episode 1Released: September 22, 2021Platforms: Microsoft Windows, Linux
- Find Match IconsReleased: September 23, 2021Platforms: Microsoft Windows, macOS, Linux
- Hack or Die!Released: September 23, 2021Platforms: Microsoft Windows, macOS, Linux
- Hidden FlowersReleased: September 23, 2021Platforms: Microsoft Windows, macOS, Linux
- Love SeasonReleased: September 24, 2021Platforms: Microsoft Windows, macOS, Linux
- Ninja: Rise of a HeroReleased: September 24, 2021Platforms: Microsoft Windows, Linux
- PawnbarianReleased: September 24, 2021Platforms: Microsoft Windows, macOS, Linux
- Super Auto PetsReleased: September 24, 2021Platforms: Microsoft Windows, Linux, web browser, Android
- The Book of BondmaidsReleased: September 24, 2021Platforms: Microsoft Windows, macOS, Linux
- Would you like to run an idol café? 2Released: September 27, 2021Developer: StarlightTree Games
- Steel AssaultReleased: September 28, 2021Publisher: Tribute Games
- 69 Hitomi LoveReleased: September 29, 2021Platforms: Microsoft Windows, Linux
- Centipede: RechargedReleased: September 29, 2021Platforms: Microsoft Windows, Linux
- Operation ThunderReleased: September 29, 2021Platforms: Microsoft Windows, Linux
- Aeon DriveReleased: September 30, 2021Developer: 2Awesome Studio
- Bonfire PeaksReleased: September 30, 2021Platforms: Microsoft Windows, macOS, Linux
- Gutting Goblins!Released: September 30, 2021Platforms: Microsoft Windows, Linux
- Hobo Cat AdventuresReleased: September 30, 2021Platforms: Microsoft Windows, Linux
- Impostor FactoryReleased: September 30, 2021Developer: Freebird Games
- Space RevengeReleased: September 30, 2021Publisher: JanduSoft
- The Hero of BangaonaReleased: October 2021Developer: Anamik Majumdar
- Turing CompleteReleased: October 2, 2021Platforms: Microsoft Windows, macOS, Linux
- Closed HandsReleased: October 4, 2021Platforms: Microsoft Windows, macOS, Linux
- Load Roll DieReleased: October 6, 2021Platforms: Microsoft Windows, macOS, Linux
- Tower To HeavenReleased: October 6, 2021Platforms: Microsoft Windows, Linux
- Cooking CompanionsReleased: October 7, 2021Platforms: Microsoft Windows, Linux, Xbox Series X and Series S
- Gra&VityReleased: October 7, 2021Platforms: Microsoft Windows, Linux
- Interstellar AirgapReleased: October 7, 2021Developer: Hosted Games
- The LightbringerReleased: October 7, 2021Platforms: Microsoft Windows, Linux
- Tails & Titties Hot SpringReleased: October 11, 2021Platforms: Microsoft Windows, macOS, Linux
- CeillessReleased: October 12, 2021Platforms: Microsoft Windows, macOS, Linux
- IncrelutionReleased: October 13, 2021Platforms: Microsoft Windows, macOS, Linux
- Midnight ProtocolReleased: October 13, 2021Developer: LuGus Studios
- Bounty BelowReleased: October 14, 2021Platforms: Microsoft Windows, macOS, Linux
- Henchman StoryReleased: October 14, 2021Publisher: Top Hat Studios
- The Jackbox Party Pack 8Released: October 14, 2021Developer: Jackbox Games
- Dark CryptReleased: October 15, 2021Engine: Godot
- Love Duction! The Guide for Galactic LoversReleased: October 15, 2021Publisher: Sekai Project
- Pathological TiresReleased: October 15, 2021Platforms: Microsoft Windows, macOS, Linux
- Hidden TownReleased: October 16, 2021Platforms: Microsoft Windows, macOS, Linux
- Hidden WaterReleased: October 16, 2021Platforms: Microsoft Windows, macOS, Linux
- Trouble Hunter Chronicles: The Stolen CreedReleased: October 16, 2021Engine: Ren'Py
- King BooReleased: October 18, 2021Platforms: Microsoft Windows, Linux
- Dual Souls: The Last BearerReleased: October 19, 2021Platforms: Microsoft Windows, macOS, Linux
- Escape SimulatorReleased: October 19, 2021Developer: Pine Studio
