- Valhalla Knights: Eldar SagaReleased: October 8, 2009Developer: K2
- Shimano Xtreme FishingReleased: October 9, 2009Developer: EV Interactive
- Cars Race-O-RamaReleased: October 12, 2009Developer: Incinerator Studios
- Drawn to Life: The Next ChapterReleased: October 16, 2009Developer: Planet Moon Studios
- Mario & Sonic at the Olympic Winter GamesReleased: October 16, 2009Developer: Sonic Team, Racjin
- Marvel Super Hero SquadReleased: October 20, 2009Developer: Blue Tongue Entertainment
- Disney Sing It: Pop HitsReleased: October 21, 2009Developer: Zoë Mode
- Pro Evolution Soccer 2010Released: October 23, 2009Developer: Konami
- SpongeBob's Truth or SquareReleased: October 26, 2009Developer: Heavy Iron Studios
- Dance Dance Revolution Hottest Party 3Released: October 27, 2009Developer: Konami
- Doc Louis's Punch-Out!!Released: October 27, 2009Developer: Next Level Games
- ICarlyReleased: October 27, 2009Developer: Blitz Games
- The Magic ObeliskReleased: October 27, 2009Developer: Game Arts
- DJ HeroReleased: October 28, 2009Developer: Ubisoft Leamington
- Sin & Punishment: Star SuccessorReleased: October 29, 2009Developer: Treasure
- Super Robot Wars NEOReleased: October 29, 2009Developer: Banpresto
- Band HeroReleased: November 3, 2009Developer: Neversoft
- Lego Rock BandReleased: November 3, 2009Developer: Harmonix Music Systems, TT Fusion
- Fire Emblem GaidenReleased: November 4, 2009Developer: Intelligent Systems
- Hasbro Family Game Night 2Released: November 5, 2009Developer: EA Bright Light
- Kidz Sports: Crazy Mini Golf 2Released: November 5, 2009Developer: Data Design Interactive
- Jambo! SafariReleased: November 6, 2009Developer: Sega AM2
- Madagascar KartzReleased: November 6, 2009Developer: Sidhe
- Rabbids Go HomeReleased: November 6, 2009Series: Raving Rabbids
- Tales of Monkey Island Chapter 3: Lair of the LeviathanReleased: November 6, 2009Developer: Telltale Games
- Arcade Shooting GalleryReleased: November 9, 2009Developer: CyberPlanet Interactive, CyberPlanet Interactive
- Excitebike: World RallyReleased: November 9, 2009Developer: Monster Games
- NBA 2K10Released: November 9, 2009Developer: Visual Concepts
- Call of Duty: Modern Warfare: Reflex EditionReleased: November 10, 2009Developer: Treyarch
- Hot Wheels Battle Force 5Released: November 10, 2009Developer: Sidhe
- My Baby 2Released: November 11, 2009Developer: Dancing Dots
- CSI: Deadly IntentReleased: November 12, 2009Developer: Telltale Games, Other Ocean
- Harvest Moon: Animal ParadeReleased: November 12, 2009Developer: Marvelous Entertainment
- Tales of Symphonia: Dawn of the New WorldReleased: November 13, 2009Developer: Namco Tales Studio
- F1 2009Released: November 16, 2009Developer: Sumo Digital
- Just DanceReleased: November 17, 2009Developer: Ubisoft Paris
- Naruto Shippūden: Clash of Ninja Revolution 3Released: November 17, 2009Developer: Eighting
- Resident Evil: The Darkside ChroniclesReleased: November 17, 2009Developer: Capcom
- The Princess and the FrogReleased: November 17, 2009Developer: Griptonite Games
- Tony Hawk: RideReleased: November 17, 2009Developer: Robomodo
- A Boy and His BlobReleased: November 19, 2009Developer: WayForward Technologies
- Ghostbusters: The Video GameReleased: November 19, 2009Developer: Red Fly Studio, Terminal Reality
- Taiko no Tatsujin Wii: Do Don to NidaimeReleased: November 19, 2009Developer: Namco
- Pony Friends 2Released: November 20, 2009Developer: Tantalus Media
- Your ShapeReleased: November 24, 2009Platforms: Microsoft Windows, Wii
- Lego Indiana Jones 2: The Adventure ContinuesReleased: November 25, 2009Developer: Traveller's Tales
- Samurai Warriors 3Released: December 3, 2009Developer: Koei Tecmo Holdings
- PokéPark Wii: Pikachu's AdventureReleased: December 5, 2009Developer: Creatures
- Silent Hill: Shattered MemoriesReleased: December 8, 2009Series: Silent Hill
