| Sony | Japan | April 2021 | — | 1 |
| Sony Computer Entertainment America | United States | — | 1 | 6 |
| Sony Group | Japan | May 7, 1946 | 1 | 3 |
| Sony Imagesoft | United States | 1989 | — | — |
| Sony Interactive Entertainment | United States | April 2016 | 31 | 349 |
| Sony Interactive Studios America | United States | 1995 | 3 | — |
| Sony Music Entertainment Japan | Japan | March 11, 1968 | — | 3 |
| Sony Network Communications Inc. | Japan | November 1995 | — | 1 |
| Sony Pictures Digital | United States | 1997 | — | 1 |
| Sonzai Games | Japan | — | 1 | — |
| Sora Ltd. | Japan | 2005 | 5 | — |
| SORAYUME | Japan | September 21, 2005 | 1 | 1 |
| SoulGame Studio | France | December 16, 2019 | 4 | — |
| Southend Interactive | Sweden | — | 1 | — |
| SouthPeak Games | United States | 1996 | — | 7 |
| Space Lizard Studio | United Kingdom | — | 2 | 1 |
| Spark Unlimited | United States | 2002 | 2 | — |
| Sparkling Society | — | 2013 | 1 | 1 |
| Sparkypants Studios | United States | 2011 | 1 | — |
| Spearhead Games | Canada | 2012 | 1 | 1 |
| Specialbit | Ukraine | October 25, 2006 | 2 | 2 |
| Spectrum HoloByte | United States | 1983 | 2 | 5 |
| Spellbound Entertainment | Germany | 1994 | 8 | — |
| Spiderweb Software | United States | 1994 | 19 | 19 |
| Spike | Japan | 2005 | 15 | 16 |
| Spike Chunsoft | Japan | 2012 | 21 | 27 |
| Spil Games | Netherlands | 2001 | — | 1 |
| Spiral Circus | United Kingdom | October 23, 2018 | 1 | — |
| Spiral House | United Kingdom | 1998 | 1 | — |
| Spiral Up Games | Singapore | 2021 | — | 1 |
| Splash Damage | United Kingdom | April 30, 2001 | 6 | — |
| Spokko | Poland | — | 1 | — |
| Spooky Doorway | Ireland | — | 1 | — |
| Sports Interactive | United Kingdom | July 21, 1994 | 33 | — |
| Sports Mogul | United States | 1997 | — | — |
| Sporty Peppers | France | April 16, 2021 | 1 | 1 |
| Sprakelsoft | Germany | — | 3 | 3 |
| Springfish Co., Ltd. | Taiwan | October 24, 2018 | — | 1 |
| Springloaded | Singapore | — | 1 | — |
| Sproing Interactive Media | Austria | 2001 | 20 | 1 |
| Spry Fox | United States | 2010 | 3 | 2 |
| Square | Japan | September 1986 | 39 | 42 |
| Square Enix | Japan | 1975 | 107 | 243 |
| Square Enix Business Division 1 | Japan | December 2013 | 1 | — |
| Square Enix Montréal | — | 2011 | 2 | — |
| Squiddershins | United States | — | 2 | 1 |
| St.GIGA | Japan | 1990 | — | 3 |
| Stage Clear Studios | Spain | 2012 | 3 | — |
| Stainless Games | United Kingdom | 1993 | 5 | 3 |
| Stainless Steel Studios | United States | 1997 | 2 | — |
| Star Drifters | Poland | — | 2 | 2 |
| Starbreeze Studios | Sweden | 1998 | 5 | 5 |
| Starbyte | Germany | 1988 | 2 | 4 |
| Stardock | United States | 1991 | 14 | 12 |
| STARFISH-SD | Japan | 1994 | 1 | 3 |
| Starward Industries | Poland | 2018 | 1 | — |
| Starz Entertainment | United States | April 28, 1997 | — | 2 |
| State of Play | United Kingdom | 2008 | 5 | 5 |
| Steckenpferd Enterprises UG | Germany | — | — | 1 |
| Steel Mantis | United States | — | 1 | — |
| Steel Monkeys | — | 1998 | 2 | — |
| Stegosoft Games | United States | November 14, 2013 | 1 | — |
| Stellar Stone | United States | 2000 | 1 | — |
| Step Creative Group | United States | 1994 | 1 | — |
| Stern Electronics | United States | 1977 | 1 | 1 |
| Stillalive studios | Austria | 2010 | 6 | — |
| Sting | Japan | February 7, 1989 | 17 | 4 |
| Stone Lantern Games | United States | — | 1 | — |
| Stormfront Studios | United States | 1989 | 7 | — |
| Stormind Games | Italy | — | 2 | — |
| Stormling Studios | Turkey | — | 1 | — |
| StormRegion | — | 1997 | 2 | — |
| Straight Edge | Japan | April 2016 | — | — |
| Straka.studio | Slovakia | — | 1 | 1 |
| Strange Scaffold | United States | February 12, 2019 | 5 | 4 |
| Strategic Simulations | United States | 1979 | 15 | 28 |
| Strategy First | United Kingdom | 1988 | 4 | 39 |
| Stray Bombay | United States | — | 1 | 1 |
| Stray Fawn Studio | Switzerland | — | 2 | 2 |
| Stray Kite Studios | United States | — | 1 | — |
| Streum On Studio | — | August 2, 2007 | 1 | — |
| Striking Distance Studios | United States | 2019 | 1 | — |
| Studio 1-2 | Denmark | — | 12 | 1 |
| Studio 100 | Belgium | March 29, 1996 | — | 1 |
| Studio 33 | United Kingdom | 1998 | 3 | — |
| Studio Bside | South Korea | July 2017 | 1 | 1 |
| Studio Chien d'or | Canada | — | — | 1 |
| Studio Cypix | South Africa | — | 1 | 1 |
| Studio Drydock | Australia | — | 1 | 1 |
| Studio e.go! | Japan | 1998 | 14 | 10 |
| Studio Fizbin | Germany | 2011 | 4 | — |
| Studio Gamaii | Canada | — | 1 | 1 |
| Studio Huckepack | Germany | — | 1 | — |
| Studio Inkyfox UG | — | — | 1 | — |
| Studio Line | Japan | August 1997 | 1 | — |
| Studio Mebius | Japan | — | 2 | 2 |
| Studio Nue | Japan | 1972 | — | — |
| Studio Pango | France | 2012 | 1 | 1 |
| Studio Ryokucha | Japan | 2001 | 1 | 1 |
| Studio Saizensen | Japan | — | 7 | — |