- 21-Two One-Released: 2001Platforms: Microsoft Windows
- 2k InvadersReleased: 2001Platforms: Amstrad CPC
- Adiboo 3Developer: Coktel VisionSeries: Adibou
- Aliens: Thanatos EncounterDeveloper: Crawfish InteractiveSeries: Alien
- All Star Pro-Wrestling IIReleased: 2001Genre: professional wrestling video game
- All-Star Baseball 2002Series: All-Star BaseballReleased: 2001
- Army Men: Green RogueReleased: 2001Genre: action game
- Batta Batta: Kejserens GaveDeveloper: Studio 1-2Released: 2001
- Batta Batta: SkurkestregerDeveloper: Studio 1-2Released: 2001
- Biko 2: Reversible FaceReleased: 2001Platforms: Microsoft Windows
- Blair Witch VolumesDeveloper: Ritual Entertainment, Terminal Reality, Human Head StudiosReleased: 2001
- Bokan GoGoGoReleased: 2001Genre: racing video game
- BulánciDeveloper: SleepTeamReleased: 2001
- Bumper WarsDeveloper: Boston AnimationReleased: 2001
- Cabela's 4x4 Off-Road AdventureReleased: 2001Platforms: Microsoft Windows
- Chee-Chai AlienDeveloper: CreaturesReleased: 2001
- Cross HunterDeveloper: FonfunReleased: 2001
- Dark ElfReleased: 2001Genre: turn-based strategy video game
- Das Geheimnis der Happy Hippo-InselDeveloper: Kritzelkratz 3000 GmbHReleased: 2001
- Deer Hunter 5: Tracking TrophiesDeveloper: Sunstorm InteractiveReleased: 2001
- Des Blood RacingReleased: 2001Platforms: Microsoft Windows
- Di Gi Charat FantasyReleased: 2001Platforms: Microsoft Windows
- Disney's Atlantis: The Lost Empire - The Lost GamesReleased: 2001Publisher: Disney Interactive Studios
- Disney's Tarzan: UntamedDeveloper: Disney Interactive StudiosReleased: 2001
- Driving PartyReleased: 2001Platforms: arcade video game machine
- DT: Lords of GenomesReleased: 2001Platforms: Game Boy, Game Boy Color
- Elite Forces: WWII NormandyDeveloper: 3LV GamesReleased: 2001
- Eve: The Fatal AttractionReleased: 2001Platforms: Microsoft Windows
- Excessive SpeedDeveloper: Legendo Entertainment ABReleased: 2001
- Fighting Legends OnlineReleased: 2001Platforms: Microsoft Windows
- Ford RacingDeveloper: Elite SystemsSeries: Ford Racing
- FortressReleased: 2001Platforms: Microsoft Windows
- FuuraikiReleased: 2001Country of origin: Japan
- Get the Goal!! 4V4Released: 2001Genre: association football video game
- God FieldReleased: 2001Platforms: web browser, Android
- Guilty Gear PetitDeveloper: Arc System WorksSeries: Guilty Gear
- Hajime no Ippo: The TypingReleased: 2001Genre: typing game
- Hard Puncher Hajime no IppoReleased: 2001Platforms: arcade video game machine
- Hired Team: TrialDeveloper: New Media GenerationReleased: 2001
- Hugo: Black Diamond FeverDeveloper: Interactive Television EntertainmentSeries: List of Hugo video games
- Hundred SwordsReleased: 2001Platforms: Microsoft Windows
- Icewind Dale: Heart of WinterDeveloper: Black Isle StudiosSeries: Icewind Dale
- Initial D Second Stage: Taipingu Kantō Saisoku PurojekutoReleased: 2001
- Initial D: Takahashi Ryōsuke no Taipingu Saisoku RironReleased: 2001