- Tales of GracesReleased: December 10, 2009Developer: Namco Tales Studio
- DiatomicReleased: December 14, 2009Developer: Grendel Games
- Need for Speed: NitroReleased: December 17, 2009Developer: Firebrand Games
- Guitar Hero: Van HalenReleased: December 22, 2009Developer: Neversoft
- Deal or No Deal: Special EditionReleased: 2010Developer: Mad Monkey Studio
- Hasbro Family Game Night 3Released: 2010Developer: EA Bright Light
- WWE SmackDown vs. Raw 2010Released: January 28, 2010Developer: Yuke's
- Toki ToriReleased: January 29, 2010Developer: Two Tribes
- Final Fantasy Crystal Chronicles: The Crystal BearersReleased: February 5, 2010Developer: Square Enix
- Military Madness: NectarisReleased: February 9, 2010Series: Nectaris
- Shiren the WandererReleased: February 9, 2010Developer: Chunsoft
- Super Monkey Ball: Step & RollReleased: February 9, 2010Platforms: Wii
- Karaoke RevolutionReleased: February 12, 2010Developer: Blitz Games
- Diner DashReleased: February 16, 2010Developer: Gamelab
- Tales of Monkey Island Chapter 5: Rise of the Pirate GodReleased: February 19, 2010Developer: Telltale Games
- Endless Ocean 2: Adventures of the DeepReleased: February 22, 2010Developer: Arika
- Sonic & Sega All-Stars RacingReleased: February 23, 2010Developer: Sumo Digital
- Radirgy NoaReleased: February 25, 2010Developer: Milestone
- Mega Man 10Released: March 9, 2010Developer: Inti Creates
- Racket Sports PartyReleased: March 9, 2010Developer: Asobo Studio
- Rugby League 3Released: March 18, 2010Developer: Sidhe
- Scene It? TwilightReleased: March 19, 2010Series: Scene It?
- Red Steel 2Released: March 23, 2010Platforms: Wii
- Dokapon KingdomReleased: March 26, 2010Developer: Sting
- Sakura Wars: So Long, My LoveReleased: March 30, 2010Developer: Idea Factory, Red Entertainment
- All Star KarateReleased: April 20, 2010Developer: Blitz Games
- 2010 FIFA World Cup South AfricaReleased: April 27, 2010Developer: EA Vancouver
- Iron Man 2Released: April 29, 2010Developer: Sega Studios San Francisco
- Prince of Persia: The Forgotten SandsReleased: May 18, 2010Developer: Ubisoft Quebec
- Shrek Forever AfterReleased: May 18, 2010Developer: XPEC Entertainment
- Trauma TeamReleased: May 18, 2010Series: Trauma Center
- WarioWare: D.I.Y. ShowcaseReleased: May 20, 2010Developer: Intelligent Systems, Nintendo Software Planning & Development
- Super Mario Galaxy 2Released: May 23, 2010Developer: Nintendo Entertainment Analysis & Development
- Backyard Sports: Sandlot SluggersReleased: May 25, 2010Developer: HB Studios, Powerhead Games
- No More Heroes 2: Desperate StruggleReleased: May 28, 2010Developer: Grasshopper Manufacture
- Zoo Disc GolfReleased: June 7, 2010Developer: Sonalysts (United States)
- Green Day: Rock BandReleased: June 8, 2010Developer: Harmonix Music Systems
- Xenoblade ChroniclesReleased: June 10, 2010Developer: Monolith Soft Inc.
- Big Beach Sports 2Released: June 18, 2010Developer: Jet Black Games
- Secret Files: TunguskaReleased: June 22, 2010Developer: Animation Arts
- Jett RocketReleased: June 28, 2010Developer: Shin'en Multimedia
- Lego Harry Potter: Years 1–4Released: June 29, 2010Developer: Traveller's Tales
- Tiger Woods PGA Tour 11Released: July 2, 2010Developer: EA Orlando
- Harry Potter and the Half-Blood PrinceReleased: July 3, 2010Developer: Electronic Arts
- Dragon Quest: Monster Battle RoadReleased: July 15, 2010Developer: Eighting
- Madden NFL 11Released: August 10, 2010Developer: EA Orlando
- NHL 2K11Released: August 24, 2010Developer: Visual Concepts
- Twinkle QueenReleased: August 26, 2010Developer: Milestone
- Metroid: Other MReleased: August 31, 2010Developer: D-Rockets, Nintendo Software Planning & Development, Team Ninja
- Paper Wars: Cannon FodderReleased: September 2010Developer: Draw Distance
- Despicable Me: The GameReleased: September 2, 2010Developer: Vicious Cycle Software