- Etrian OdysseyReleased: January 18, 2007Series: Etrian Odyssey
- Wario: Master of DisguiseReleased: January 18, 2007Developer: Suzak Inc.
- Harvest Moon DS: Island of HappinessReleased: February 1, 2007Developer: Marvelous Entertainment
- 7 Wonders of the Ancient WorldReleased: February 2, 2007Developer: Hot Lava Games
- Diddy Kong Racing DSReleased: February 5, 2007Platforms: Nintendo DS
- Luminous ArcReleased: February 8, 2007Developer: Imageepoch
- Kim Possible: Global GeminiReleased: February 13, 2007Publisher: Disney Interactive Studios
- Bleach: Dark SoulsReleased: February 15, 2007Developer: Treasure
- Professor Layton and the Curious VillageReleased: February 15, 2007Developer: Level-5
- CatzReleased: February 22, 2007Developer: Powerhead Games, ImaginEngine
- SimCity DSReleased: February 22, 2007Developer: Electronic Arts
- PeggleReleased: February 27, 2007Publisher: Valve Corporation
- Super Robot Wars WReleased: March 1, 2007Developer: Banpresto
- Desktop Tower DefenseReleased: March 3, 2007Engine: Adobe Flash
- Heroes of ManaReleased: March 8, 2007Developer: Square Enix
- SpectrobesReleased: March 13, 2007Developer: Jupiter
- Bomberman Story DSReleased: March 21, 2007Developer: Hudson Soft
- TMNTReleased: March 22, 2007Developer: Ubisoft Quebec
- Bubble Bobble Double ShotReleased: March 23, 2007Series: Bubble Bobble
- Dynasty Warriors DS: Fighter's BattleReleased: April 5, 2007Developer: Koei
- Apollo Justice: Ace AttorneyReleased: April 12, 2007Developer: Capcom
- Atelier Lise: The Alchemist of OrdeReleased: April 19, 2007Developer: Gust Co. Ltd.
- Gakuen Alice: Waku Waku Happy FriendsReleased: April 19, 2007Platforms: Nintendo DS
- Final Fantasy XII: Revenant WingsReleased: April 26, 2007Publisher: Square Enix
- Planet Puzzle LeagueReleased: April 26, 2007Developer: Intelligent Systems
- Code LyokoReleased: May 15, 2007Publisher: The Game Factory
- Moero! Nekketsu Rhythm Damashii Osu! Tatakae! Ouendan 2Released: May 17, 2007Developer: INiS
- Death Jr. and the Science Fair of DoomReleased: May 22, 2007Publisher: Konami
- Diner Dash: Flo on the GoReleased: June 4, 2007Developer: Amazon
- Mizuiro BloodReleased: June 14, 2007Developer: Bandai Namco Entertainment
- Itadaki Street DSReleased: June 21, 2007Developer: Armor Project
- The Legend of Zelda: Phantom HourglassReleased: June 23, 2007Developer: Nintendo Entertainment Analysis & Development
- TouchMasterReleased: June 25, 2007Developer: Midway Games
- River King: Mystic ValleyReleased: June 28, 2007Platforms: Nintendo DS
- Chibi-Robo!: Park PatrolReleased: July 5, 2007Developer: Skip Ltd.
