- 1943 Kai: Midway KaisenDeveloper: CapcomSeries: 19XX
- 1943: The Battle of MidwayDeveloper: CapcomSeries: 19XX
- 2088Released: 1988Publisher: Zeppelin Games
- Alien MindReleased: 1988Publisher: PBI Software
- Aunt Arctic AdventureReleased: 1988Genre: platform game
- BackgammonReleased: 1988Platforms: Atari ST
- Bakutoushi Patton-KunReleased: 1988Publisher: Soft Pro International
- Ballbreaker IIReleased: 1988Platforms: ZX Spectrum, Amstrad CPC
- Barbarian II: The Dungeon of DraxDeveloper: Palace SoftwareReleased: 1988
- Batman: The Caped CrusaderReleased: 1988Publisher: Ocean Software
- Battle StationsReleased: 1988Platforms: Commodore 64
- Big Challenge! Judo SenshukenReleased: 1988Platforms: Famicom Disk System
- Bob Morane : JungleReleased: 1988Platforms: Thomson TO7, Atari ST
- Bob Morane : OcéansReleased: 1988Platforms: Atari ST, IBM PC compatible, Commodore 64
- Body SlamReleased: 1988Platforms: Intellivision
- Bop'N WrestleReleased: 1988Publisher: Ziggurat Interactive
- BravestarrReleased: 1988Platforms: ZX Spectrum, Amstrad CPC, Commodore 64
- Captain BloodDeveloper: ERE InformatiqueReleased: 1988
- ChimeraReleased: 1988Platforms: Atari ST
- Chrono QuestDeveloper: InfomediaReleased: 1988
- CrackDeveloper: LinelReleased: 1988
- CrillionReleased: 1988Platforms: Commodore 16 and Plus/4, Commodore 64
- Dangerous DaveDeveloper: John RomeroReleased: 1988
- Deep Dungeon III: Yūshi e no TabiDeveloper: Hummingbird SoftSeries: Deep Dungeon
- Digan no MasekiReleased: 1988Platforms: NEC PC-8800 series, NEC PC-9800 series, MSX
- DomeReleased: 1988Platforms: Sharp X1
- DuggerDeveloper: Nightrider Software, LinelReleased: 1988
- Emerald Mine IIDeveloper: Kingsoft GmbHSeries: Emerald Mine
- Exciting Soccer: Konami CupReleased: 1988Platforms: Famicom Disk System
- F-1 Spirit: 3D SpecialSeries: F-1 SpiritReleased: 1988
- F.I.R.E.Released: 1988Platforms: ZX Spectrum
- Family CircuitReleased: 1988Genre: racing video game
- Fighting HawkDeveloper: Taito, Robert I of FranceReleased: 1988
- Fire and ForgetReleased: 1988Platforms: Atari ST
- Fire BamReleased: 1988Platforms: Famicom Disk System
- First ExpeditionReleased: 1988Publisher: Interstel Corporation
- FuggerReleased: 1988Publisher: Bomico Entertainment Software GmbH
- Galactic ProtectorReleased: 1988Genre: shoot 'em up
- GalagaDeveloper: NamcoSeries: Galaxian
- Head Coach v3Released: 1988Platforms: Amstrad PCW, Atari ST, BBC Micro
- In Harm's WayReleased: 1988Publisher: Simulations Canada
- Jet-StoryReleased: 1988Publisher: Ultrasoft
- Joe Blade IIReleased: 1988Platforms: Atari ST, Commodore 64
- Kiki Ippatsu Mayumi-chanDeveloper: SIMS Co., Ltd.Released: 1988
- Lord of WarsDeveloper: SystemSoftReleased: 1988
- Lunar RescueReleased: 1988Platforms: Classic Mac OS
- Manhunter: New YorkDeveloper: EvrywareReleased: 1988
- Microsoft Flight Simulator 3.0Developer: SublogicReleased: 1988
- Might and Magic II: Gates to Another WorldDeveloper: New World ComputingReleased: 1988
- Moon Ball MagicReleased: 1988Platforms: Famicom Disk System
- Mystery of the MummyReleased: 1988Platforms: DOS, Commodore 64
- Nazo no Magazine Disk - Nazoler Land Dai-3 GōSeries: Nazoler LandReleased: 1988
- NeuromancerDeveloper: Interplay EntertainmentReleased: 1988
- Ninja Scooter SimulatorReleased: 1988Platforms: ZX Spectrum, Amstrad CPC, Commodore 64
- Ninja SpiritDeveloper: IremReleased: 1988
- Nobunaga's Ambition IIDeveloper: KoeiReleased: 1988
- Ode to Ramon 1Developer: Team HoiReleased: 1988
- Paha juttuDeveloper: Mikko HyppönenSeries: Paha juttu
- Pool of RadianceDeveloper: Strategic Simulations, Marionette Co., Ltd.Series: Gold Box, Pool of Radiance
- Pro Football SimulatorReleased: 1988Genre: sports video game
- Pro Yakyū Family StadiumReleased: 1988Platforms: NEC PC-8800 series, FM Towns
