| S2 Games | United States | 2003 | 1 | 1 |
| Sabec Limited | United Kingdom | 1993 | 2 | 1 |
| Saber Interactive | United States | 2001 | 8 | 8 |
| Saber Interactive Porto | Portugal | 2008 | 2 | 1 |
| Sacnoth | Japan | April 30, 1997 | 4 | — |
| Sad Panda Studios | Canada | 2015 | 1 | 1 |
| Safari Games | Japan | — | 2 | — |
| Saffire | United States | 1993 | 3 | — |
| Saga Planets | Japan | — | 5 | 4 |
| Sakari Games | Belgium | — | 3 | 3 |
| Sakata SAS Co., Ltd. | Japan | 1985 | 2 | — |
| SakeVisual | United States | 2009 | 4 | 3 |
| SakuraGame | People's Republic of China | — | — | 6 |
| Sammy Corporation | Japan | November 1975 | — | 12 |
| Samsung Electronics | South Korea | January 13, 1969 | — | 2 |
| Samurai Punk | Australia | — | 3 | 2 |
| San Diego Studio | United States | 2001 | 20 | — |
| Sand Castles Studio | Spain | November 2019 | 1 | — |
| Sandlot | Japan | March 12, 2001 | 7 | — |
| Sandlot Games | United States | 2002 | 5 | 4 |
| Sanrio | Japan | August 10, 1960 | 2 | — |
| Sanritsu Denki | Japan | — | 2 | — |
| Santa Entertainment | Japan | 1997 | 1 | — |
| Santa Monica Studio | United States | 1999 | 5 | — |
| Santa Ragione | Italy | June 21, 2010 | 1 | 2 |
| Sanuk Games | Thailand | 2003 | 6 | — |
| Sanyo | Japan | February 1947 | 1 | — |
| Sanzaru Games | United States | 2007 | 12 | — |
| Saona Studios | Spain | — | 1 | — |
| Sapphire Dragon Productions | Australia | — | 3 | 3 |
| Sarbakan | Canada | 1998 | 1 | — |
| Sassybot | Netherlands | — | 1 | 1 |
| SAT-BOX | Japan | — | 3 | 3 |
| Saturn-plus | — | 1997 | 12 | — |
| Savage Entertainment | United States | 1997 | 1 | — |
| Scavengers Studio | Canada | — | 1 | 1 |
| SCE Studio Liverpool | United Kingdom | 1984 | 13 | 16 |
| Schell Games | United States | 2002 | 8 | 7 |
| Schmidt Spiele | Germany | 1907 | — | — |
| Scholastic Corporation | United States | 1920 | 1 | 2 |
| Scitron & Art Inc. | Japan | 1988 | 2 | — |
| Scopely | United States | 2011 | 1 | — |
| Screenlife Games | United States | 2002 | 1 | 1 |
| Scriptwelder Studio | Poland | — | 14 | 1 |
| SCS Software | Czech Republic | 1997 | 18 | 4 |
| Sculptured Software | United States | 1984 | 7 | — |
| Scythe Dev Team | United States | 2017 | 1 | — |
| SeaCorpTech | United Kingdom | — | 1 | 1 |
| Seasun | People's Republic of China | 1995 | 4 | 3 |
| Seaven Studio | France | February 25, 2013 | 1 | 2 |
| Second Dinner | United States | April 2018 | 1 | — |
| Second Maze | Netherlands | — | — | 2 |
| Secret Mode | United Kingdom | September 29, 2020 | — | 7 |
| Sega AM2 | Japan | October 1983 | 31 | — |
| Sega Amusement | Japan | November 26, 1971 | 1 | — |
| SEGA Europe | United Kingdom | 1986 | — | 2 |
| Sega Fave | Japan | April 1998 | — | 1 |
| Sega Interactive | Japan | April 2015 | 1 | 3 |
| Sega of America | United States | March 10, 1986 | — | 2 |
| Sega Racing Studio | United Kingdom | 2005 | 1 | — |
| Sega Sammy Holdings | Japan | October 2004 | — | 3 |
