- Age of Empires II Deluxe MobileReleased: 2006
- Aliens: ExterminationDeveloper: Play MechanixReleased: 2006
- Asphalt 3: Street RulesDeveloper: GameloftSeries: Asphalt
- Athena: Full ThrottleDeveloper: SNKReleased: 2006
- Battle B-DamanReleased: 2006Country of origin: Japan
- Bleach: Hanatareshi YabouReleased: 2006Country of origin: Japan
- Bonk's ReturnDeveloper: Two TribesSeries: Bonk
- BoundishSeries: Bit GenerationsReleased: 2006
- C-evoReleased: 2006Platforms: Microsoft Windows
- Championsheep RallyDeveloper: Black Sheep StudioReleased: 2006
- Commandos: Strike ForceDeveloper: Pyro StudiosSeries: Commandos
- Cossacks II: Battle for EuropeDeveloper: GSC Game WorldSeries: Cossacks
- Crazy Chicken: Heart of TibetDeveloper: Sproing Interactive MediaReleased: 2006
- Crazy Chicken: PiratesDeveloper: Sproing Interactive MediaReleased: 2006
- Da Capo IISeries: Da CapoReleased: 2006
- Dear PianissimoDeveloper: Kogado StudioReleased: 2006
- Die Höhenwelt Saga – Das Magie KartenspielDeveloper: WeltenschmiedeReleased: 2006
- Disney's American Dragon: Jake Long - Rise of the Huntsclan!Released: 2006Genre: action game
- DogzDeveloper: ImaginEngineSeries: Petz
- DotstreamSeries: Bit GenerationsReleased: 2006
- Driver: VegasDeveloper: GameloftReleased: 2006
- Etrom: The Astral EssenceReleased: 2006Publisher: Softclub
- Finding Forever EdenReleased: 2006Engine: RPG Maker 2003
- Fire Department 3Series: Fire DepartmentReleased: 2006
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- Gamma BrosDeveloper: PixelJAM GamesReleased: 2006
- GhostbustersReleased: 2006Platforms: mobile phone
- Gormiti: The Masters of Gorm IslandDeveloper: Engine SoftwareReleased: 2006
- Gran Turismo 4 Online Test VersionDeveloper: Polyphony DigitalReleased: 2006
- Hannah MontanaReleased: 2006Platforms: Nintendo DS
- HorsezDeveloper: MTOSeries: Petz
- IHRA Drag Racing: Sportsman EditionSeries: IHRA Drag RacingReleased: 2006
- Ina☆Koi! ~Oinari-sama to Motemote no Tatari~Developer: WhirlpoolReleased: 2006
- Iron ChefReleased: 2006Publisher: Phoenix Games B.V.
- Jikkyō Powerful Major LeagueReleased: 2006Publisher: Konami
- King's Quest IIIDeveloper: Infamous AdventuresReleased: 2006
- Magic Ball 3Developer: Dream Dale, Alawar EntertainmentSeries: Magic Ball
- Magnus & Myggen: Jeg Vil LæseDeveloper: Ivanoff InteractiveReleased: 2006
- Massive Assault Network 2Released: 2006Publisher: Wargaming
- Metal Gear Solid: Digital Graphic NovelSeries: Metal GearReleased: 2006
- Mumin och de Mystiska VrålenReleased: 2006Platforms: Microsoft Windows, Nintendo DS
- My Pet HotelDeveloper: Independent Arts SoftwareSeries: Imagine
- Myth Makers: Super Kart GPDeveloper: Data Design InteractiveReleased: 2006
- Naruto: Ninja DestinyReleased: 2006Platforms: Nintendo DS
- NBA 2K7Developer: Visual ConceptsSeries: NBA 2K
- Nuclear Titbit 2Developer: VZ.labReleased: 2006
- Pippa Funnell: The Golden Stirrup ChallengeReleased: 2006Platforms: Microsoft Windows
- Pirates: Legend of the Black BuccaneerDeveloper: WideScreen GamesReleased: 2006
- Really? Really!Developer: NavelReleased: 2006
- Riviera: The Promised LandDeveloper: StingSeries: Dept. Heaven
- Rockman EXE Legend of NetworkDeveloper: CapcomSeries: Mega Man Battle Network
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- Ryu-KokuReleased: 2006Platforms: Microsoft Windows, PlayStation Portable
- Saints RowDeveloper: Mnemonic StudiosReleased: 2006
- Sam & Max: Culture ShockDeveloper: Telltale GamesReleased: 2006
- Sexy Beach 3Released: 2006Platforms: Microsoft Windows
- Slash'EMReleased: 2006Platforms: Microsoft Windows, Linux
- SouptoysReleased: 2006Publisher: Oberon Media
- Space Empires VDeveloper: Malfador MachinationsSeries: Space Empires
- Super Collapse! 3Developer: GameHouseSeries: Collapse!