- InsaniquariumReleased: 2001Platforms: Microsoft Windows
- Jikkyō Powerful Pro Yakyū 8Released: 2001
- Judgement SilverswordReleased: 2001
- JumpStart SpyMasters: Unmask the PranksterSeries: JumpStart franchiseReleased: 2001
- Kao the KangarooSeries: Kao the KangarooReleased: 2001
- Kaspar i NudådalenDeveloper: Upside StudiosSeries: SVT's Christmas Calendar games
- Keep the Balance!Released: 2001Platforms: Game Boy Color
- Kids Station - Crayon Shin-Chan - Ora to Omoide Tsukuruzo!Released: 2001
- Kids Station: Doraemon: Himitsu no Yojigen PocketReleased: 2001
- Knights of the CrossReleased: 2001Platforms: Microsoft Windows
- Kohan: Immortal SovereignsDeveloper: TimeGate StudiosReleased: 2001
- Lego Creator: Harry PotterDeveloper: Warner Bros. Games, SuperscapeReleased: 2001
- LEGO Island 2: The Brickster's RevengeReleased: 2001Platforms: Game Boy Color
- LEGO Island 2: The Brickster's RevengeReleased: 2001
- Lula's Wet PackDeveloper: Cdv Software EntertainmentSeries: Lula
- Majesty: The Fantasy Kingdom SimDeveloper: Cyberlore StudiosReleased: 2001
- Mata Nui Online GameDeveloper: Templar StudiosReleased: 2001
- Memories Off 2ndSeries: Memories OffReleased: 2001
- Mia's Math Adventure: Just in Time!Developer: Kutoka InteractiveSeries: Mia's Big Adventure Collection
- Mini Car RacingDeveloper: EGamesReleased: 2001
- Momotaro Dentetsu X: Kyushu VersionReleased: 2001
- Mortal Kombat AdvanceSeries: Mortal KombatReleased: 2001
- Mr. Driller 2Developer: NamcoReleased: 2001
- Mumintrollet och den Magiska LampanReleased: 2001Publisher: WSOY
- Namco MuseumSeries: Namco MuseumReleased: 2001
- Neon Genesis Evangelion: Typing Hokan KeikakuReleased: 2001Genre: typing game
- Nobunaga's Ambition: RanseikiDeveloper: Koei Tecmo GamesReleased: 2001
- Nobunaga's Ambition: SoutenrokuDeveloper: Koei Tecmo GamesReleased: 2001
- Oil TycoonReleased: 2001Platforms: Microsoft Windows
- Only You -Re Cross-Developer: AliceSoftReleased: 2001
- Phoenix Wright: Ace AttorneyDeveloper: CapcomReleased: 2001
- Photo BattleDeveloper: NamcoReleased: 2001
- Pixeline: Fuld af fis og balladeDeveloper: Studio 1-2Series: Pixeline
- Planet Hot WheelsDeveloper: MattelReleased: 2001
- Planet of the ApesDeveloper: Visiware, Torus GamesSeries: Planet of the Apes
- Pokémon Party miniReleased: 2001Platforms: Pokémon Mini
- Pokémon Pinball MiniReleased: 2001Platforms: Pokémon Mini
- Pokémon Puzzle CollectionReleased: 2001Platforms: Pokémon Mini
- Pokémon Zany CardsReleased: 2001Platforms: Pokémon Mini
- Professional Baseball Japan 2001Released: 2001
- PutzgrilaReleased: 2001Platforms: personal computer
- REAL ROBOT REGIMENTReleased: 2001Genre: action game
- Real WarReleased: 2001Publisher: Simon & Schuster
- Red Comrades 3: Return of AlaskaDeveloper: Saturn-plusSeries: Red Comrades
- RedCat Groep 4 RekenenDeveloper: Davilex GamesReleased: 2001
- RedCat Groep 4 TaalDeveloper: Davilex GamesReleased: 2001
- RedCat Groep 5 RekenenDeveloper: Davilex GamesReleased: 2001
