- Battles of Prince of PersiaReleased: December 6, 2005Platforms: Nintendo DS
- Crazy Frog RacerReleased: December 9, 2005Developer: Neko Entertainment
- ExitReleased: December 15, 2005Developer: Taito
- Brain Age 2: More Training in Minutes a Day!Released: December 29, 2005Developer: Nintendo System Development
- Hannah MontanaReleased: 2006Platforms: Nintendo DS
- HorsezReleased: 2006Developer: MTO
- Mumin och de Mystiska VrålenReleased: 2006Platforms: Microsoft Windows, Nintendo DS
- My Pet HotelReleased: 2006Developer: Independent Arts Software
- Naruto: Ninja DestinyReleased: 2006Platforms: Nintendo DS
- Really? Really!Released: 2006Developer: Navel
- Super Collapse! 3Released: 2006Developer: GameHouse
- Tomb Raider: LegendReleased: 2006Developer: HumanSoft
- Top GunReleased: 2006Platforms: Nintendo DS
- Iron FeatherReleased: January 19, 2006Developer: Konami
- Bleach: The Blade of FateReleased: January 26, 2006Developer: Treasure
- English Training: Have Fun Improving Your Skills!Released: January 26, 2006Developer: Nintendo Software Planning & Development
- Age of Empires: The Age of KingsReleased: February 14, 2006Publisher: Majesco Entertainment
- Children of ManaReleased: March 2, 2006Developer: Square Enix
- Heracles: Battle with the GodsReleased: March 10, 2006Developer: Neko Entertainment
- Keroro Gunso: Enshū da Yo! Zenin ShūgōReleased: March 16, 2006Developer: Bandai
- Worms: Open WarfareReleased: March 22, 2006Developer: Team17
- Crayon Shin-Chan: Densetsu o Yobu - Omake no Miyako Shokkugān!Released: March 23, 2006Developer: Inti Creates
- Top Spin 2Released: March 29, 2006Developer: Indie Built
- Animal Crossing: Wild WorldReleased: March 31, 2006Developer: Nintendo Entertainment Analysis & Development
- Tenchu: Dark SecretReleased: April 6, 2006Developer: Polygon Magic
- Densetsu no Stafy 4Released: April 13, 2006Developer: Tose Co.
- City LifeReleased: April 14, 2006Developer: Monte Cristo
- 2006 FIFA World CupReleased: April 24, 2006Developer: EA Vancouver
- Guilty Gear Dust StrikersReleased: April 25, 2006Developer: Arc System Works
- Petz: Dogz 2Released: April 27, 2006Developer: MTO
- New Super Mario Bros.Released: May 15, 2006Developer: Nintendo
- Metroid Prime HuntersReleased: May 23, 2006Developer: Nintendo Software Technology
- Digimon World DSReleased: June 15, 2006Developer: Bandai Namco Holdings
- Metal Saga: Season of SteelReleased: June 15, 2006Developer: Crea-Tech
- Sudoku ManiaReleased: June 30, 2006Publisher: UFO Interactive Games
- Mega Man ZXReleased: July 6, 2006Developer: Inti Creates
- Milon no Hoshizora Shabon: Puzzle KumikyokuReleased: July 6, 2006Developer: Hudson Soft
- Virtual Villagers: A New HomeReleased: July 18, 2006Developer: Last Day of Work
- Bomberman Land Touch!Released: July 20, 2006Developer: Hudson Soft
- Crash Boom Bang!Released: July 20, 2006Developer: Dimps
- Tamagotchi Connection: Corner Shop 2Released: July 27, 2006Developer: NanaOn-Sha
- Star Fox CommandReleased: August 3, 2006Developer: Q-Games, Nintendo Entertainment Analysis & Development
- Tokimeki Memorial Girl's Side: 2nd KissReleased: August 3, 2006Developer: Konami
- Rune Factory: A Fantasy Harvest MoonReleased: August 24, 2006Developer: Neverland
- Freshly-Picked Tingle's Rosy RupeelandReleased: September 2, 2006Developer: Vanpool
- Lego Star Wars II: The Original TrilogyReleased: September 12, 2006Developer: Traveller's Tales
- MechAssault: Phantom WarReleased: September 12, 2006Series: MechWarrior
- Mind QuizReleased: September 14, 2006Platforms: Nintendo DS
- Cake ManiaReleased: September 15, 2006Developer: Sandlot Games
- Dragon Quest Heroes: Rocket SlimeReleased: September 19, 2006Developer: Tose Co.
