- FIFA 10Released: October 2009Developer: EA Vancouver
- The Biggest LoserReleased: October 6, 2009Platforms: Nintendo DS
- Drawn to Life: The Next ChapterReleased: October 8, 2009Developer: 5th Cell
- Shin Megami Tensei: Strange JourneyReleased: October 8, 2009Series: Megami Tensei
- Spore Hero ArenaReleased: October 8, 2009Developer: Maxis
- Mario & Luigi: Bowser's Inside StoryReleased: October 9, 2009Developer: AlphaDream
- The Legendary StarfyReleased: October 10, 2009Developer: Tose Co.
- Real Football 2010Released: October 11, 2009Developer: Gameloft
- Cars Race-O-RamaReleased: October 12, 2009Developer: Incinerator Studios
- Mario & Sonic at the Olympic Winter GamesReleased: October 16, 2009Developer: Sonic Team, Racjin
- Cooking Mama 3: Shop & ChopReleased: October 20, 2009Developer: Taito
- Marvel Super Hero SquadReleased: October 20, 2009Developer: Blue Tongue Entertainment
- Rune Factory 3Released: October 22, 2009Developer: Neverland
- Brain Age Express: Arts & LettersReleased: October 23, 2009Developer: Nintendo System Development
- Style SavvyReleased: October 23, 2009Developer: Syn Sophia
- SpongeBob's Truth or SquareReleased: October 26, 2009Developer: Heavy Iron Studios
- The BackyardigansReleased: October 26, 2009Developer: Black Lantern Studios, Inc.
- ICarlyReleased: October 27, 2009Developer: Blitz Games
- TouchMaster 3Released: October 27, 2009Platforms: Nintendo DS
- Final Fantasy: The 4 Heroes of LightReleased: October 29, 2009Developer: Matrix Software
- Angel Cat SugarReleased: October 30, 2009Publisher: Rising Star Games
- Band HeroReleased: November 3, 2009Developer: Neversoft
- Lego Rock BandReleased: November 3, 2009Developer: Harmonix Music Systems, TT Fusion
- Star Wars Battlefront: Elite SquadronReleased: November 3, 2009Developer: Rebellion Developments, N-Space
- Summon Night X: Tears CrownReleased: November 5, 2009Developer: Flight-Plan
- Jambo! SafariReleased: November 6, 2009Developer: Sega AM2
- Madagascar KartzReleased: November 6, 2009Developer: Sidhe
- Rabbids Go HomeReleased: November 6, 2009Series: Raving Rabbids
- Call of Duty: Modern Warfare: MobilizedReleased: November 10, 2009Developer: N-Space
- Harvest Moon DS: Sunshine IslandsReleased: November 10, 2009Developer: Marvelous Entertainment
- Hot Wheels Battle Force 5Released: November 10, 2009Developer: Sidhe
- My Baby 2Released: November 11, 2009Developer: Dancing Dots
- CSI: Deadly IntentReleased: November 12, 2009Developer: Telltale Games, Other Ocean
- Rockman EXE Operate Shooting StarReleased: November 12, 2009Developer: Capcom
- Assassin's Creed II: DiscoveryReleased: November 17, 2009Developer: Griptonite Games
- The Princess and the FrogReleased: November 17, 2009Developer: Griptonite Games
- Ghostbusters: The Video GameReleased: November 19, 2009Developer: Red Fly Studio, Terminal Reality
- Lego Indiana Jones 2: The Adventure ContinuesReleased: November 20, 2009Developer: TT Fusion
- Professor Layton and the Last SpecterReleased: November 26, 2009Developer: Level-5
- Runaway: A Twist of FateReleased: November 26, 2009Developer: Pendulo Studios, S.L.