- RedCat Groep 5 TaalDeveloper: Davilex GamesReleased: 2001
- RedCat Groep 6 RekenenDeveloper: Davilex GamesReleased: 2001
- RedCat Groep 6 TaalDeveloper: Davilex GamesReleased: 2001
- RedCat Groep 7 TaalDeveloper: Davilex GamesReleased: 2001
- RedCat Groep 8 RekenenDeveloper: Davilex GamesReleased: 2001
- RedCat Groep 8 TaalDeveloper: Davilex GamesReleased: 2001
- Reel Fishing: WildSeries: Reel FishingReleased: 2001
- Resident Evil Survivor 2 – Code: VeronicaDeveloper: CapcomReleased: 2001
- Richman 5Released: 2001Platforms: Microsoft Windows
- Robocat Groep 4 RekenenDeveloper: Davilex GamesReleased: 2001
- Rocket Power: Team Rocket RescueReleased: 2001
- Sakura Taisen OnlineReleased: 2001Genre: minigame collection
- Santa Claus JuniorReleased: 2001Platforms: Game Boy Color
- Serious Sam: Gold EditionDeveloper: Croteam, Alligator PitSeries: Serious Sam
- Silent Hill: Play NovelDeveloper: KonamiReleased: 2001
- Simple 1500 Jitsuyou Series Vol. 05: Kusuri no Jiten: Pill Book 2001 Nen BanReleased: 2001Publisher: D3 Publisher
- Simple 1500 Jitsuyou Series Vol. 06: Cocktail no RecipeReleased: 2001Publisher: D3 Publisher
- Simple 1500 Jitsuyou Series Vol. 07: Tanoshiku Manabu Unten MenkyoReleased: 2001Publisher: D3 Publisher
- Simple 1500 Jitsuyou Series Vol. 08: 1-jikan de Wakaru Kabushiki ToushiReleased: 2001Publisher: D3 Publisher
- Simple 1500 Jitsuyou Series Vol. 09: Watashi Style no AromatherapyReleased: 2001Publisher: D3 Publisher
- Simple 1500 Jitsuyou Series Vol. 10: Tarot UranaiReleased: 2001Publisher: D3 Publisher
- Simple 1500 Jitsuyou Series Vol. 11: Katei de Dekiru Tsubo ShiatsuReleased: 2001Publisher: D3 Publisher
- Simple 1500 Jitsuyou Series Vol. 12: Katei no Igaku: Shindan JitenReleased: 2001Publisher: D3 Publisher
- Simple 1500 Series: Hello Kitty Vol. 01: BowlingDeveloper: TamsoftReleased: 2001
- Simple 1500 Series: Hello Kitty Vol. 02: Illust PuzzleDeveloper: TamsoftReleased: 2001
- Simple 1500 Series: Hello Kitty Vol. 03: Block KuzushiDeveloper: TamsoftReleased: 2001
- Simple 1500 Series: Hello Kitty Vol. 04: TrumpDeveloper: Amedio Co., Ltd.Released: 2001
- Ski Jump Challenge 2002Developer: VCC EntertainmentSeries: RTL Ski Jumping
- Skipper & Skeeto: Alphabet GamesDeveloper: Ivanoff InteractiveReleased: 2001
- Skipper & Skeeto: Molly's Music MachineDeveloper: Ivanoff InteractiveReleased: 2001
- Skipper & Skeeto: The Mystery of the Talking SundialDeveloper: Ivanoff InteractiveReleased: 2001
- Skipper & Skeeto: The Number ShopDeveloper: Ivanoff InteractiveReleased: 2001
- SnowcraftReleased: 2001Engine: Adobe Flash
- Star Wraith IISeries: Star WraithReleased: 2001
- Starships Unlimited: Divided GalaxiesReleased: 2001Publisher: Matrix Games, Akella
- State of WarDeveloper: Stefan Pavelka, Emil Popovic, CyproniaSeries: State of War (Game Series)
- Sudden Strike ForeverReleased: 2001Platforms: Microsoft Windows
- Summon Night 2Released: 2001
- Super Collapse!Developer: GameHouseSeries: Collapse!