| Sega Sports R&D | Japan | 1994 | 12 | — |
| SEGA Studios Australia | Australia | July 2002 | 1 | — |
| Sega Studios San Francisco | United States | 1999 | 3 | — |
| Sega Technical Institute | United States | 1991 | — | — |
| Sega Wow | Japan | 2003 | 18 | — |
| SegaSoft | United States | 1995 | 1 | — |
| Seibu Kaihatsu | Japan | 1982 | 8 | 5 |
| Sekai Project | United States | 2007 | 1 | 109 |
| Sengi Games | Ukraine | 2018 | 1 | — |
| Senile Team | Netherlands | 2003 | 1 | — |
| Sennari Games | United States | July 2000 | 1 | — |
| Sensible Software | United Kingdom | 1986 | 3 | — |
| Sensory Sweep Studios | United States | 2003 | 3 | — |
| Sente Technologies | — | 1982 | 1 | — |
| Seriously | Finland | 2013 | 1 | 1 |
| SETA Corporation | Japan | October 1985 | 3 | — |
| SFB Games | United Kingdom | September 2, 2002 | 3 | 2 |
| Shaba Games | United States | 1997 | 3 | — |
| Shall Luck Plus | Japan | 2002 | — | 1 |
| Sharkmob | Sweden | 2016 | 1 | 1 |
| Shift | Japan | June 1999 | 3 | — |
| Shift Up | South Korea | December 2, 2013 | 1 | — |
| Shin'en Multimedia | Germany | 1999 | 2 | 2 |
| Shiny Entertainment | United States | 1993 | 4 | — |
| Shiny Shoe | United States | 2011 | 1 | — |
| Shiravune | Japan | 2019 | — | 16 |
| Shiro Games | France | October 2012 | 2 | 2 |
| Shiver Entertainment | United States | 2012 | 1 | — |
| Shiver Games | Finland | 2010 | 3 | 3 |
| Shochiku | Japan | 1895 | — | 1 |
| Shockwave | United States | — | — | 1 |
| Shoeisha | Japan | 2006 | — | 1 |
| Shogakukan-Shueisha Productions | Japan | June 26, 1967 | 1 | 2 |
| Shrapnel Games | United States | 1999 | — | 4 |
| Shueisha Games | Japan | February 16, 2022 | — | 2 |
| Sickhead Games | United States | October 2002 | 1 | — |
| Sidhe | New Zealand | 1997 | 7 | — |
| Siemens Nixdorf Informationssysteme | Germany | October 1990 | — | 1 |
| Sierra Europe | United Kingdom | — | — | 1 |
| Sierra On-Line | United States | 1979 | — | 4 |
| Siesta | Japan | — | 1 | 1 |
| Signal Studios | United States | 2009 | 1 | — |
| Silesia Games | Poland | — | — | 6 |
| Silicon Dreams Studios | United Kingdom | March 1994 | 7 | — |
| Silicon Knights | Canada | 1992 | 2 | — |
| Silicon Studio | Japan | November 22, 1999 | 3 | — |
| Silky's | Japan | — | 4 | 4 |
| Silmarils | France | October 16, 1987 | 4 | 4 |
| Silver Bullet | Japan | — | — | 1 |
| Silver Style Entertainment | Germany | 1993 | 2 | — |
| Silverball Studios | United Kingdom | 2002 | 2 | — |
| SilverStarJapan Co., Ltd. | Japan | June 11, 1997 | — | — |
| SimBin | Sweden | 2003 | 2 | 1 |
| Simon & Schuster | United States | 1924 | 7 | 4 |
| Simrail S.A. | Poland | — | 1 | — |
| SIMS Co., Ltd. | Japan | June 12, 1991 | 6 | 1 |
| Simteract | Poland | — | 1 | — |
| Simtex | — | 1988 | 2 | — |
| Simutronics | United States | 1987 | 3 | 1 |
| SingleTrac | United States | 1995 | 3 | — |
| Sir-Tech | United States | 1979 | 10 | 10 |
| Sirlin Games | United States | 2005 | 1 | 1 |