- The BlobDeveloper: Concept by Utrecht School of the ArtsReleased: 2006
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- The MarkReleased: 2006Publisher: Akella, JoWooD Entertainment
- The Operational Art of War IIISeries: The Operational Art of WarReleased: 2006
- The Ship SingleplayerDeveloper: OuterlightReleased: 2006
- Tomb Raider: LegendDeveloper: HumanSoftSeries: Tomb Raider
- Tomb Raider: LegendDeveloper: HumanSoftSeries: Tomb Raider
- Tony Tough 2: A Rake's ProgressDeveloper: Stefano GualeniSeries: Tony Tough
- Top GunReleased: 2006Platforms: Nintendo DS
- TrackMania NationsDeveloper: NadeoSeries: TrackMania
- WestwardDeveloper: Sandlot GamesReleased: 2006
- Whirlwind over VietnamReleased: 2006Publisher: Evolved Games
- Who Wants To Be A Millionaire: Family Entertainment EditionDeveloper: Zoo Digital (United Kingdom)Released: 2006
- Wings 2Released: 2006Platforms: Linux
- Winter SportsReleased: 2006Publisher: Oxygen Games
- WolfschanzeReleased: 2006
- Yoomurjak's RingDeveloper: PierrotReleased: 2006
- Ys V: Lost Kefin, Kingdom of SandDeveloper: AccessReleased: 2006
- Taito Memories PocketSeries: Taito MemoriesReleased: January 5, 2006
- Kidz Sports BasketballDeveloper: Data Design InteractiveSeries: Kidz Sports
- Mega Man X CollectionDeveloper: CapcomSeries: Mega Man X
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- Snowy: Treasure Hunter 2Developer: Aliasworlds EntertainmentReleased: January 13, 2006
- 25 to LifeDeveloper: Avalanche SoftwareReleased: January 17, 2006
- Diner Dash 2: Restaurant RescueDeveloper: Alawar EntertainmentReleased: January 18, 2006
- Iron FeatherDeveloper: KonamiReleased: January 19, 2006
- Gore Screaming ShowReleased: January 20, 2006Publisher: JAST USA
- Torino 2006Released: January 24, 2006Publisher: 2K Sports
- Ar Tonelico: Melody of ElemiaDeveloper: Gust Co. Ltd.Released: January 26, 2006
- Bleach: The Blade of FateDeveloper: TreasureReleased: January 26, 2006
- Dirge of Cerberus: Final Fantasy VIIDeveloper: Square EnixSeries: Compilation of Final Fantasy VII
- English Training: Have Fun Improving Your Skills!Developer: Nintendo Software Planning & DevelopmentReleased: January 26, 2006
- Onimusha: Dawn of DreamsDeveloper: CapcomReleased: January 26, 2006
- Evil Islands: Lost in AstralReleased: January 27, 2006Publisher: Nival
- Futari de Hitotsu no KoigokoroReleased: January 27, 2006Platforms: Microsoft Windows
- Maid-san★Spirits! ~Watashi no Naka ni Iru Anata~Released: January 27, 2006Platforms: Microsoft Windows
- Pilot Brothers: The Atlantic Herring MysteryDeveloper: Pipe studioReleased: January 27, 2006
- Days of Memories 2: Boku no Ichiban Taisetsu na Kimi eReleased: February 2006Country of origin: Japan
- Pump It Up ZeroSeries: Pump It UpReleased: February 1, 2006
- Heroes of Malgrimia: The Lost World of MagicReleased: February 2, 2006Publisher: Noviy Disk
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- HimemikoSeries: HimemikoReleased: February 3, 2006
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- Age of Empires: The Age of KingsReleased: February 14, 2006Publisher: Majesco Entertainment
- Empire Earth II: The Art of SupremacyDeveloper: Rockstar New EnglandSeries: Empire Earth
- Midway Arcade Treasures Deluxe EditionDeveloper: Midway GamesSeries: Midway Arcade Treasures
- Nicktoons Winners Cup RacingReleased: February 15, 2006Publisher: Cosmi Corporation
- Dance Dance Revolution StrikeDeveloper: KonamiSeries: Dance Dance Revolution
- Monster Hunter 2Developer: CapcomReleased: February 16, 2006
- Fight Night Round 3Developer: Electronic Arts ChicagoSeries: Fight Night
- Initial D: Street StageReleased: February 20, 2006Platforms: PlayStation Portable
- Galactic Civilizations II: Dread LordsDeveloper: StardockSeries: Galactic Civilizations
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- Disgaea 2Developer: Nippon Ichi SoftwareSeries: Disgaea
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- Namco Museum Vol.2Developer: Tose Co., Gotch Technology Corp.Series: Namco Museum
- Naval Ops: Warship Gunner 2Developer: KoeiReleased: February 23, 2006
- Separate HeartsReleased: February 23, 2006Genre: visual novel
- Suikoden VDeveloper: KonamiSeries: Suikoden
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- Boy Meets GirlDeveloper: Front WingReleased: February 24, 2006
- Metal Slug 6Developer: SNKSeries: Metal Slug
- Muv-Luv AlternativeDeveloper: ÂgeSeries: Muv-Luv
- MX vs. ATV: On the EdgeDeveloper: Rainbow StudiosSeries: MX vs. ATV