- Super Monkey BallDeveloper: Amusement VisionReleased: 2001
- Super Robot Battle MailerReleased: 2001Platforms: Microsoft Windows
- Super Robot Wars Compact 2Released: 2001Platforms: WonderSwan
- Superheroes Math ChallengeDeveloper: Ohio Distinctive SoftwareReleased: 2001
- Sword and Fairy InnReleased: 2001Platforms: Microsoft Windows
- Taiko no TatsujinDeveloper: NamcoSeries: Taiko no Tatsujin
- Taiko Risshiden IVReleased: 2001Platforms: Microsoft Windows, PlayStation Portable
- Tanbi Musou Meine LiebeSeries: Meine LiebeReleased: 2001
- Tennis Masters SeriesReleased: 2001Platforms: Microsoft Windows
- The FearReleased: 2001Genre: horror video game
- The Incredible Machine: Even More ContraptionsSeries: The Incredible MachineReleased: 2001
- The NationsDeveloper: JoWooD EntertainmentReleased: 2001
- The Nations: Land of LegendsDeveloper: Neon StudiosReleased: 2001
- The Oregon Trail 4th EditionDeveloper: Minnesota Educational Computing ConsortiumReleased: 2001
- The Powerpuff Girls: Chemical X-TractionDeveloper: VIS EntertainmentReleased: 2001
- The Powerpuff Girls: Mojo Jojo A-Go-GoReleased: 2001Genre: action game
- The Powerpuff Girls: Mojo Jojo's Pet ProjectReleased: 2001Platforms: Microsoft Windows
- This Is Football 2002Series: This Is FootballReleased: 2001
- Three Kingdoms: Fate of the DragonReleased: 2001Publisher: Eidos Interactive
- Tom Clancy's Rainbow Six: Take-Down – Missions in KoreaSeries: Tom Clancy's Rainbow SixReleased: 2001
- Tom Clancy’s Rainbow Six: Rogue Spear – Black ThornSeries: Tom Clancy's Rainbow SixReleased: 2001
- Tomak: Save the Earth - Love StoryReleased: 2001Platforms: Microsoft Windows
- Top Gun: FirestormReleased: 2001Platforms: Game Boy Color
- Train Simulator Real The Yamanote LineSeries: Train Simulator seriesReleased: 2001
- Triple Play BaseballSeries: Triple PlayReleased: 2001
- TropicoSeries: TropicoReleased: 2001
- Vampires Dawn: Reign of BloodSeries: Vampires DawnReleased: 2001
- Virtua Striker 3Series: Virtua StrikerReleased: 2001
- Wild CardReleased: 2001Platforms: WonderSwan
- Xena: Warrior PrincessReleased: 2001Platforms: Game Boy Color
- Yu-Gi-Oh! Dungeon Dice MonstersReleased: 2001Country of origin: Japan
- Yueying ChuanshuoDeveloper: SeasunReleased: 2001
- Zoombinis: Mountain RescueDeveloper: The Learning Company, Technical Education Research CentersSeries: Zoombinis
- Ōma ga TokiReleased: 2001Genre: visual novel
- RuneScapeDeveloper: JagexSeries: RuneScape
- RuneScape ClassicSeries: RuneScapeReleased: January 4, 2001
- ProgearDeveloper: CAVEReleased: January 17, 2001
- Kingdom Under Fire: A War of HeroesDeveloper: PhantagramReleased: January 18, 2001
- Angelic ConcertDeveloper: Kogado StudioReleased: January 19, 2001
- Croc 2Developer: Winning Entertainment GroupReleased: January 23, 2001
- Superchix '76Developer: Driver-Inter, Ltd., Fiendish GamesReleased: January 24, 2001
- Boku DoraemonReleased: January 25, 2001Genre: role-playing video game
- TentamaReleased: January 25, 2001
- Dōsōkai AgainSeries: DōsōkaiReleased: January 26, 2001
