- Madden NFL 10Released: August 13, 2009Developer: EA Orlando
- WolfensteinReleased: August 18, 2009Developer: Raven Software
- Batman: Arkham AsylumReleased: August 25, 2009Developer: Rocksteady Studios
- Majikoi! Love Me Seriously!Released: August 28, 2009Developer: Minato Soft
- The Beatles: Rock BandReleased: September 9, 2009Developer: Harmonix Music Systems
- Need for Speed: ShiftReleased: September 15, 2009Developer: Slightly Mad Studios
- NHL 10Released: September 15, 2009Developer: EA Vancouver
- NHL 2K10Released: September 15, 2009Developer: Visual Concepts
- Zuma's Revenge!Released: September 15, 2009Platforms: PlayStation 3, Microsoft Windows, macOS, Nintendo DS, Zeebo, Java Platform, Micro Edition, Windows Phone, Nintendo DSi, Android
- Guitar Hero 5Released: September 16, 2009Developer: Neversoft
- Tears to Tiara Gaiden: Avalon no NazoReleased: September 17, 2009Platforms: PlayStation 3, PlayStation Portable
- Ninja Gaiden Sigma 2Released: September 29, 2009Developer: Team Ninja
- FIFA 10Released: October 2009Developer: EA Vancouver
- Dead Space: ExtractionReleased: October 1, 2009Developer: Visceral Games
- NBA Live 10Released: October 6, 2009Developer: EA Vancouver
- Operation Flashpoint: Dragon RisingReleased: October 8, 2009Developer: Codemasters
- Cars Race-O-RamaReleased: October 12, 2009Developer: Incinerator Studios
- Mushroom WarsReleased: October 15, 2009Developer: Creat Studios
- Steins;GateReleased: October 15, 2009Developer: 5pb. Inc.
- BorderlandsReleased: October 20, 2009Developer: Gearbox Software, Feral Interactive
- Disney Sing It: Pop HitsReleased: October 21, 2009Developer: Zoë Mode
- Pro Evolution Soccer 2010Released: October 23, 2009Developer: Konami
- Ratchet & Clank Future: A Crack in TimeReleased: October 27, 2009Developer: Insomniac Games
- DJ HeroReleased: October 28, 2009Developer: Ubisoft Leamington
- BayonettaReleased: October 29, 2009Series: Bayonetta
- Buzz!: Quiz WorldReleased: October 30, 2009Publisher: Sony Interactive Entertainment
- Band HeroReleased: November 3, 2009Developer: Neversoft
- Dragon Age: OriginsReleased: November 3, 2009Developer: Bioware
- Lego Rock BandReleased: November 3, 2009Developer: Harmonix Music Systems, TT Fusion
- Madagascar KartzReleased: November 6, 2009Developer: Sidhe
- NBA 2K10Released: November 9, 2009Developer: Visual Concepts
- Call of Duty: Modern Warfare 2Released: November 10, 2009Developer: Infinity Ward, Aspyr
- Weekly Toro StationReleased: November 11, 2009Developer: Sony Interactive Entertainment
- Tales of Symphonia: Dawn of the New WorldReleased: November 13, 2009Developer: Namco Tales Studio
- Assassin's Creed IIReleased: November 17, 2009Engine: Ubisoft Anvil
- Resident Evil: The Darkside ChroniclesReleased: November 17, 2009Developer: Capcom
- Tony Hawk: RideReleased: November 17, 2009Developer: Robomodo
- NCAA Basketball 10Released: November 18, 2009Developer: EA Vancouver
- Ghostbusters: The Video GameReleased: November 19, 2009Developer: Red Fly Studio, Terminal Reality
- Lego Indiana Jones 2: The Adventure ContinuesReleased: November 25, 2009Developer: Traveller's Tales
- MX vs. ATV ReflexReleased: December 1, 2009Developer: Rainbow Studios
- Samurai Warriors 3Released: December 3, 2009Developer: Koei Tecmo Holdings
- Wizardry: Labyrinth of Lost SoulsReleased: December 9, 2009Developer: Acquire
- Revenge of the Wounded DragonsReleased: December 10, 2009Developer: Wanako Studios
- Tales of GracesReleased: December 10, 2009Developer: Namco Tales Studio
- SodiumReleased: December 17, 2009Series: Sodium
- Guitar Hero: Van HalenReleased: December 22, 2009Developer: Neversoft
- Hasbro Family Game Night 3Released: 2010Developer: EA Bright Light
- Soldner-X 2: Final PrototypeReleased: 2010Publisher: Eastasiasoft
- Tekken 6: Bloodline RebellionReleased: 2010Developer: Bandai Namco Entertainment
- Top GunReleased: 2010Platforms: PlayStation 3, Microsoft Windows, macOS, PlayStation Portable
- DarksidersReleased: January 5, 2010Developer: Vigil Games
- Army of Two: The 40th DayReleased: January 8, 2010Developer: EA Montreal
- Vancouver 2010Released: January 12, 2010Developer: Eurocom
- Mass Effect 2Released: January 26, 2010Developer: Bioware
- Ar Tonelico QogaReleased: January 28, 2010Developer: Gust Co. Ltd.
