- Batman: The Brave and the Bold – The VideogameReleased: September 7, 2010Developer: WayForward Technologies
- NHL SlapshotReleased: September 7, 2010Developer: EA Vancouver
- Schlag den RaabReleased: September 10, 2010Developer: Sproing Interactive Media
- Club Penguin: Game Day!Released: September 16, 2010Developer: Artoon
- Family Party: Fitness FunReleased: September 21, 2010Developer: Tamsoft
- Greg Hastings Paintball 2Released: September 21, 2010Developer: Super X Studios
- Guitar Hero: Warriors of RockReleased: September 24, 2010Developer: Neversoft
- FIFA 11Released: September 28, 2010Developer: EA Vancouver
- Sid Meier's Pirates!Released: September 28, 2010Developer: Firaxis Games
- Sam & Max Beyond Time and SpaceReleased: September 30, 2010Developer: Telltale Games
- MySims SkyHeroesReleased: October 1, 2010Series: MySims
- Def Jam RapstarReleased: October 5, 2010Developer: 4mm Games
- NBA JamReleased: October 5, 2010Developer: EA Vancouver
- Disney Sing It: Family HitsReleased: October 7, 2010Developer: Zoë Mode
- Disney Sing It: Party HitsReleased: October 7, 2010Developer: Zoë Mode
- Sonic the Hedgehog 4: Episode IReleased: October 7, 2010Developer: Sonic Team
- Wii PartyReleased: October 8, 2010Developer: Nintendo Cube
- Just Dance 2Released: October 12, 2010Developer: Ubisoft Paris
- Kirby's Epic YarnReleased: October 14, 2010Developer: Good-Feel
- DJ Hero 2Released: October 19, 2010Developer: Ubisoft Leamington
- Pro Evolution Soccer 2011Released: October 20, 2010Developer: Konami
- Backyard Sports: Rookie RushReleased: October 22, 2010Developer: Humongous Entertainment
- Dora the Explorer: Dora's Big Birthday AdventureReleased: October 26, 2010Developer: High Voltage Software
- Rock Band 3Released: October 26, 2010Developer: Harmonix Music Systems, Backbone Emeryville
- Star Wars: The Force Unleashed IIReleased: October 26, 2010Developer: Lucasfilm Games
- The Sims 3 (Wii)Released: October 26, 2010Developer: Maxis
- Tony Hawk: ShredReleased: October 26, 2010Developer: Robomodo
- WWE SmackDown vs. Raw 2011Released: October 26, 2010Developer: Yuke's
- Deca Sports 3Released: October 28, 2010Developer: Hudson Soft
- CSI: Fatal ConspiracyReleased: October 29, 2010Developer: Telltale Games
- Chevrolet Camaro: Wild RideReleased: October 30, 2010Developer: Visual Impact
- Minute to Win ItReleased: November 2, 2010Developer: Smack Down Productions
- Babysitting MamaReleased: November 5, 2010Developer: Cooking Mama Limited
- Family Feud: DecadesReleased: November 9, 2010Developer: Ludia
- Just Dance KidsReleased: November 9, 2010Developer: Land Ho!
- NBA 2K11Released: November 11, 2010Developer: Visual Concepts
- Sonic ColorsReleased: November 12, 2010Developer: Sonic Team
- Dance Dance RevolutionReleased: November 16, 2010Developer: Konami
- ICarly 2: iJoin the Click!Released: November 16, 2010Developer: Big Blue Bubble
- Marvel Super Hero Squad: The Infinity GauntletReleased: November 16, 2010Developer: Griptonite Games
- Namco Museum MegamixReleased: November 16, 2010Series: Namco Museum
- Harry Potter and the Deathly Hallows – Part 1Released: November 18, 2010Developer: Electronic Arts
- ReloadReleased: November 18, 2010Developer: Mastiff LLC
- Doctor Who: Return to EarthReleased: November 19, 2010Developer: Asylum Entertainment
- Donkey Kong Country ReturnsReleased: November 21, 2010Developer: Retro Studios
- Snowpack ParkReleased: November 22, 2010Developer: Skip Ltd.
