- WWE SmackDown vs. Raw 2009Released: November 6, 2008Developer: Yuke's
- Call of Duty: World at WarReleased: November 11, 2008Developer: N-Space
- Mega Man Star Force 3Released: November 13, 2008Developer: Capcom
- Rayman Raving Rabbids: TV PartyReleased: November 13, 2008Developer: Ubisoft Paris
- Totally Spies! 4Released: November 13, 2008Developer: Ouat Entertainment
- Kingdom Hearts CodedReleased: November 18, 2008Developer: Square Enix
- Tomb Raider: UnderworldReleased: November 18, 2008Developer: Crystal Dynamics
- Tony Hawk's MotionReleased: November 18, 2008Developer: Creat Studios
- Skate ItReleased: November 19, 2008Developer: EA Montreal
- Need for Speed: UndercoverReleased: November 20, 2008Series: Need for Speed
- Hello Kitty: Big City DreamsReleased: November 28, 2008Developer: Sanrio
- Moto Racer DSReleased: November 28, 2008Publisher: SouthPeak Games
- My Fun Facts CoachReleased: December 2, 2008Developer: Powerhead Games
- Prince of Persia: The Fallen KingReleased: December 2, 2008Developer: Ubisoft Casablanca
- Bomberman 2 DSReleased: December 4, 2008Developer: Hudson Soft
- Top Trumps: Doctor WhoReleased: December 5, 2008Developer: Team 3 Games, Rockpool Games
- Hiiro no KakeraReleased: December 18, 2008Developer: Otomate, Design Factory
- Ragnarok DSReleased: December 18, 2008Developer: GungHo Online Entertainment
- Space Bust-a-MoveReleased: December 18, 2008Series: Puzzle Bobble
- Tales of HeartsReleased: December 18, 2008Developer: Namco Tales Studio
- Brain Age Express: MathReleased: December 24, 2008Developer: Nintendo System Development
- Phantasy Star 0Released: December 25, 2008Developer: Sonic Team
- 1912 Titanic MysteryReleased: 2009Developer: Mad Data
- Astrology DS: The Stars in Your HandReleased: 2009Developer: Sproing Interactive Media
- Atelier Lina: The Alchemist of StrahlReleased: 2009Developer: Gust Co. Ltd.
- DelboReleased: 2009Developer: Beyond Interactive
- Discovery Kids: Dolphin DiscoveryReleased: 2009Platforms: Nintendo DS
- Don King BoxingReleased: 2009Platforms: Nintendo DS
- Guitar Hero On Tour: Modern HitsReleased: 2009Series: Guitar Hero
- Jam Sessions 2Released: 2009Platforms: Nintendo DS
- Naruto: Ninja Destiny 2Released: 2009Platforms: Nintendo DS
- The Oregon TrailReleased: 2009Developer: Gameloft
- Pixeline: Magi i PixielandReleased: January 6, 2009Developer: Krea Medie
- The Lord of the Rings: ConquestReleased: January 9, 2009Developer: Pandemic Studios
- Shin Megami Tensei: Devil SurvivorReleased: January 15, 2009Series: Megami Tensei
- Monster RacersReleased: January 22, 2009Developer: Koei
- Mr BeanReleased: February 6, 2009Developer: Beyond Reality Games
- Shining Force FeatherReleased: February 19, 2009Developer: Flight-Plan
- Puzzle Quest: GalactrixReleased: February 24, 2009Developer: Infinity Plus Two
- Army Men: Soldiers of MisfortuneReleased: February 27, 2009Developer: Big Blue Bubble
- 7th DragonReleased: March 5, 2009Developer: Imageepoch
- KimokawaE!Released: March 5, 2009Platforms: Nintendo DS
- Atelier Annie: Alchemists of Sera IslandReleased: March 12, 2009Developer: Gust Co. Ltd.
- MySims PartyReleased: March 12, 2009Developer: Hudson Soft, Visceral Games
- Wiffle BallReleased: March 12, 2009Platforms: Nintendo DS
- Broken Sword: Shadow of the Templars – The Director's CutReleased: March 19, 2009Developer: Revolution Software
- Gardening MamaReleased: March 19, 2009Developer: Cooking Mama Limited
- The Treasures of MontezumaReleased: March 24, 2009Platforms: PlayStation 3, Microsoft Windows, Nintendo DS, PlayStation Portable, PlayStation Vita, Windows Phone, Android
- 007: Quantum of SolaceReleased: March 26, 2009Developer: Treyarch
- Space Invaders Extreme 2Released: March 26, 2009Publisher: Taito
- Spin SixReleased: April 2009Developer: Zener Works
- Final Fantasy Crystal Chronicles: Echoes of TimeReleased: April 2, 2009Developer: Square Enix
- Giana Sisters DSReleased: April 3, 2009Developer: Spellbound Entertainment
- Doodle JumpReleased: April 6, 2009Developer: Lima Sky
- Pokémon Mystery Dungeon: Explorers of SkyReleased: April 18, 2009Developer: Chunsoft
- A-Train DSReleased: April 23, 2009Series: A-Train
- Another Time Another Leaf: Kagami no Naka no TanteiReleased: April 23, 2009Publisher: Arc System Works
- Dragon Ball Z: Attack of the SaiyansReleased: April 29, 2009Developer: Monolith Soft Inc.