- Doki Doki Majo Shinpan!Released: July 5, 2007Developer: SNK
- Cosmetic ParadiseReleased: July 19, 2007Developer: Global A Entertainment
- Jake Hunter: Detective ChroniclesReleased: July 19, 2007Platforms: Nintendo DS
- DK Jungle ClimberReleased: August 9, 2007Developer: Paon DP
- Hisui no Shizuku: Hiiro no Kakera 2Released: August 9, 2007Developer: Otomate, Design Factory
- High School Musical: Makin' the Cut!Released: August 14, 2007Publisher: Disney Interactive Studios
- Final Fantasy Crystal Chronicles: Ring of FatesReleased: August 23, 2007Developer: Square Enix
- The Wild WestReleased: August 28, 2007Developer: Happy Happening
- Madden NFL 08Released: August 30, 2007Developer: EA Orlando
- Summon Night: Twin AgeReleased: August 30, 2007Developer: Flight-Plan
- Worms: Open Warfare 2Released: August 30, 2007Developer: Team17
- Backyard HockeyReleased: September 7, 2007Developer: Humongous Entertainment
- Drawn to LifeReleased: September 10, 2007Developer: 5th Cell
- Sonic Rush AdventureReleased: September 14, 2007Developer: Sonic Team
- Juiced 2: Hot Import NightsReleased: September 17, 2007Developer: THQ Digital Studios UK
- Namco Museum DSReleased: September 18, 2007Developer: M2
- Race Driver: Create & RaceReleased: September 25, 2007Developer: Firebrand Games
- FIFA 08Released: September 27, 2007Developer: EA Vancouver
- Jigoku Shōjo: AkekazuraReleased: September 27, 2007Platforms: Nintendo DS
- Tamagotchi Connection: Corner Shop 3Released: September 27, 2007Developer: NanaOn-Sha
- Hot Wheels: Beat That!Released: September 30, 2007Developer: Eutechnyx
- Spider-Man: Friend or FoeReleased: October 2, 2007Developer: Next Level Games
- Imagine: Animal DoctorReleased: October 12, 2007Series: Imagine
- Real Football 2008Released: October 12, 2007Developer: Gameloft
- The Bee GameReleased: October 15, 2007Developer: Independent Arts Software
- Tony Hawk's Proving GroundReleased: October 15, 2007Platforms: PlayStation 3, Nintendo DS, Wii
- The Legend of Spyro: The Eternal NightReleased: October 18, 2007Developer: The Mighty Troglodytes, Krome Studios, Amaze Entertainment
- The Sims 2: CastawayReleased: October 22, 2007Developer: Electronic Arts
- The Sims 2: CastawayReleased: October 22, 2007Developer: Full Fat
- Backyard Football '08Released: October 23, 2007Developer: Humongous Entertainment
- Mega Man ZX AdventReleased: October 23, 2007Developer: Inti Creates
- Final Fantasy Tactics A2: Grimoire of the RiftReleased: October 25, 2007Developer: Square Enix
- Iriya no Sora, UFO no Natsu IIReleased: October 25, 2007Platforms: Nintendo DS
- The KoshojinReleased: October 25, 2007Series: Simple DS Series
- Avatar: The Last Airbender – The Burning EarthReleased: October 26, 2007Developer: THQ
- Pro Evolution Soccer 2008Released: October 26, 2007Developer: Konami
- Cars Mater-National ChampionshipReleased: October 29, 2007Developer: THQ
- Chessmaster: The Art of LearningReleased: October 30, 2007Developer: Ubisoft Romania, Ubisoft Sofia
- The Simpsons GameReleased: October 30, 2007Developer: Celbridge
- Top Gear: DownforceReleased: October 31, 2007Developer: Tantalus Media
- Call of Duty 4: Modern WarfareReleased: November 5, 2007Developer: N-Space
- My French Coach and My Spanish CoachReleased: November 6, 2007Developer: Sensory Sweep Studios
- Puzzle de Harvest MoonReleased: November 6, 2007Series: Story of Seasons
- Mario Party DSReleased: November 8, 2007Developer: Hudson Soft
- Tiger Woods PGA Tour 08Released: November 8, 2007Developer: EA Orlando
- Yggdra UnisonReleased: November 11, 2007Developer: Sting
- Cooking Mama 2: Dinner with FriendsReleased: November 13, 2007Developer: Cooking Mama Limited
- Need for Speed: ProStreetReleased: November 14, 2007Developer: EA Vancouver
- Rayman Raving Rabbids 2Released: November 15, 2007Engine: Jade
- CSI: Dark MotivesReleased: November 20, 2007Developer: Radical Entertainment, Powerhead Games
- Kōenji Joshi Soccer 2Released: November 22, 2007Platforms: Nintendo DS
- Mario & Sonic at the Olympic GamesReleased: November 22, 2007Developer: Sega Sports R&D
- Mega Man Star Force 2Released: November 22, 2007Developer: Capcom
- Professor Layton and the Diabolical BoxReleased: November 29, 2007Developer: Level-5
- Alvin and the ChipmunksReleased: December 4, 2007Developer: Sensory Sweep Studios
- Tales of InnocenceReleased: December 6, 2007Developer: Alfa System
- Contra 4Released: December 12, 2007Developer: WayForward Technologies
- Final Fantasy Fables: Chocobo's DungeonReleased: December 13, 2007Developer: H.a.n.d.
- Imagine: Ice ChampionsReleased: December 13, 2007Developer: Spike
- Showtime Championship BoxingReleased: December 13, 2007Developer: Nikitova Games
- Ultimate Mortal KombatReleased: December 13, 2007Developer: Other Ocean
- Final Fantasy IVReleased: December 20, 2007Developer: Square Enix
- 4 ElementsReleased: 2008Developer: Playrix
- Dancing with the Stars: We Dance!Released: 2008Developer: Zoë Mode
- Derby Stallion DSReleased: 2008Platforms: Nintendo DS