- InfantariaDeveloper: CircusReleased: January 26, 2001
- Vampirdzhija VjedogoniaReleased: January 26, 2001Platforms: Microsoft Windows
- Survive in BeijingReleased: February 2001Platforms: Microsoft Windows
- Okaeri! Yuunagi-iro no Koi MonogatariDeveloper: HuneXReleased: February 2, 2001
- ATV Offroad FuryDeveloper: THQSeries: ATV Offroad Fury
- Action Man: Search for Base XDeveloper: Winning Entertainment GroupReleased: February 6, 2001
- Spider-Man: Mysterio's MenaceReleased: February 7, 2001Genre: action game
- Lunatic Dawn TempestSeries: Lunatic DawnReleased: February 8, 2001
- Agent: Special MissionDeveloper: Saturn-plusReleased: February 14, 2001
- Bass Landing 2Developer: Tose Co.Series: Bass Landing
- Punipuni NyūnyūtenDeveloper: AiryuReleased: February 16, 2001
- Clive Barker's UndyingDeveloper: Danger Close GamesReleased: February 21, 2001
- Fear Effect 2: Retro HelixDeveloper: Kronos Digital EntertainmentReleased: February 21, 2001
- Macross M3Released: February 22, 2001Genre: shooter game
- Mary-Kate and Ashley: Winners CircleDeveloper: Tantalus MediaReleased: February 27, 2001
- The Legend of Zelda: Oracle of SeasonsDeveloper: Capcom, FlagshipSeries: The Legend of Zelda
- The Legend of Zelda: Oracle of Seasons and Oracle of AgesDeveloper: Capcom, FlagshipSeries: The Legend of Zelda
- Traffic GiantDeveloper: JoWooD EntertainmentReleased: February 28, 2001
- 3D Pocket PoolReleased: March 2001Platforms: Game Boy Color
- Heath: The Unchosen PathDeveloper: Burut CTReleased: March 2001
- Bloody Roar 3Developer: Hudson Soft, EightingSeries: Bloody Roar
- Zone of the EndersDeveloper: KonamiReleased: March 1, 2001
- Europa UniversalisDeveloper: Paradox Interactive, Development StudioSeries: Europa Universalis
- Sayonara O OshieteReleased: March 2, 2001Publisher: CRAFTWORK
- Conker's Bad Fur DayDeveloper: Rare Ltd.Series: Conker
- Dragon Warrior Monsters 2Developer: Tose Co.Released: March 9, 2001
- Flanker 2.5Developer: Eagle DynamicsReleased: March 9, 2001
- Aidyn Chronicles: The First MageReleased: March 14, 2001Publisher: THQ
- Fallout Tactics: Brotherhood of SteelDeveloper: Micro FortéReleased: March 15, 2001
- From TV Animation - One Piece: Grand Battle!Developer: GanbarionReleased: March 15, 2001
- Pro Evolution SoccerDeveloper: KonamiReleased: March 15, 2001
- Tokyo Xtreme Racer: ZeroDeveloper: GenkiSeries: Tokyo Xtreme Racer
- Doraemon: Kimi to Pet no MonogatariReleased: March 16, 2001Platforms: Game Boy Color
- Mermaid no KisetsuDeveloper: FonfunReleased: March 16, 2001
- Castlevania: Circle of the MoonDeveloper: KonamiReleased: March 21, 2001
- Clay AgentDeveloper: 1C CompanyReleased: March 21, 2001
- EchelonReleased: March 21, 2001Publisher: Buka Entertainment
- F-Zero: Maximum VelocityDeveloper: Nintendo CubeSeries: F-Zero
- Fire Pro WrestlingDeveloper: SpikeSeries: Fire Pro Wrestling
- Mega Man Battle NetworkDeveloper: CapcomSeries: Mega Man Battle Network
- Momotaro FestivalDeveloper: Hudson SoftReleased: March 21, 2001
- Power Pro Kun Pocket 3Developer: KonamiSeries: Power Pro Kun Pocket
