- Beyond DivinityReleased: 2004Developer: Larian Studios
- Cultures: 8th Wonder of the WorldReleased: 2004Developer: Funatics Software
- Gary Gadget: Building RocketsReleased: 2004Developer: Pipistrello
- Jagged Alliance 2: WildfireReleased: 2004Series: Jagged Alliance
- Pixeline: Hotel SkrottenborgReleased: 2004Developer: Studio 1-2
- Totally Spies!: Swamp Monster BluesReleased: 2004Developer: FiniteMonkey
- WingNuts: Temporal NavigatorReleased: 2004Developer: Freeverse
- Baldur's Gate: Dark Alliance IIReleased: January 20, 2004Developer: Black Isle Studios
- Puyo Pop FeverReleased: February 4, 2004Developer: Sonic Team
- Unreal Tournament 2004Released: March 16, 2004Series: Unreal
- Counter-Strike: Condition Zero Deleted ScenesReleased: March 23, 2004Developer: Gearbox Software, Ritual Entertainment, Valve Corporation
- Syberia IIReleased: March 30, 2004Series: Syberia
- Ricochet Lost WorldsReleased: April 2004Developer: Reflexive Entertainment
- Battlefield 1942Released: June 28, 2004Developer: DICE
- Doom 3Released: August 3, 2004Publisher: Bethesda Softworks, Aspyr, 1C Company
- Crusader KingsReleased: August 27, 2004Developer: Development Studio
- DofusReleased: September 2004Developer: Ankama
- The Sims 2Released: September 16, 2004Developer: Maxis
- Tiger Woods PGA Tour 2005Released: September 20, 2004Developer: EA Sports
- Rome: Total WarReleased: September 22, 2004Developer: Creative Assembly, Feral Interactive
- RollerCoaster Tycoon 3Released: October 26, 2004Developer: Frontier Developments
- The Bard's TaleReleased: October 26, 2004Developer: InXile entertainment
- Jewel QuestReleased: October 29, 2004Platforms: Microsoft Windows, macOS, personal computer
- Bejeweled 2Released: November 5, 2004Series: Bejeweled
- Football Manager 2005Released: November 5, 2004Developer: Sports Interactive
- Zoo Tycoon 2Released: November 9, 2004Developer: Blue Fang Games
- Half-Life 2Released: November 16, 2004Developer: Valve Corporation
- Half-Life: SourceReleased: November 16, 2004Developer: Valve Corporation
- Jets'n'GunsReleased: November 17, 2004Developer: Rake in Grass
- Half-Life 2: DeathmatchReleased: November 30, 2004Developer: Valve Corporation
- CSI: Crime Scene InvestigationReleased: December 6, 2004Developer: Radical Entertainment
- Cave StoryReleased: December 20, 2004Developer: Daisuke Amaya
- Deadly Rooms of Death: King Dugan's DungeonReleased: 2005Platforms: Microsoft Windows, macOS, Linux
- DROD: Journey to Rooted HoldReleased: 2005Platforms: Microsoft Windows, macOS, Linux, IBM PC compatible
- Legion ArenaReleased: 2005Developer: Slitherine Software UK Limited
- Pixeline: StjernestøvReleased: 2005Developer: Krea Medie
- Hearts of Iron IIReleased: January 4, 2005Developer: Development Studio
- Oddworld: Stranger's WrathReleased: January 25, 2005Developer: Oddworld Inhabitants
- Star Wars Knights of the Old Republic II: The Sith LordsReleased: February 8, 2005Developer: Obsidian Entertainment, Aspyr
- DominationReleased: March 3, 2005Developer: Wargaming
- GL-117Released: March 12, 2005Platforms: Microsoft Windows, macOS, Linux
- Geneforge 3Released: March 28, 2005Developer: Spiderweb Software
- Lego Star Wars: The Video GameReleased: March 29, 2005Developer: Traveller's Tales
- Close Combat: First to FightReleased: April 6, 2005Developer: Destineer
- Jade EmpireReleased: April 12, 2005Developer: Bioware
- Postal 2: Apocalypse WeekendReleased: May 12, 2005Developer: Running with Scissors
- FateReleased: May 18, 2005Developer: WildTangent
- LuxorReleased: May 30, 2005Developer: MumboJumbo
- In the GrooveReleased: August 6, 2005Developer: Roxor Games
- Myst V: End of AgesReleased: September 20, 2005Developer: Cyan Worlds
- Rome: Total War: Barbarian InvasionReleased: September 27, 2005Developer: Creative Assembly
