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34,989 games
- Crayon Shin-Chan: Densetsu o Yobu - Omake no Miyako Shokkugān!Released: March 23, 2006Developer: Inti Creates
- Dynasty Warriors Vol. 2Released: March 23, 2006Developer: Koei Tecmo Holdings
- Memories Off: And Then AgainReleased: March 23, 2006Platforms: Microsoft Windows
- Yggdra UnionReleased: March 23, 2006Developer: Sting
- Lost ChildReleased: March 24, 2006Platforms: Microsoft Windows
- Rikorisu ~Lycoris Radiata~Released: March 24, 2006Developer: Terios
- SetsueiReleased: March 24, 2006Publisher: Silver Bullet
- Let's Make a Soccer Team!Released: March 29, 2006Developer: Sega Sports R&D
- Stoked Rider Big Mountain SnowboardingReleased: March 29, 2006Developer: Bongfish
- Top Spin 2Released: March 29, 2006Developer: Indie Built
- Alexey's DwiceReleased: March 30, 2006Publisher: EGames
- Battlefield 2: Modern CombatReleased: March 30, 2006Developer: DICE
- Gunparade Orchestra: Midori no ShōReleased: March 30, 2006Developer: Alfa System
- Kashimashi: Girl Meets Girl Hajimete no Natsu MonogatariReleased: March 30, 2006Developer: Vridge
- Animal Crossing: Wild WorldReleased: March 31, 2006Developer: Nintendo Entertainment Analysis & Development
- Elf All Stars Datsui Jan 3Released: March 31, 2006Platforms: Microsoft Windows
- Snowy: Lunch RushReleased: March 31, 2006Developer: Aliasworlds Entertainment
- Air ConflictsReleased: April 2006Developer: 3Division Entertainment
- Earth 2160Released: April 1, 2006Developer: Reality Pump Studios
- Mystery Case Files: Prime SuspectsReleased: April 6, 2006Developer: Big Fish Games
- Tenchu: Dark SecretReleased: April 6, 2006Developer: Polygon Magic
- Gods: Lands of InfinityReleased: April 7, 2006Developer: Cypronia
- Tomb Raider: LegendReleased: April 7, 2006Developer: Crystal Dynamics
- Densetsu no Stafy 4Released: April 13, 2006Developer: Tose Co.
- Kōenji Joshi SoccerReleased: April 13, 2006Platforms: Nintendo DSi
- City LifeReleased: April 14, 2006Developer: Monte Cristo
- Barrow HillReleased: April 16, 2006Developer: Shadow Tor Studios
- Dreamfall: The Longest JourneyReleased: April 17, 2006Developer: Funcom
- Take Command: 2nd ManassasReleased: April 18, 2006Developer: MadMinute Games
- Dragon Quest: Shōnen Yangus to Fushigi no DungeonReleased: April 20, 2006Developer: Cavia
- Mother 3Released: April 20, 2006Developer: HAL Laboratory
- SpellForce 2: Shadow WarsReleased: April 20, 2006Developer: EA Phenomic
- StarShift: The Zaran LegacyReleased: April 20, 2006Platforms: Microsoft Windows
- ŌkamiReleased: April 20, 2006Developer: Clover Studio
- Aozora no Mieru OkaReleased: April 21, 2006Platforms: Microsoft Windows
- Honoo no Haramase Jinsei: Ano Koro ni Modotte Haramase NightReleased: April 21, 2006Developer: SQUEEZ
- RapeLayReleased: April 21, 2006Developer: Illusion
- Yokubari SabotenReleased: April 21, 2006Developer: AliceSoft
- 2006 FIFA World CupReleased: April 24, 2006Developer: EA Vancouver
- Black & White 2: Battle of the GodsReleased: April 24, 2006Developer: Lionhead Studios
- Guilty Gear Dust StrikersReleased: April 25, 2006Developer: Arc System Works
- KOF: Maximum Impact 2Released: April 27, 2006Developer: SNK
- Petz: Dogz 2Released: April 27, 2006Developer: MTO
- Desperados 2: Cooper's RevengeReleased: April 28, 2006Developer: Spellbound Entertainment
- Fukō na KamiReleased: April 28, 2006Platforms: Microsoft Windows
- Guild Wars FactionsReleased: April 28, 2006Developer: ArenaNet
- Princess WaltzReleased: April 28, 2006Developer: Pulltop
- Sabae no ŌReleased: April 28, 2006Platforms: Microsoft Windows
- Star Wolves 2Released: April 28, 2006Developer: X-bow Software
