- Guitar Hero On Tour: DecadesReleased: 2008Series: Guitar Hero
- Hajime no Ippo: The Fighting! DSReleased: 2008Platforms: Nintendo DS
- Homie RollerzReleased: 2008Platforms: Nintendo DS
- Imagine TeacherReleased: 2008Series: Imagine
- Imagine: Ballet StarReleased: 2008Developer: Spike
- Mushroom Men: Rise of the FungiReleased: 2008Platforms: Nintendo DS
- Nadia MegafunlandReleased: 2008Platforms: Nintendo DS
- Tootuff: MegafunlandReleased: 2008Platforms: Nintendo DS
- Rune Factory 2Released: January 3, 2008Developer: Neverland
- Advance Wars: Days of RuinReleased: January 25, 2008Developer: Intelligent Systems
- Houkago ShounenReleased: January 31, 2008Platforms: Nintendo DS
- Assassin's Creed: Altaïr's ChroniclesReleased: February 5, 2008Developer: Gameloft
- Zoo Tycoon 2 DSReleased: February 5, 2008Developer: Blue Fang Games
- Puzzle Quest: Challenge of the WarlordsReleased: February 8, 2008Developer: 1st Playable Productions, Infinity Plus Two
- Digimon World ChampionshipReleased: February 14, 2008Developer: Bandai Namco Entertainment
- WWE SmackDown vs. Raw 2008Released: February 14, 2008Developer: Yuke's
- Totally Spies! 3: Secret AgentReleased: February 15, 2008Developer: Ouat Entertainment
- Etrian Odyssey IIReleased: February 21, 2008Series: Etrian Odyssey
- Populous DSReleased: February 21, 2008Developer: Genki
- Space Invaders ExtremeReleased: February 21, 2008Developer: Taito
- TigerzReleased: February 26, 2008Developer: Magic Pockets
- MX vs. ATV UntamedReleased: March 7, 2008Developer: Incinerator Studios
- Winx Club: Mission EnchantixReleased: March 7, 2008Publisher: Konami
- Shugo Chara! 3-tsu no Tamago to Koisuru JokerReleased: March 13, 2008Platforms: Nintendo DS
- The Water Horse: Legend of the DeepReleased: March 14, 2008Developer: Atomic Planet Entertainment
- Sega Superstars TennisReleased: March 18, 2008Developer: Sumo Digital
- SimCity DS 2Released: March 19, 2008Developer: Syn Sophia
- Bakusou Dekotora Densetsu BlackReleased: March 20, 2008Series: Bakusō Dekotara Densetsu
- Ninja Gaiden: Dragon SwordReleased: March 20, 2008Developer: Team Ninja
- Pokémon Ranger: Shadows of AlmiaReleased: March 20, 2008Developer: Creatures
- Rosario + Vampire: Tanabata's Miss Yokai AcademyReleased: March 20, 2008Developer: Capcom
- Lego Star Wars: The Complete SagaReleased: March 27, 2008Developer: Traveller's Tales, Feral Interactive
- Fossil FightersReleased: April 17, 2008Developer: Nintendo Software Planning & Development
- The World Ends with YouReleased: April 18, 2008Developer: Square Enix, Jupiter, H.a.n.d.
- Metcha! Taiko no Tatsujin DS: Nanatsu no Shima no DaiboukenReleased: April 24, 2008Developer: Namco
- Luminous Arc 2Released: May 15, 2008Developer: Imageepoch
- Glory of HeraclesReleased: May 22, 2008Developer: Paon DP
- Luxor 2Released: May 30, 2008Developer: MumboJumbo
- 99 no NamidaReleased: June 5, 2008Publisher: Bandai Namco Entertainment
- The Incredible HulkReleased: June 5, 2008Engine: GameMaker
- Lego Indiana Jones: The Original AdventuresReleased: June 6, 2008Developer: Traveller's Tales
- Breath: Toiki wa AkaneiroReleased: June 12, 2008Publisher: Success
- My World, My WayReleased: June 12, 2008Developer: Global A Entertainment
- Civilization RevolutionReleased: June 13, 2008Developer: Firaxis Games
- Code Lyoko: Fall of X.A.N.A.Released: June 20, 2008Developer: Neko Entertainment
- My Weight Loss CoachReleased: June 20, 2008Series: My Coach
- Top Spin 3Released: June 20, 2008Developer: PAM Development
- Guitar Hero: On TourReleased: June 22, 2008Series: Guitar Hero
- American Girl: Kit Mystery Challenge!Released: June 23, 2008Developer: Webfoot Technologies
- Bleach: The 3rd PhantomReleased: June 26, 2008Platforms: Nintendo DS
- Wacky Races: Crash and DashReleased: June 27, 2008Developer: Eidos Interactive
- Trauma Center: Under the Knife 2Released: July 1, 2008Series: Trauma Center
- The Bakudan ShorihanReleased: July 10, 2008Developer: Tomcat System
- Metal Slug 7Released: July 22, 2008Developer: SNK
- Dokapon JourneyReleased: July 31, 2008Developer: Suzak Inc.