- Worms: Battle IslandsReleased: November 22, 2010Developer: Team17
- FlatOutReleased: November 23, 2010Developer: Team6 Game Studios
- Marvel Super Heroes 3D: Grandmaster's ChallengeReleased: November 26, 2010Developer: Neko Entertainment
- Epic MickeyReleased: November 30, 2010Developer: Junction Point Studios
- Karaoke Revolution: GleeReleased: December 2, 2010Developer: Hijinx Studios
- Naruto Shippūden: Gekitō Ninja Taisen! SpecialReleased: December 2, 2010Developer: Eighting
- Taiko no Tatsujin Wii: Minna de Party SandaimeReleased: December 2, 2010Developer: Namco
- Sniper EliteReleased: December 7, 2010Developer: Rebellion Developments
- Need for Speed: Hot PursuitReleased: December 9, 2010Developer: Criterion Games
- Milestone Shooting Collection 2Released: December 30, 2010Developer: Milestone
- Power Rangers SamuraiReleased: 2011Developer: Inti Creates
- Schlag den Raab: Das 2. SpielReleased: 2011Developer: Sproing Interactive Media
- Raving Rabbids: Travel in TimeReleased: January 27, 2011Developer: Ubisoft Paris
- Rock Band: Country Track Pack 2Released: February 2011Developer: Harmonix Music Systems
- Mario Sports MixReleased: February 8, 2011Developer: Square Enix
- You Don't Know JackReleased: February 8, 2011Developer: Jackbox Games
- Rune Factory: Tides of DestinyReleased: February 24, 2011Developer: Neverland
- Bit.Trip FluxReleased: February 25, 2011Developer: Choice Provisions
- Top Spin 4Released: March 15, 2011Publisher: 2K Sports
- WWE All StarsReleased: March 29, 2011Developer: THQ
- Lego Star Wars III: The Clone WarsReleased: March 30, 2011Developer: Traveller's Tales
- Tiger Woods PGA Tour 12Released: April 1, 2011Developer: EA Orlando
- Karaoke Revolution Glee: Volume 2Released: April 5, 2011Developer: Hijinx Studios
- Thor: God of ThunderReleased: April 28, 2011Developer: Liquid Entertainment
- Lego Pirates of the CaribbeanReleased: May 10, 2011Developer: Traveller's Tales
- Virtua Tennis 4Released: May 10, 2011Series: Virtua Tennis
- Chrono TriggerReleased: May 16, 2011Developer: Square
- AFLReleased: May 19, 2011Developer: Wicked Witch Software
- Mystery Case Files: The Malgrave IncidentReleased: June 27, 2011Developer: Big Fish Games
- Wii Play: MotionReleased: June 30, 2011Developer: Skip Ltd., Vanpool, Good-Feel, Nintendo Cube, Prope, Arzest, Chunsoft, Nintendo, Mitchell Corporation
- Harry Potter and the Deathly Hallows – Part 2Released: July 14, 2011Developer: EA Bright Light
- Puyo Puyo!! 20th AnniversaryReleased: July 14, 2011Developer: Sonic Team
- Just Dance 2: Extra SongsReleased: July 19, 2011Developer: Ubisoft Paris
- Monochrome RacingReleased: August 2, 2011Developer: Nordcurrent
- Fishing ResortReleased: August 4, 2011Developer: Prope
- Jerry Rice & Nitus' Dog FootballReleased: August 16, 2011Developer: Judobaby Inc
- Driver: San FranciscoReleased: August 30, 2011Developer: Ubisoft Reflections
- Madden NFL 12Released: August 30, 2011Developer: EA Orlando
- Super Sentai Battle: Ranger CrossReleased: September 9, 2011Developer: Bandai Namco Entertainment
- Dragon Quest 25 Shūnen Kinen Famicom & Super Famicom Dragon Quest I・II・IIIReleased: September 15, 2011Developer: Square Enix
- The Penguins of Madagascar: Dr. Blowhole Returns – Again!Released: September 16, 2011Developer: Griptonite Games
- FIFA 12Released: September 27, 2011Developer: EA Vancouver
- NBA 2K12Released: October 4, 2011Developer: Visual Concepts, Virtuos
- Just Dance 3Released: October 7, 2011Developer: Ubisoft Paris
- Dance Dance Revolution IIReleased: October 11, 2011Developer: Konami
- Go VacationReleased: October 11, 2011Developer: Bandai Namco Entertainment
- Just Dance WiiReleased: October 13, 2011Developer: Ubisoft Milan
- Pro Evolution Soccer 2012Released: October 14, 2011Developer: Konami
- Skylanders: Spyro's AdventureReleased: October 14, 2011Developer: Toys for Bob
- Family Feud: 2012 EditionReleased: October 17, 2011Developer: Ludia
- Kirby's Return to Dream LandReleased: October 24, 2011Developer: HAL Laboratory
- Just Dance Kids 2Released: October 25, 2011Developer: Land Ho!
- Hasbro Family Game Night 4: The Game ShowReleased: November 1, 2011Developer: EA Salt Lake, Wahoo Studios
- Call of Duty: Modern Warfare 3Released: November 8, 2011Developer: Raven Software, Sledgehammer Games, Treyarch, Infinity Ward