- InscryptionReleased: October 19, 2021Publisher: Devolver Digital
- Behind Closed Doors: A Developer's TaleReleased: October 20, 2021Publisher: Sometimes You
- Dreams of Desire: Definitive EditionReleased: October 20, 2021Platforms: Microsoft Windows, Linux
- Drox Operative 2Released: October 20, 2021Platforms: Microsoft Windows, Linux
- EvertriedReleased: October 20, 2021Developer: Lunic Games
- JARSReleased: October 20, 2021Publisher: Daedalic Entertainment
- Rubicon: a conspiracy of silenceReleased: October 20, 2021Platforms: Microsoft Windows, macOS, Linux
- Demon Hunter 4: Riddles of LightReleased: October 21, 2021Developer: Brave Giant
- Furries & Scalies: Super Scary Halloween Spooky Times Part IIReleased: October 21, 2021Developer: Stegalosaurus Game Development
- Luffy: Way Back HomeReleased: October 21, 2021Platforms: Microsoft Windows, macOS, Linux
- Tandem: A Tale of ShadowsReleased: October 21, 2021Developer: Monochrome Paris
- Toilet Flushing SimulatorReleased: October 21, 2021Platforms: Microsoft Windows, macOS, Linux
- AlisaReleased: October 22, 2021Platforms: Microsoft Windows, macOS, Linux, Xbox Series X and Series S
- Amazing Superhero SquadReleased: October 22, 2021Developer: Siberian Koala
- Juro JanosikReleased: October 25, 2021Platforms: Microsoft Windows, macOS, Linux
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- Rising ConstellationReleased: October 27, 2021Platforms: Microsoft Windows, macOS, Linux
- Black Widow: RechargedReleased: October 28, 2021Developer: AdamVision Studios, SneakyBox
- FukTopia 3Released: October 28, 2021Platforms: Microsoft Windows, Linux
- Milli & GregReleased: October 28, 2021Developer: 2ndBoss
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- Crab GameReleased: October 29, 2021Platforms: Microsoft Windows, macOS, Linux
- Hypnagogia: Boundless DreamsReleased: October 29, 2021Platforms: Microsoft Windows, macOS, Linux
- Summoner's MessReleased: October 29, 2021Platforms: Microsoft Windows, Linux
- Super Dream DasherReleased: October 29, 2021Platforms: Microsoft Windows, Linux
- UnpackingReleased: November 2, 2021Developer: Witch Beam
- FishardsReleased: November 3, 2021Platforms: Microsoft Windows, macOS, Linux
- Miasma: Citizens of Free ThoughtReleased: November 3, 2021Platforms: Microsoft Windows, macOS, Linux
- Schildmaid MXReleased: November 4, 2021Developer: HitP Studio
- 69 Mary LoveReleased: November 5, 2021Platforms: Microsoft Windows, Linux
- 8089: The Next Action RPGReleased: November 5, 2021Developer: Phr00t's Software
- Deep Space Battle SimulatorReleased: November 5, 2021Platforms: Microsoft Windows, Linux
- Clunky HeroReleased: November 9, 2021Developer: Chaosmonger Studio
- Alchemic CutieReleased: November 11, 2021Platforms: Microsoft Windows, macOS, Linux
- BobokReleased: November 11, 2021Platforms: Microsoft Windows, macOS, Linux
- SmintheusReleased: November 11, 2021Platforms: Microsoft Windows, Linux
- Raiders of the Icepeak MountainsReleased: November 12, 2021Developer: Hosted Games
- Run, Kitty! - A Furry Gay Visual NovelReleased: November 12, 2021Platforms: Microsoft Windows, macOS, Linux
- Temple of Endless NightReleased: November 12, 2021Developer: Hosted Games
- Sakura Forest Girls 3Released: November 15, 2021Developer: Winged Cloud
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- Rob RichesReleased: November 16, 2021Platforms: Microsoft Windows, Linux
- Tavern MasterReleased: November 16, 2021Platforms: Microsoft Windows, macOS, Linux
- 69 Moriko LoveReleased: November 17, 2021Platforms: Microsoft Windows, Linux
- Arcadia FallenReleased: November 17, 2021Developer: Galdra Studios
- Hero of the Kingdom: The Lost Tales 2Released: November 19, 2021Developer: Lonely Troops