- Serious Sam: The First EncounterDeveloper: CroteamSeries: Serious Sam
- Super Mario AdvanceSeries: Super Mario AdvanceReleased: March 21, 2001
- Top Gear GT ChampionshipDeveloper: KemcoSeries: Top Gear
- Klonoa 2: Lunatea's VeilDeveloper: Sony Interactive EntertainmentSeries: Klonoa
- Monster Rancher 3Developer: TecmoSeries: Monster Rancher
- Sakura Wars 3: Is Paris Burning?Developer: Sega Wow, Red EntertainmentSeries: Sakura Wars
- The Simpsons WrestlingDeveloper: Big Ape ProductionsReleased: March 22, 2001
- The SniperReleased: March 22, 2001Publisher: D3 Publisher
- ISS Pro Evolution 2Developer: KonamiReleased: March 23, 2001
- Robot ArenaDeveloper: Gabriel EntertainmentReleased: March 24, 2001
- Black & WhiteDeveloper: Lionhead StudiosSeries: Black & White
- Tech Deck SkateboardingReleased: March 26, 2001Platforms: Game Boy Color
- The Simpsons: Night of the Living Treehouse of HorrorDeveloper: Software CreationsReleased: March 26, 2001
- Dance Dance Revolution 5thMixDeveloper: KonamiSeries: Dance Dance Revolution
- Pokémon Card GB2: Here Comes Team GR!Developer: Hudson SoftSeries: Pokémon video games
- Ganbare Goemon: Ōedo DaikaitenReleased: March 29, 2001Publisher: Konami
- LEGO Island 2: The Brickster's RevengeDeveloper: Silicon Dreams Studios, Crawfish InteractiveReleased: March 30, 2001
- Spy Fox 3: "Operation Ozone"Developer: Humongous EntertainmentSeries: Spy Fox
- Tribes 2Series: TribesReleased: March 30, 2001
- Elitserien 2001Developer: Electronic ArtsReleased: April 2001
- Final Fantasy CollectionDeveloper: SquareSeries: Final Fantasy
- Extreme GhostbustersReleased: April 2, 2001Platforms: Game Boy Color
- Negapoji ~Onii-chan to Yobanaide!!~Developer: Active SoftReleased: April 6, 2001
- Show do milhãoDeveloper: TectoyReleased: April 6, 2001
- Worms World PartyDeveloper: Team17Released: April 6, 2001
- Dr. Mario 64Developer: NintendoReleased: April 8, 2001
- Armored Core 2: Another AgeDeveloper: FromSoftwareSeries: Armored Core
- MizuiroReleased: April 13, 2001Platforms: Microsoft Windows
- Doubutsu no MoriSeries: Animal CrossingReleased: April 14, 2001
- Power Rangers Time ForceDeveloper: Winning Entertainment GroupSeries: Power Rangers
- X-COM: EnforcerDeveloper: MicroProseSeries: X-COM
- Close to: Inori no OkaReleased: April 19, 2001Platforms: Microsoft Windows, PlayStation Portable
- Desperados: Wanted Dead or AliveDeveloper: Spellbound EntertainmentReleased: April 20, 2001
- Lost Memory of Angel FraneDeveloper: Exe-CreateReleased: April 20, 2001
- TropicoDeveloper: PopTop Software, Feral InteractiveSeries: Tropico
- Cossacks: European WarsDeveloper: GSC Game WorldSeries: Cossacks
- Catan – Das KartenspielReleased: April 26, 2001Platforms: Microsoft Windows
- Happy LessonReleased: April 26, 2001Publisher: Datam Polystar
- Love Songs Idol ga ClassmateDeveloper: HuneXReleased: April 26, 2001
- Bomberman TournamentDeveloper: Hudson SoftReleased: April 27, 2001
- Momiji: "Watashi... Ningyō ja Arimasen..."Released: April 27, 2001Platforms: Microsoft Windows
- Mujintō Monogatari X.2001: Sugatanaki AkumaReleased: April 27, 2001Platforms: Microsoft Windows