- FIFA 07Released: September 25, 2006Developer: EA Vancouver
- Mario vs. Donkey Kong 2: March of the MinisReleased: September 25, 2006Developer: Nintendo Software Technology
- Kanken DSReleased: September 28, 2006Platforms: Nintendo DS
- Pokémon DiamondReleased: September 28, 2006Developer: Game Freak
- Pokémon PearlReleased: September 28, 2006Developer: Game Freak
- Avatar: The Last AirbenderReleased: October 10, 2006Developer: Tose Co., Halfbrick Studios, THQ Studio Australia
- The Legend of Spyro: A New BeginningReleased: October 10, 2006Developer: The Mighty Troglodytes, Krome Studios, Amaze Entertainment
- Custom Robo ArenaReleased: October 19, 2006Developer: Noise
- Nacho LibreReleased: October 24, 2006Developer: Budcat Creations
- Tony Hawk's Downhill JamReleased: October 24, 2006Platforms: Nintendo DS, Wii
- Tales of the TempestReleased: October 26, 2006Developer: Dimps
- Pro Evolution Soccer 6Released: October 27, 2006Developer: Konami
- The Sims 2: Pets (Nintendo DS)Released: October 27, 2006Developer: Maxis
- Kirby: Squeak SquadReleased: November 2, 2006Developer: Flagship
- Elite Beat AgentsReleased: November 6, 2006Developer: INiS
- Winx Club: Quest for the CodexReleased: November 6, 2006Developer: Powerhead Games
- My Frogger Toy TrialsReleased: November 13, 2006Developer: Konami
- Yoshi's Island DSReleased: November 13, 2006Developer: Artoon
- Backyard Basketball 2007Released: November 14, 2006Developer: Atari
- Bionicle HeroesReleased: November 14, 2006Developer: TT Games
- Rayman Raving RabbidsReleased: November 14, 2006Platforms: Nintendo DS
- Spider-Man: Battle for New YorkReleased: November 14, 2006Developer: Torus Games
- Castlevania: Portrait of RuinReleased: November 16, 2006Developer: Konami
- Puzzle Series Vol. 5: SlitherlinkReleased: November 16, 2006Series: Puzzle Series
- Runaway 2: The Dream of the TurtleReleased: November 17, 2006Developer: Pendulo Studios, S.L.
- Totally Spies! 2: UndercoverReleased: November 17, 2006Developer: Mistic Software
- Rayman Raving RabbidsReleased: November 19, 2006Engine: Jade
- Lunar KnightsReleased: November 22, 2006Series: Boktai
- Flushed AwayReleased: December 1, 2006Developer: Monkey Bar Games, Altron, Art Co., Ltd
- Inukami! feat. AnimationReleased: December 7, 2006Developer: ASCII Media Works
- Madden NFL 07Released: December 7, 2006Developer: EA Orlando
- Pokémon RangerReleased: December 7, 2006Developer: HAL Laboratory
- Need for Speed: CarbonReleased: December 8, 2006Developer: EA Vancouver
- Final Fantasy Fables: Chocobo TalesReleased: December 14, 2006Developer: H.a.n.d.
- Mega Man Star ForceReleased: December 14, 2006Developer: Capcom
- Puyo Puyo! 15th AnniversaryReleased: December 14, 2006Developer: Sonic Team
- Dragon Quest Monsters: JokerReleased: December 28, 2006Developer: Tose Co.
- Imagine BabyzReleased: 2007Series: Imagine
- Jake Hunter Detective Story: Memories of the PastReleased: 2007Platforms: Nintendo DS
- Meteos: Disney MagicReleased: 2007Platforms: Nintendo DS
- Mumin och den Stora HöstfestenReleased: 2007Publisher: Nordic Softsales
- Paws & Claws: Best Friends - Dogs & CatsReleased: 2007Developer: Sproing Interactive Media
- Puzzle Series Vol. 11: NurikabeReleased: 2007Series: Puzzle Series
- Riding Star 3Released: 2007Platforms: Nintendo DS
- The Half Broken Crown: The Broken KingdomsReleased: 2007Developer: NextGenBooks
- Toon-DokuReleased: 2007Platforms: Nintendo DS
- Yu-Gi-Oh! World Championship 2007Released: 2007Developer: Konami
- Yu-Gi-Oh! GX Spirit CallerReleased: January 2, 2007Platforms: Nintendo DS
- Iriya no Sora, UFO no NatsuReleased: January 11, 2007Platforms: Nintendo DS
- Pixeline i PixielandReleased: January 11, 2007Developer: Krea Medie