- Strategic Command Classic: WWIIReleased: April 28, 2006Developer: Fury Software
- TriptychReleased: April 28, 2006Developer: ALcot
- Wiz AnniversaryReleased: April 28, 2006Developer: Favorite
- Neverwinter Nights: Infinite DungeonsReleased: May 2006Series: Neverwinter Nights
- Zoo Tycoon 2: African AdventureReleased: May 2006Developer: Blue Fang Games
- Shadowgrounds DemoReleased: May 1, 2006Developer: Frozenbyte
- Holiday ExpressReleased: May 4, 2006Developer: HipSoft
- Ape Escape: On the LooseReleased: May 5, 2006Series: Ape Escape
- Prince VladimirReleased: May 5, 2006Developer: Pipe studio
- Totally Spies!: Zombie Jamboree!Released: May 10, 2006Publisher: Brighter Minds
- Eureka Seven Vol. 2: The New VisionReleased: May 11, 2006Developer: Bandai
- New Super Mario Bros.Released: May 15, 2006Developer: Nintendo
- Heroes of Might and Magic VReleased: May 16, 2006Developer: Nival
- Kim Possible: Legend of the Monkey’s EyeReleased: May 16, 2006Platforms: Microsoft Windows, macOS
- Beatmania IIDX 11 IIDXREDReleased: May 18, 2006Developer: Konami
- JuicedReleased: May 18, 2006Developer: THQ Digital Studios UK
- The Sims 2 MobileReleased: May 22, 2006Publisher: Electronic Arts
- Devil May Cry 3: Special EditionReleased: May 23, 2006Platforms: Microsoft Windows
- Metroid Prime HuntersReleased: May 23, 2006Developer: Nintendo Software Technology
- Rogue TrooperReleased: May 23, 2006Developer: Rebellion Developments
- Dragon Quest & Final Fantasy in Itadaki Street PortableReleased: May 25, 2006Developer: Think Garage
- HidamariReleased: May 26, 2006Developer: AXL
- Kishin Hishō DemonbaneReleased: May 26, 2006Developer: Nitroplus
- Masquerade: Hell AcademyReleased: May 26, 2006Publisher: JAST USA
- PSI: Syberian ConflictReleased: May 26, 2006Publisher: Strategy First, Akella
- Hitman: Blood MoneyReleased: May 30, 2006Developer: Feral Interactive
- Half-Life 2: Episode OneReleased: June 2006Developer: Valve Corporation
- WingNuts 2Released: June 2006Developer: Freeverse
- The Movies: Stunts & EffectsReleased: June 6, 2006Developer: Lionhead Studios
- MotoGP '06Released: June 9, 2006Developer: Black Rock Studio
- Star Defender 3Released: June 9, 2006Genre: arcade
- Digimon World DSReleased: June 15, 2006Developer: Bandai Namco Holdings
- Doko Demo Issyo: Let's Gakkou!Released: June 15, 2006Series: Doko Demo Issyo
- Metal Saga: Season of SteelReleased: June 15, 2006Developer: Crea-Tech
- DarkStar OneReleased: June 16, 2006Developer: Ascaron
- Hard Truck ApocalypseReleased: June 19, 2006Developer: Targem Games
- Rome: Total War: AlexanderReleased: June 19, 2006Developer: Creative Assembly, Feral Interactive
- MotoGP 4Released: June 20, 2006Developer: Namco
- NFL Head CoachReleased: June 20, 2006Developer: Electronic Arts
- Valkyrie Profile 2: SilmeriaReleased: June 22, 2006Developer: Tri-Ace
- "Nakadashi" Igai wa Kōsoku Ihan!! Joshikōsai Nottori KeikakuReleased: June 23, 2006Developer: MBS TRUTH
- AmanatsuReleased: June 23, 2006Developer: chuable
- Kanojo-tachi no RyūgiReleased: June 23, 2006Platforms: Microsoft Windows
- Kimi to Koi Shite MusubareteReleased: June 23, 2006Developer: RusK
- LocoRocoReleased: June 23, 2006Developer: Japan Studio
- Titan QuestReleased: June 26, 2006Developer: Iron Lore Entertainment
- Trilby's NotesReleased: June 26, 2006Platforms: Microsoft Windows
- Crusty DemonsReleased: June 27, 2006Publisher: Deep Silver
- Half-Life 2: SurvivorReleased: June 28, 2006Developer: Taito, Valve Corporation
- Juiced: EliminatorReleased: June 28, 2006Developer: THQ Digital Studios UK
- Atelier Iris 3: Grand PhantasmReleased: June 29, 2006Developer: Gust Co. Ltd.