- Doki Doki Majo Shinpan 2 DuoReleased: July 31, 2008Developer: SNK
- Hayarigami 2: Keishichō Kaii Jiken FileReleased: August 7, 2008Platforms: Nintendo DS, PlayStation Portable
- Madden NFL 09Released: August 15, 2008Developer: EA Orlando
- Inazuma ElevenReleased: August 22, 2008Developer: Level-5
- The Sims 2: Apartment PetsReleased: August 26, 2008Developer: Electronic Arts
- The Mummy: Tomb of the Dragon EmperorReleased: August 28, 2008Developer: Eurocom
- Spore CreaturesReleased: September 7, 2008Developer: EA Mobile, Griptonite Games, Foundation 9 Entertainment
- Mystery Case Files: MillionHeirReleased: September 8, 2008Developer: Big Fish Games
- Real Football 2009Released: September 8, 2008Developer: Gameloft
- Viva Piñata: Pocket ParadiseReleased: September 8, 2008Developer: Rare Ltd.
- Pokémon PlatinumReleased: September 13, 2008Developer: Game Freak
- Drawn to Life: SpongeBob SquarePants EditionReleased: September 15, 2008Developer: Altron
- Ankh: Curse of the Scarab KingReleased: September 17, 2008Developer: VIS Entertainment
- Dragon Ball: OriginsReleased: September 18, 2008Developer: Game Republic
- Kirby Super Star UltraReleased: September 22, 2008Developer: HAL Laboratory
- My Little Pony: Pinkie Pie's PartyReleased: September 22, 2008Developer: Webfoot Technologies
- Lego Batman: The VideogameReleased: September 23, 2008Developer: Traveller's Tales
- My SAT CoachReleased: September 23, 2008Series: My Coach
- Knights in the NightmareReleased: September 25, 2008Developer: Sting
- Sonic Chronicles: The Dark BrotherhoodReleased: September 25, 2008Developer: Bioware
- So BlondeReleased: September 26, 2008Developer: Wizarbox
- FIFA 09Released: October 2, 2008Developer: EA Vancouver
- MLB Power Pros 2008Released: October 2, 2008Developer: Konami
- Spectrobes: Beyond the PortalsReleased: October 7, 2008Developer: Jupiter
- Star Wars: The Force UnleashedReleased: October 9, 2008Developer: Lucasfilm Games
- Tak: Mojo MistakeReleased: October 13, 2008Developer: THQ
- Littlest Pet ShopReleased: October 14, 2008Developer: EA Salt Lake
- Tetris PartyReleased: October 14, 2008Developer: Hudson Soft
- Rock RevolutionReleased: October 15, 2008Developer: Zoë Mode
- SpongeBob SquarePants featuring Nicktoons: Globs of DoomReleased: October 20, 2008Developer: Incinerator Studios
- Backyard Football '09Released: October 21, 2008Developer: Humongous Entertainment
- Castlevania: Order of EcclesiaReleased: October 21, 2008Developer: Konami
- High School Musical 3: Senior YearReleased: October 21, 2008Developer: Griptonite Games
- Mechanic MasterReleased: October 21, 2008Publisher: Midway Home Entertainment
- TouchMaster 2Released: October 21, 2008Publisher: Midway Games
- Bejeweled TwistReleased: October 27, 2008Series: Bejeweled
- MySimsReleased: October 28, 2008Developer: Visceral Games, Tose Co., Babaroga
- Shrek's Carnival CrazeReleased: October 28, 2008Developer: Nordcurrent
- Martin Mystery: Monster InvasionReleased: October 30, 2008Platforms: Nintendo DS
- Crash: Mind over MutantReleased: October 31, 2008Developer: Radical Entertainment
- Avalon CodeReleased: November 2008Developer: Matrix Software
- Valkyrie Profile: Covenant of the PlumeReleased: November 1, 2008Developer: Tri-Ace
- Madagascar: Escape 2 AfricaReleased: November 4, 2008Developer: Toys for Bob
- The Legend of Spyro: Dawn of the DragonReleased: November 5, 2008Developer: The Mighty Troglodytes, Étranges Libellules
- Shugo Chara! Amu no Niji-iro Chara ChangeReleased: November 6, 2008Platforms: Nintendo DS