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- Bloons TDReleased: August 16, 2007Developer: Ninja Kiwi
- GeoDefenseReleased: 2008Developer: David Whatley
- GeoDefense SwarmReleased: 2008Genre: tower defense
- Defense Grid: The AwakeningReleased: December 8, 2008Developer: Hidden Path Entertainment
- The Creeps!Released: December 23, 2008Platforms: Android
- Final Fantasy Crystal Chronicles: My Life as a DarklordReleased: June 30, 2009Developer: Square Enix
- Robo DefenseReleased: September 16, 2009Platforms: Android
- South Park Let's Go Tower Defense Play!Released: October 7, 2009Developer: Doublesix
- The Tales of Bearsworth Manor: Chaotic ConflictsReleased: June 25, 2010Developer: Square Enix
- Paper Wars: Cannon FodderReleased: September 2010Developer: Draw Distance
- Two Worlds II Castle DefenseReleased: June 14, 2011Developer: Reality Pump Studios
- Orcs Must Die!Released: October 5, 2011Developer: Robot Entertainment
- Dungeon DefendersReleased: October 18, 2011Developer: Chromatic Games
- Bloons TD BattlesReleased: 2012Developer: Ninja Kiwi
- Defenders of the Mystic GardenReleased: April 10, 2012Developer: Twisted Dragon Media
- Go Home Dinosaurs!Released: March 14, 2013Developer: Fire Hose Games
- Prime World: DefendersReleased: June 2013Developer: Nival
- 300 DwarvesReleased: June 17, 2013Developer: Artifex Mundi
- Kingdom Rush FrontiersReleased: September 26, 2013Developer: Ironhide Game Studio
- Metal Slug DefenseReleased: 2014Developer: SNK
- Kingdom RushReleased: January 6, 2014Developer: Ironhide Game Studio
- Plants vs. Zombies: Garden WarfareReleased: February 28, 2014Developer: Electronic Arts
- SentinelReleased: April 22, 2014Developer: Matthew Brown
- Age of Empires: Castle SiegeReleased: September 17, 2014Developer: Smoking Gun Interactive, Xbox Game Studios
- Defense Grid 2Released: September 23, 2014Developer: Hidden Path Entertainment
- Royal DefenseReleased: November 6, 2014Publisher: 8floor
- Bloons TD 5Released: November 19, 2014Developer: Ninja Kiwi
- Dungeon Defenders IIReleased: December 5, 2014Developer: Chromatic Games
- ParticulaReleased: February 2, 2015Developer: Microblast Games
- Reigning CatsReleased: August 28, 2015Engine: GameMaker
- Gnumz: Masters of DefenseReleased: December 21, 2015Developer: Creobit
- Prime World: Defenders 2Released: January 6, 2016Developer: Nival
- Star Fox GuardReleased: April 22, 2016Developer: Nintendo Entertainment Planning & Development
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- Gotta ProtectorsReleased: July 28, 2016Developer: Ancient
- No Heroes HereReleased: October 3, 2017Platforms: Microsoft Windows, macOS
- Legion TD 2Released: November 20, 2017Platforms: Microsoft Windows
- Magic Siege - DefenderReleased: November 30, 2017Platforms: Microsoft Windows, macOS
- Greece Defense TDReleased: February 18, 2018Platforms: Microsoft Windows, macOS
- Warstone TDReleased: May 23, 2018Developer: Battlecruiser Games
- Kingdom Rush VengeanceReleased: November 22, 2018Developer: Ironhide Game Studio
- Audio InfectionReleased: November 30, 2018Platforms: Microsoft Windows
- Bloons TD 6Released: December 17, 2018Developer: Ninja Kiwi
- Bloons Adventure Time TDReleased: January 16, 2019Series: Bloons Tower Defense
- Siege of CentauriReleased: September 12, 2019Developer: Stardock
- Type KnightReleased: October 24, 2019Engine: GameMaker
- ArknightsReleased: June 29, 2020Publisher: Long Cheng Network Co., Ltd., Ariel Co., Limited, Yostar, HyperGryph
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- GeminiReleased: September 23, 2020Platforms: Microsoft Windows
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- Elemental WarReleased: December 16, 2020Developer: Clockwork Origins
- DefentronReleased: December 17, 2020Publisher: Zerouno Games
- Element TD 2 - Multiplayer Tower DefenseReleased: April 2, 2021Platforms: Microsoft Windows
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- Time DefendersReleased: August 2021Developer: Nexciting
- JunkworldReleased: September 8, 2021Developer: Ironhide Game Studio
- JARSReleased: October 20, 2021Publisher: Daedalic Entertainment
- Defend the RookReleased: October 26, 2021Developer: One Up Plus
- Kingdom Rush Frontiers TD+Released: November 12, 2021Platforms: macOS
- Sky FleetReleased: December 17, 2021Publisher: Freedom Games
- Tunnel of DoomReleased: December 23, 2021Publisher: Digerati
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- Elemental War 2Released: May 6, 2022Developer: Clockwork Origins
- DwerveReleased: May 31, 2022Platforms: Microsoft Windows, macOS, Linux
- Blood And ZombiesReleased: July 26, 2022Publisher: Freedom Games
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- Path to NowhereReleased: October 27, 2022Platforms: Android
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- VoodollsReleased: May 11, 2023Platforms: Microsoft Windows
- ThronefallReleased: August 2, 2023Publisher: Mythwright
- AffogatoReleased: August 17, 2023Publisher: Spiral Up Games
- Diplomacy is Not an OptionReleased: October 4, 2024Developer: Door 407
- No Heroes Here 2Released: July 1, 2025Platforms: Microsoft Windows, Xbox Series X and Series S
- Orcs Must Die! DeathtrapReleased: July 29, 2025Developer: Robot Entertainment
- HIGH SCHOOL OF THE DEAD DAY 0Released: April 28, 2026Publisher: CTW Inc.
- Warcraft RumbleDeveloper: Blizzard EntertainmentPublisher: Blizzard Entertainment