- Crazy MachinesReleased: October 2005Developer: Fakt Software
- Age of Empires IIIReleased: October 18, 2005Developer: Robot Entertainment, Glu Mobile, MacSoft Games, Big Huge Games
- Quake 4Released: October 18, 2005Developer: Raven Software
- Football Manager 2006Released: October 21, 2005Developer: Sports Interactive
- Call of Duty 2Released: October 25, 2005Developer: Infinity Ward, Aspyr
- Brothers in Arms: Earned in BloodReleased: October 26, 2005Developer: Gearbox Software
- Half-Life 2: Lost CoastReleased: October 27, 2005Developer: Valve Corporation
- X3: ReunionReleased: October 28, 2005Developer: Egosoft
- En decemberdrömReleased: November 2, 2005Developer: Upside Studios
- Light Rangers: Mending the Maniac MadnessReleased: November 8, 2005Publisher: Digital Praise
- ShadowgroundsReleased: November 11, 2005Developer: Frozenbyte
- Mystery Case Files: HuntsvilleReleased: November 14, 2005Developer: Big Fish Games
- Gamma BrosReleased: 2006Developer: PixelJAM Games
- Diner Dash 2: Restaurant RescueReleased: January 18, 2006Developer: Alawar Entertainment
- PsychonautsReleased: February 10, 2006Developer: Double Fine, Budcat Creations
- Disgaea 2Released: February 23, 2006Developer: Nippon Ichi Software
- Dungeons & Dragons OnlineReleased: February 28, 2006Developer: WB Games Boston
- KeepsakeReleased: March 17, 2006Publisher: The Adventure Company
- Mystery Case Files: Prime SuspectsReleased: April 6, 2006Developer: Big Fish Games
- Black & White 2: Battle of the GodsReleased: April 24, 2006Developer: Lionhead Studios
- Totally Spies!: Zombie Jamboree!Released: May 10, 2006Publisher: Brighter Minds
- Heroes of Might and Magic VReleased: May 16, 2006Developer: Nival
- Kim Possible: Legend of the Monkey’s EyeReleased: May 16, 2006Platforms: Microsoft Windows, macOS
- Half-Life 2: Episode OneReleased: June 2006Developer: Valve Corporation
- WingNuts 2Released: June 2006Developer: Freeverse
- The Movies: Stunts & EffectsReleased: June 6, 2006Developer: Lionhead Studios
- Rome: Total War: AlexanderReleased: June 19, 2006Developer: Creative Assembly, Feral Interactive
- FlatOut 2Released: June 30, 2006Series: FlatOut
- Virtual Villagers: A New HomeReleased: July 18, 2006Developer: Last Day of Work
- Neverwinter Nights: Darkness over DaggerfordReleased: August 16, 2006Developer: Ossian Studios
- Company of HeroesReleased: September 12, 2006Publisher: THQ
- Lego Star Wars II: The Original TrilogyReleased: September 12, 2006Developer: Traveller's Tales
- Dominions 3: The AwakeningReleased: September 29, 2006Developer: Illwinter Game Design
- Championship Manager 2007Released: October 13, 2006Developer: Beautiful Game Studios
- Sid Meier's Railroads!Released: October 17, 2006Developer: Firaxis Games
- Battlefield 2142Released: October 18, 2006Developer: DICE
- Football Manager 2007Released: October 20, 2006Developer: Sports Interactive
- Neverwinter Nights 2Released: October 31, 2006Developer: Obsidian Entertainment
- Medieval II: Total WarReleased: November 11, 2006Developer: Creative Assembly
- Rayman Raving RabbidsReleased: November 19, 2006Engine: Jade
- Geneforge 4: RebellionReleased: November 20, 2006Developer: Spiderweb Software
- Need for Speed: CarbonReleased: December 8, 2006Developer: EA Vancouver
- Mystery Case Files: RavenhearstReleased: December 15, 2006Developer: Big Fish Games
- The Blackwell LegacyReleased: December 23, 2006Developer: Wadjet Eye Games
- AkinatorReleased: 2007Platforms: Microsoft Windows, macOS, BlackBerry, Linux, Windows Phone, web browser, Android
- Petz: Dogz 2Released: 2007Developer: ImaginEngine
- The Half Broken Crown: The Broken KingdomsReleased: 2007Developer: NextGenBooks
- Pixeline i PixielandReleased: January 11, 2007Developer: Krea Medie
- Europa Universalis IIIReleased: January 26, 2007Developer: Development Studio