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- Dungeons & Dragons OnlineDeveloper: WB Games BostonReleased: February 28, 2006
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- MLB 06: The ShowDeveloper: San Diego StudioSeries: MLB: The Show
- SWAT ForceSeries: SWATReleased: February 28, 2006
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- Children of ManaDeveloper: Square EnixSeries: Mana
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- Maximum-FootballReleased: March 3, 2006Publisher: Matrix Games
- Tales of Eternia OnlineDeveloper: NamcoSeries: Tales
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- The Legend of Heroes: Trails in the Sky SCReleased: March 9, 2006Publisher: Ghostlight, Xseed Games
- Tom Clancy's Ghost Recon Advanced WarfighterDeveloper: Ubisoft ParisReleased: March 9, 2006
- Heracles: Battle with the GodsDeveloper: Neko EntertainmentReleased: March 10, 2006
- DaxterDeveloper: Ready at DawnSeries: Jak and Daxter
- Driver: Parallel LinesDeveloper: Ubisoft ReflectionsReleased: March 14, 2006
- Neopets: Petpet Adventures: The Wand of WishingDeveloper: Santa Monica StudioReleased: March 14, 2006
- Beatmania IIDX 13: DistortedDeveloper: KonamiSeries: Beatmania IIDX
- Final Fantasy XIIDeveloper: Square EnixReleased: March 16, 2006
- Keroro Gunso: Enshū da Yo! Zenin ShūgōDeveloper: BandaiReleased: March 16, 2006
- Buzz!: The BIG QuizReleased: March 17, 2006Publisher: Sony Interactive Entertainment
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- KeepsakeReleased: March 17, 2006Publisher: The Adventure Company
- Romance of the Three Kingdoms XIDeveloper: KoeiSeries: Romance of the Three Kingdoms
- SeafightDeveloper: Bigpoint GmbHReleased: March 18, 2006
- Refuse: Home Sweep HomeReleased: March 20, 2006Platforms: Microsoft Windows
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- CMT Presents: Karaoke Revolution CountryDeveloper: Harmonix Music SystemsReleased: March 21, 2006
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- The GodfatherDeveloper: Visceral GamesReleased: March 21, 2006
- Tom Clancy's Splinter Cell: EssentialsSeries: Tom Clancy's Splinter CellReleased: March 21, 2006
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- Ace Combat Zero: The Belkan WarDeveloper: NamcoSeries: Ace Combat
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- Dynasty Warriors Vol. 2Developer: Koei Tecmo HoldingsSeries: Dynasty Warriors
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- Lost ChildReleased: March 24, 2006Platforms: Microsoft Windows
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- SetsueiReleased: March 24, 2006Publisher: Silver Bullet
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- Animal Crossing: Wild WorldDeveloper: Nintendo Entertainment Analysis & DevelopmentSeries: Animal Crossing
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- Mother 3Developer: HAL LaboratoryReleased: April 20, 2006
- SpellForce 2: Shadow WarsDeveloper: EA PhenomicReleased: April 20, 2006
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- Totally Spies!: Zombie Jamboree!Released: May 10, 2006Publisher: Brighter Minds
- Eureka Seven Vol. 2: The New VisionDeveloper: BandaiReleased: May 11, 2006
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- Heroes of Might and Magic VDeveloper: NivalSeries: Heroes of Might and Magic
- Kim Possible: Legend of the Monkey’s EyeReleased: May 16, 2006Platforms: Microsoft Windows, macOS
- Beatmania IIDX 11 IIDXREDDeveloper: KonamiSeries: Beatmania IIDX
- JuicedDeveloper: THQ Digital Studios UKReleased: May 18, 2006
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- Devil May Cry 3: Special EditionReleased: May 23, 2006Platforms: Microsoft Windows
- Metroid Prime HuntersDeveloper: Nintendo Software TechnologyReleased: May 23, 2006
- Rogue TrooperDeveloper: Rebellion DevelopmentsReleased: May 23, 2006
- Dragon Quest & Final Fantasy in Itadaki Street PortableDeveloper: Think GarageReleased: May 25, 2006
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- WingNuts 2Developer: FreeverseReleased: June 2006
- The Movies: Stunts & EffectsDeveloper: Lionhead StudiosReleased: June 6, 2006
- MotoGP '06Developer: Black Rock StudioSeries: MotoGP
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- DarkStar OneDeveloper: AscaronReleased: June 16, 2006
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- FlatOut 2Series: FlatOutReleased: June 30, 2006
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- Persona 3Series: PersonaReleased: July 13, 2006
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