- Gran Turismo 3: A-SpecDeveloper: Polyphony DigitalReleased: April 28, 2001
- Gauntlet Dark LegacyDeveloper: Atari GamesReleased: May 2001
- Night RaidReleased: May 2001Platforms: ZN-2
- Merchant Prince IIDeveloper: Holistic DesignSeries: Merchant Prince
- Myst III: ExileDeveloper: Presto StudiosSeries: Myst
- B-17 Gunner: Air War Over GermanyDeveloper: Sunstorm InteractiveReleased: May 11, 2001
- Mobile GolfDeveloper: Camelot Software PlanningReleased: May 11, 2001
- The Legend of Zelda: Oracle of AgesDeveloper: Capcom, FlagshipSeries: The Legend of Zelda
- Alone in the Dark: The New NightmareDeveloper: DarkworksSeries: Alone in the Dark
- Exhibition of SpeedDeveloper: Titus InteractiveReleased: May 18, 2001
- The Mission 1937Released: May 18, 2001Platforms: Microsoft Windows
- DoDonPachi IIDeveloper: International Games SystemReleased: May 21, 2001
- Ys Eternal VEReleased: May 23, 2001Publisher: DigiCube
- I-mode mo issyoSeries: Doko Demo IssyoReleased: May 27, 2001
- BejeweledSeries: BejeweledReleased: May 30, 2001
- Spider-Man 2: The Sinister SixDeveloper: Torus GamesReleased: May 30, 2001
- Dinosaur WorldDeveloper: Asylum EntertainmentReleased: June 2001
- Ochiyuku KyōshitsuDeveloper: Atelier KaguyaReleased: June 2001
- Rayman 2Released: June 2001Platforms: Game Boy Color
- Dance Dance Revolution Extra MixDeveloper: KonamiSeries: Dance Dance Revolution
- Hard Truck 2: King of the RoadSeries: Hard TruckReleased: June 7, 2001
- Pinobee: Wings of AdventureDeveloper: ArtoonReleased: June 11, 2001
- Emperor: Battle for DuneDeveloper: Westwood Studios, Intelligent GamesSeries: Dune
- Half-Life: Blue ShiftDeveloper: Gearbox SoftwareReleased: June 12, 2001
- Atlantis: The Lost EmpireReleased: June 14, 2001Platforms: Game Boy Color
- Ame Agari no Neko-tachi eDeveloper: HooksoftReleased: June 15, 2001
- Private NurseDeveloper: AngelSmileReleased: June 15, 2001
- NBA StreetDeveloper: EA VancouverSeries: NBA Street
- Twisted Metal: BlackDeveloper: Incognito EntertainmentSeries: Twisted Metal
- Freddi Fish 5: The Case of the Creature of Coral CoveDeveloper: Humongous EntertainmentSeries: Freddi Fish
- Sonic Adventure 2Developer: Sonic TeamReleased: June 19, 2001
- Legends of Might and MagicDeveloper: New World ComputingReleased: June 20, 2001
- Atelier Lilie: The Alchemist of Salburg 3Series: AtelierReleased: June 21, 2001
- J-League Jikkyō Winning Eleven 2001Developer: KonamiReleased: June 21, 2001
- Tactics Ogre: The Knight of LodisDeveloper: QuestReleased: June 21, 2001
- Diablo II: Lord of DestructionDeveloper: Blizzard NorthSeries: Diablo
- KID MIX SectionReleased: June 28, 2001Genre: digital tabletop game
- Spec Ops: Covert AssaultSeries: Spec OpsReleased: June 28, 2001
- Star Ocean: Blue SphereDeveloper: Tri-AceSeries: Star Ocean
- Final Fantasy ChroniclesDeveloper: Tose Co.Released: June 29, 2001
- Romance of the Three Kingdoms VIIIDeveloper: KoeiSeries: Romance of the Three Kingdoms
- Wacky Races Starring Dastardly and MuttleyReleased: June 29, 2001Genre: racing video game