- WWE SmackDown vs. Raw 2010Released: January 28, 2010Developer: Yuke's
- Toki ToriReleased: January 29, 2010Developer: Two Tribes
- BioShock 2Released: February 9, 2010Developer: 2K Marin
- Military Madness: NectarisReleased: February 9, 2010Series: Nectaris
- Karaoke RevolutionReleased: February 12, 2010Developer: Blitz Games
- Aliens vs. PredatorReleased: February 16, 2010Developer: Rebellion Developments
- Deadly PremonitionReleased: February 23, 2010Developer: Access Games
- Sonic & Sega All-Stars RacingReleased: February 23, 2010Developer: Sumo Digital
- The TerminatorReleased: February 25, 2010Publisher: Big Head Games
- MLB 10: The ShowReleased: March 2, 2010Developer: San Diego Studio
- Racket Sports PartyReleased: March 9, 2010Developer: Asobo Studio
- Dragon Age: Origins – Return to OstagarReleased: March 11, 2010Developer: Bioware
- Dragon Age: Origins – AwakeningReleased: March 16, 2010Developer: Bioware
- God of War IIIReleased: March 16, 2010Developer: Santa Monica Studio
- MotoGP 09/10Released: March 16, 2010Series: MotoGP
- Yakuza 4Released: March 18, 2010Series: Yakuza
- Just Cause 2Released: March 23, 2010Developer: Avalanche Studios Group
- Shooter: Space ShotReleased: March 24, 2010Publisher: D3 Publisher, Agetec
- Fist of the North Star: Ken's RageReleased: March 25, 2010Developer: Tecmo
- Dead to Rights: RetributionReleased: April 1, 2010Developer: Volatile Games
- Sam & Max: The Devil's PlayhouseReleased: April 2, 2010Developer: Telltale Games
- Final Fight: Double ImpactReleased: April 15, 2010Developer: Proper Games
- NieRReleased: April 22, 2010Developer: Cavia
- NieR ReplicantReleased: April 22, 2010Developer: Cavia
- 2010 FIFA World Cup South AfricaReleased: April 27, 2010Developer: EA Vancouver
- NieR GestaltReleased: April 27, 2010Developer: Cavia
- Super Street Fighter IVReleased: April 27, 2010Developer: Dimps
- Iron Man 2Released: April 29, 2010Developer: Sega Studios San Francisco
- Metal Gear Solid: Peace WalkerReleased: April 29, 2010Series: Metal Gear
- Lost Planet 2Released: May 11, 2010Developer: Capcom
- Skate 3Released: May 11, 2010Series: Skate
- Prince of Persia: The Forgotten SandsReleased: May 18, 2010Engine: Ubisoft Anvil
- Shrek Forever AfterReleased: May 18, 2010Developer: XPEC Entertainment
- Green Day: Rock BandReleased: June 8, 2010Developer: Harmonix Music Systems
- Atelier Totori: The Adventurer of ArlandReleased: June 24, 2010Developer: Gust Co. Ltd.
- Moujuutsukai to Ouji-samaReleased: June 24, 2010Developer: Otomate, Design Factory
- SingularityReleased: June 25, 2010Developer: Raven Software
- Lego Harry Potter: Years 1–4Released: June 29, 2010Developer: Traveller's Tales
- Sniper: Ghost WarriorReleased: June 29, 2010Developer: CI Games S.A.
- Tiger Woods PGA Tour 11Released: July 2, 2010Developer: EA Orlando
- Harry Potter and the Half-Blood PrinceReleased: July 3, 2010Developer: Electronic Arts
- White Knight Chronicles IIReleased: July 8, 2010Developer: Level-5
- Blacklight: Tango DownReleased: July 14, 2010Developer: Zombie Studios
- The King of Fighters XIIIReleased: July 14, 2010Developer: SNK