- WarioWare D.I.Y.Released: April 29, 2009Developer: Intelligent Systems, Nintendo Software Planning & Development
- X-Men Origins: WolverineReleased: May 1, 2009Developer: Raven Software
- Adventures of PinocchioReleased: May 8, 2009Developer: Phoenix Games Ltd.
- Secret Files 2: Puritas CordisReleased: May 8, 2009Developer: Animation Arts
- The Saiban'in ~Hitotsu no Shinjitsu, Muttsu no Kotae~Released: May 21, 2009Developer: WITCHCRAFT inc.
- A Witch's TaleReleased: May 28, 2009Publisher: Nippon Ichi Software
- Ace Attorney Investigations: Miles EdgeworthReleased: May 28, 2009Developer: Capcom
- The Series of Haruhi SuzumiyaReleased: May 28, 2009Developer: Cavia
- Kingdom Hearts 358/2 DaysReleased: May 30, 2009Developer: Square Enix
- Naruto Shippuden: Ninja Council 4Released: June 2, 2009Developer: Aspect
- The Sims 3Released: June 2, 2009Developer: The Sims Studio, Maxis, EA Mobile, Edge of Reality
- Rhythm HeavenReleased: June 4, 2009Developer: Nintendo Software Planning & Development, TNX
- Totally Spies! Mon Agenda SecretReleased: June 4, 2009Developer: Ouat Entertainment
- Lego BattlesReleased: June 9, 2009Developer: Hellbent Games
- Hayarigami: Keishichō Kaii Jiken FileReleased: June 11, 2009Platforms: Nintendo DS, PlayStation Portable
- Witch's WishReleased: June 11, 2009Developer: Tamsoft
- MySims RacingReleased: June 18, 2009Series: MySims
- Tomodachi CollectionReleased: June 18, 2009Developer: Nintendo Software Planning & Development
- AFL Mascot ManorReleased: July 2, 2009Developer: Wicked Witch Software
- NRL Mascot ManiaReleased: July 2, 2009Developer: Wicked Witch Software
- Dragon Quest IXReleased: July 11, 2009Developer: Level-5
- Okaeri! Chibi-Robo! Happy Richie Ōsōji!Released: July 23, 2009Developer: Skip Ltd.
- Doki Majo PlusReleased: July 30, 2009Developer: SNK
- Puyo Puyo 7Released: July 30, 2009Developer: Sonic Team
- Saikin Koishiteru?Released: July 30, 2009Developer: MiCROViSion Inc.
- G.I. Joe: The Rise of CobraReleased: August 4, 2009Developer: Double Helix Games
- Bleach DS 4th: Flame BringerReleased: August 6, 2009Developer: Dimps
- Ripened Tingle's Balloon Trip of LoveReleased: August 6, 2009Developer: Vanpool
- Shugo Chara! Norinori! Chara na RhythmReleased: August 6, 2009Platforms: Nintendo DS
- Harvest Moon: Frantic FarmingReleased: August 7, 2009Developer: Winning Entertainment Group
- Brain Age Express: SudokuReleased: August 17, 2009Developer: Nintendo System Development
- Nanashi no Game: MeReleased: August 27, 2009Publisher: Square Enix
- LovePlusReleased: September 3, 2009Developer: Konami
- Pokémon HeartGoldReleased: September 12, 2009Developer: Game Freak
- Pokémon SoulSilverReleased: September 12, 2009Developer: Game Freak
- Art AcademyReleased: September 14, 2009Developer: Kuju Ltd.
- ScribblenautsReleased: September 15, 2009Developer: 5th Cell
- Zuma's Revenge!Released: September 15, 2009Platforms: PlayStation 3, Microsoft Windows, macOS, Nintendo DS, Zeebo, Java Platform, Micro Edition, Windows Phone, Nintendo DSi, Android
- The Idolmaster Dearly StarsReleased: September 17, 2009Developer: Bandai Namco Entertainment
- MySims AgentsReleased: September 25, 2009Developer: Visceral Games, Tose Co.
- Combat of Giants: DragonsReleased: September 29, 2009Developer: Ubisoft Quebec
- Family Feud: 2010 EditionReleased: September 29, 2009Developer: Ludia