- Questron IISeries: QuestronReleased: 1988
- Rally BikeDeveloper: ToaplanReleased: 1988
- Rescue MissionReleased: 1988Country of origin: Japan
- RevolterReleased: 1988Platforms: NEC PC-8800 series
- Rocket RangerDeveloper: CinemawareReleased: 1988
- Rupan Sansei - Babylon no ōgon densetsuReleased: 1988Platforms: MSX
- Rychlé šípy 1 - Záhada hlavolamuReleased: 1988Publisher: Ultrasoft
- Samurai SwordReleased: 1988Platforms: Famicom Disk System
- Sengoku MahjongReleased: 1988Genre: mahjong video game
- Sex Vixens from SpaceReleased: 1988Platforms: Commodore 64
- Silviana: Ai Ippai no Little AngelReleased: 1988Platforms: Famicom Disk System, MSX
- SkyChaseDeveloper: MaxisReleased: 1988
- SlaygonReleased: 1988Publisher: Microdeal
- SpeedballDeveloper: The Bitmap BrothersSeries: Speedball
- SplatterhouseDeveloper: NamcoSeries: Splatterhouse
- Star Rank Boxing IIReleased: 1988Platforms: DOS, Apple II, Commodore 64
- Star Saga: One - Beyond the BoundaryReleased: 1988Platforms: Apple IIGS, DOS
- Star VirginReleased: 1988Platforms: MSX
- Starring Charlie ChaplinDeveloper: Canvas SoftwareReleased: 1988
- Steel ThunderDeveloper: AccoladeReleased: 1988
- Street Sports BasketballDeveloper: EpyxReleased: 1988
- Sukeban Janshi RyuukoReleased: 1988Publisher: Sega Interactive
- SyvalionDeveloper: TaitoReleased: 1988
- Tantei Jingūji Saburō: Kiken na FutariSeries: Jake HunterReleased: 1988
- TetrisDeveloper: Atari GamesReleased: 1988
- TetrisReleased: 1988Publisher: Bullet-Proof Software
- The Bard's Tale III: Thief of FateDeveloper: Interplay EntertainmentSeries: The Bard's Tale
- The Fidelity Chessmaster 2100Series: ChessmasterReleased: 1988
- TIT/TNF Mega DemoDeveloper: Team HoiReleased: 1988
- Top LandingDeveloper: TaitoReleased: 1988
- Top RiderReleased: 1988Publisher: Varie
- Toto à la CampagneDeveloper: Epsitec SAReleased: 1988
- Tough TurfReleased: 1988Platforms: arcade video game machine
- Tournament GolfReleased: 1988Platforms: DOS
- Twilight's RansomReleased: 1988Publisher: Paragon Software
- Visions of Aftermath: The BoomtownDeveloper: MindscapeReleased: 1988
- VortexReleased: 1988
- Wall Street WizardReleased: 1988Platforms: DOS, Atari ST
- Warriors of the WastelandDeveloper: Modern ArtsReleased: 1988
- WastelandDeveloper: Interplay EntertainmentReleased: 1988
- Who Framed Roger RabbitReleased: 1988Publisher: Disney Interactive Studios
- Wizardry V: Heart of the MaelstromDeveloper: Sir-TechSeries: Wizardry
- XenonDeveloper: The Bitmap BrothersReleased: 1988
- XZRDeveloper: Telenet JapanSeries: Exile
- XZR IISeries: ExileReleased: 1988
- Yuppi's RevengeDeveloper: AriolasoftReleased: 1988
- ZAVASReleased: 1988Platforms: NEC PC-8800 series
- Captain ComicDeveloper: Michael DenioReleased: January 5, 1988
- TetrisReleased: January 27, 1988Publisher: Spectrum HoloByte, Mirrorsoft
- Kamen Rider Club Gekitotsu ShockerLandDeveloper: Tose Co.Released: February 3, 1988
- AlesteSeries: Power StrikeReleased: February 29, 1988
- Space Harrier 3-DSeries: Space HarrierReleased: February 29, 1988
- Gradius II: Gofer's AmbitionDeveloper: KonamiReleased: March 24, 1988
- Omoikkiri Tanteidan Haadogumi: Matenrou no ChousenjouReleased: March 25, 1988Platforms: Famicom Disk System
- AspicReleased: March 31, 1988Platforms: Famicom Disk System, Sharp X1
- Victory RoadDeveloper: SNKReleased: April 1988
- Famicom Tantei Club: Kieta KōkeishaDeveloper: NintendoSeries: Famicom Detective Club
- Captain TsubasaDeveloper: TecmoReleased: April 28, 1988
- ParodiusDeveloper: KonamiReleased: April 28, 1988
- P-47Developer: NMK, Hamster CorporationSeries: P-47
- Saint Seiya: Ougon Densetsu Kanketsu HenDeveloper: Tose Co.Released: May 30, 1988
- Double DragonDeveloper: Technōs JapanSeries: Double Dragon
- R.B.I. BaseballDeveloper: NamcoSeries: Family Stadium, R.B.I. Baseball