- Teenage Mutant Ninja Turtles: Arcade AttackReleased: November 27, 2009Developer: Ubisoft Nagoya
- Might & Magic: Clash of HeroesReleased: December 2009Developer: Capybara Games
- MX vs. ATV ReflexReleased: December 1, 2009Developer: Rainbow Studios
- Cross TreasuresReleased: December 3, 2009Platforms: Nintendo DS
- Kirakira Rythm CollectionReleased: December 3, 2009Platforms: Nintendo DS
- The Legend of Zelda: Spirit TracksReleased: December 7, 2009Developer: Nintendo Entertainment Analysis & Development
- KuruKuru Princess: Tokimeki Figure Mezase! VancouverReleased: December 10, 2009Developer: Spike
- Luminous Arc 3Released: December 10, 2009Developer: Imageepoch
- Nine Hours, Nine Persons, Nine DoorsReleased: December 10, 2009Developer: Chunsoft
- Need for Speed: NitroReleased: December 17, 2009Developer: Firebrand Games
- Deal or No Deal: Special EditionReleased: 2010Developer: Mad Monkey Studio
- ECrew Development ProgramReleased: 2010Platforms: Nintendo DS
- GoldenEye 007Released: 2010Developer: N-Space
- Sonic ColorsReleased: 2010Platforms: Nintendo DS
- TouchMaster: ConnectReleased: 2010Platforms: Nintendo DS
- Max & the Magic MarkerReleased: January 22, 2010Developer: Press Play
- WWE SmackDown vs. Raw 2010Released: January 28, 2010Developer: Yuke's
- Dragon Ball: Origins 2Released: February 11, 2010Developer: Game Republic
- Lupin III: Shijō Saidai no ZunōsenReleased: February 11, 2010Publisher: Bandai Namco Entertainment
- Imagine: Makeup ArtistReleased: February 12, 2010Developer: Global A Entertainment
- Diner DashReleased: February 16, 2010Developer: Gamelab
- Sonic & Sega All-Stars RacingReleased: February 23, 2010Developer: Sumo Digital
- Lufia: Curse of the SinistralsReleased: February 25, 2010Developer: Neverland
- Shiren the Wanderer 4: The Eye of God and the Devil's NavelReleased: February 25, 2010Developer: Chunsoft
- Super Robot Taisen OG Saga: Endless FrontierReleased: February 25, 2010Developer: Monolith Soft Inc., Banpresto
- Winx Club: Believix in YouReleased: February 26, 2010Platforms: Nintendo DS
- Combat of Giants: Mutant InsectsReleased: March 2, 2010Developer: Ubisoft Quebec
- Sonic Classic CollectionReleased: March 2, 2010Developer: Creative Assembly
- Keroro RPG: Kishi to Musha to Densetsu no KaizokuReleased: March 4, 2010Developer: Namco Tales Studio
- Picross 3DReleased: March 5, 2010Developer: HAL Laboratory
- Pokémon Ranger: Guardian SignsReleased: March 6, 2010Developer: Creatures
- Sengoku SpiritsReleased: March 18, 2010Developer: Tasuke
- Etrian Odyssey IIIReleased: April 1, 2010Series: Etrian Odyssey
- AlphaBounceReleased: April 9, 2010Developer: Motion Twin
- Soukoku no Kusabi: Hiiro no Kakera 3Released: April 15, 2010Developer: Design Factory
- Dragon Quest Monsters: Joker 2Released: April 28, 2010Developer: Tose Co.
- Iron Man 2Released: April 29, 2010Developer: Sega Studios San Francisco
- Shrek Forever AfterReleased: May 18, 2010Developer: XPEC Entertainment
- Captain Tsubasa: New Kick OffReleased: May 20, 2010Developer: Konami
- Backyard Sports: Sandlot SluggersReleased: May 25, 2010Developer: HB Studios, Powerhead Games
- Puzzle Quest 2Released: June 22, 2010Developer: Infinity Plus Two
- Secret Files: TunguskaReleased: June 22, 2010Developer: Animation Arts
- Sherlock Holmes and the Mystery of Osborne HouseReleased: June 24, 2010Developer: Frogwares
- Tokimeki Memorial Girl's Side: 3rd StoryReleased: June 24, 2010Developer: Konami
- Lego Harry Potter: Years 1–4Released: June 29, 2010Developer: Traveller's Tales
- Digimon Story Lost EvolutionReleased: July 1, 2010Developer: Bandai Namco Entertainment
- Inazuma Eleven 3Released: July 1, 2010Developer: Level-5
- Taiko no Tatsujin DS: Dororon! Yokai Daikessen!!Released: July 1, 2010Developer: Namco
- Harry Potter and the Half-Blood PrinceReleased: July 3, 2010Developer: Electronic Arts
- Harvest Moon: The Tale of Two TownsReleased: July 8, 2010Developer: Marvelous Entertainment
- Fire Emblem: New Mystery of the EmblemReleased: July 15, 2010Developer: Intelligent Systems
- The Gal MahjongReleased: July 28, 2010Developer: HuneX
- Metal Max 3Released: July 29, 2010Developer: Cattle Call
- Monster Rancher DSReleased: August 3, 2010Developer: Cing
- Harvest Moon DS: Grand BazaarReleased: August 24, 2010Developer: Marvelous Entertainment
- Batman: The Brave and the Bold – The VideogameReleased: September 7, 2010Developer: WayForward Technologies
- Pokémon BlackReleased: September 18, 2010Developer: Game Freak
- Pokémon WhiteReleased: September 18, 2010Developer: Game Freak
- TrackMania TurboReleased: September 23, 2010Developer: Firebrand Games
- FIFA 11Released: September 28, 2010Developer: EA Vancouver