- John Madden FootballSeries: Madden NFLReleased: June 1, 1988
- Football Manager 2Series: Football ManagerReleased: June 17, 1988
- Fire RockReleased: June 20, 1988Platforms: Famicom Disk System
- A-Train IISeries: A-TrainReleased: July 1988
- Galaga '88Developer: NamcoSeries: Galaxian
- Blades of SteelDeveloper: KonamiReleased: July 22, 1988
- The Quest of KiSeries: Babylonian Castle SagaReleased: July 22, 1988
- Radical Bomber!! Jirai-kunReleased: July 29, 1988Platforms: Famicom Disk System
- Super Real BaseballDeveloper: VAP Inc., Pax SoftnicaReleased: July 30, 1988
- Big BangReleased: August 1988Genre: simulation video game
- Cyber TankDeveloper: BanprestoReleased: August 1988
- Eggerland – Revival of the LabyrinthDeveloper: HAL LaboratorySeries: Eggerland
- Bases Loaded II: Second SeasonDeveloper: Tose Co.Released: August 10, 1988
- Eggerland – Departure to CreationDeveloper: HAL LaboratorySeries: Eggerland
- AligatorDeveloper: LMC SoftwareReleased: September 1988
- Bases LoadedDeveloper: Tose Co.Released: September 1988
- King's Quest IVSeries: King's QuestReleased: September 1988
- Super Mario Bros. 2Developer: Nintendo Entertainment Analysis & DevelopmentReleased: September 1988
- Wheel of FortuneDeveloper: Rare Ltd.Series: Wheel of Fortune
- Matou no Houkai: The Hero of BabelDeveloper: Carry LabReleased: September 2, 1988
- Alien CrushSeries: Crush PinballReleased: September 14, 1988
- Haunted CastleDeveloper: KonamiReleased: September 22, 1988
- Zelda II: The Adventure of LinkDeveloper: Nintendo Entertainment Analysis & DevelopmentSeries: The Legend of Zelda
- Leisure Suit Larry Goes Looking for Love (in Several Wrong Places)Series: Leisure Suit LarryReleased: October 1988
- Ninja KazanDeveloper: JalecoReleased: October 1988
- DaisenryakuDeveloper: QuestReleased: October 11, 1988
- Game & Watch: Gold CliffReleased: October 19, 1988Publisher: Nintendo
- Big Challenge! Dogfight SpiritReleased: October 21, 1988Platforms: Famicom Disk System
- Dandy: Zeuon no FukkatsuReleased: October 21, 1988Publisher: Pony Canyon
- Space Harrier IIDeveloper: Sega AM2Series: Space Harrier
- JackDeveloper: Thinking RabbitReleased: November 1988
- Police Quest II: The VengeanceSeries: Police QuestReleased: November 1988
- Tōhō Kenbun RokuDeveloper: Winning Entertainment GroupReleased: November 10, 1988
- Saiyūki WorldDeveloper: NMKReleased: November 11, 1988
- Family Quiz: Four People are RivalsDeveloper: AthenaReleased: November 16, 1988
- Kaijū MonogatariDeveloper: BirthdayReleased: November 18, 1988
- Pachinko GPReleased: November 18, 1988Publisher: Data East
- Family Mahjong II: Shanghai he no MichiDeveloper: NichibutsuReleased: November 25, 1988
- German Tanteidan Maringumi: Zigomar Sousa FileReleased: November 29, 1988Platforms: Famicom Disk System
- Double Dragon II: The RevengeDeveloper: Technōs JapanSeries: Double Dragon
- Psychic WorldDeveloper: Sanritsu DenkiReleased: December 1988
- The Game of RobotSeries: The Game of RobotReleased: December 1988
- Treasure Island DizzyDeveloper: Oliver TwinsSeries: Dizzy
- Momotaro DentetsuDeveloper: Hudson SoftReleased: December 2, 1988
- Nankin no AdventureDeveloper: SunsoftReleased: December 9, 1988
- Ninja GaidenDeveloper: TecmoSeries: Ninja Gaiden
- Vs. ExcitebikeReleased: December 9, 1988Publisher: Nintendo
- '89 Dennou Kyuusei UranaiDeveloper: MicronicsReleased: December 10, 1988
- The TriathronDeveloper: K. Amusement Leasing Co.Released: December 16, 1988
- Final Fantasy IIDeveloper: SquareReleased: December 17, 1988
- Fantasy Zone II: The Tears of Opa-OpaDeveloper: SunsoftReleased: December 20, 1988
- Pro Baseball: Family Stadium '88Developer: NamcoSeries: Family Stadium
- Tarot UranaiDeveloper: Scorpion SoftwareReleased: December 23, 1988