| Sistema Brasileiro de Televisão | Brazil | August 19, 1981 | — | 1 |
| SITER SKAIN | Japan | — | 2 | — |
| Sixteen Tons Entertainment | Germany | 1998 | 2 | — |
| Size Five Games | United Kingdom | 2008 | 1 | 1 |
| Ska Studios | United States | 2001 | 2 | — |
| Skeleton Crew Studio | Japan | — | 1 | — |
| Skip Ltd. | Japan | July 2000 | 10 | — |
| Skipmore | Japan | — | 1 | — |
| Skitso Productions | Finland | 1995 | 2 | 1 |
| Skunkape Interactive | United States | — | 1 | — |
| Sky Bear Games | New Zealand | — | 1 | — |
| Sky Machine Studios | Australia | — | 1 | — |
| Skybound Entertainment | United States | 1992 | 1 | — |
| Skybound Games | United States | — | 1 | 6 |
| SkyBox Labs | Canada | 2011 | 3 | — |
| Skydance Media | United States | 2006 | 1 | 1 |
| Skydance TV | — | June 25, 1984 | — | 1 |
| SkyFallen Entertainment | Russia | 2002 | 2 | — |
| SkyTale Software GmbH | Austria | — | 1 | — |
| Slant Six Games | Canada | 2005 | 4 | — |
| Sledgehammer Games | United States | 2009 | 6 | 1 |
| SleepTeam | Czech Republic | 1996 | 2 | 2 |
| Slightly Mad Studios | United Kingdom | 2009 | 5 | 1 |
| Slipgate Ironworks | Denmark | 2010 | 2 | — |
| Slitherine Software UK Limited | United Kingdom | 2000 | 9 | 70 |
| Sloclap | France | May 2015 | 1 | 1 |
| Sluggerfly | Germany | — | 1 | — |
| Smack Down Productions | France | 2005 | 2 | — |
| Small Giant Games | Finland | 2013 | 1 | 1 |
| Smart Tale | France | — | 2 | — |
| Smartmelon Games | People's Republic of China | — | 1 | 1 |
| Smash House Games | United States | 2017 | 1 | 1 |
| SMEE | Japan | — | 1 | 1 |
| SMG Studio | Australia | July 2013 | 5 | 2 |
| SmileBoom | Japan | January 15, 2008 | 1 | 1 |
| Smilegate | South Korea | June 11, 2002 | 4 | 4 |
| Smoking Car Productions | United States | 1993 | 1 | — |
| Smoking Gun Interactive | Canada | 2007 | 3 | — |
| Smug Marmot Studios | United States | — | 1 | 1 |
| Snail | People's Republic of China | October 2000 | 2 | 1 |
| SneakyBox | Lithuania | — | 8 | 1 |
| Sniper Studios | United States | 2006 | 1 | — |
| SNK | Japan | December 2016 | 55 | 51 |
| SNK | Japan | April 1986 | 17 | 38 |
| SNK-Games | Russia | 2003 | 3 | — |
| Snoozy Kazoo | United States | May 2020 | 2 | — |
| Snow Cannon Games | Norway | — | — | 1 |
| Snowball Studios | Russia | 1996 | — | 2 |
| Snowblind Studios | United States | 1997 | 3 | — |
| Snowcastle Games | Norway | — | 3 | 2 |
| Snowman | Canada | 2012 | 4 | 2 |
| So Romantic | Taiwan | 2012 | 2 | — |
| Soaphog Game Studio | Latvia | 2016 | 1 | 1 |
| Social Democratic Party of Germany | Germany | May 23, 1863 | — | 1 |
| Soedesco | Netherlands | 2001 | — | 13 |
| Soft Leaf Studios | United Kingdom | 2019 | 1 | — |
| Soft-World International | Taiwan | 1983 | — | — |
| Softclub | Russia | 1994 | 1 | 17 |
| Softdisk | United States | 1981 | 3 | 5 |
| Softgold Computerspiele | Germany | 1986 | — | 3 |
| Softhouse Chara | Japan | 2000 | 8 | 8 |
| Softhouse-seal | Japan | 2009 | 1 | 2 |
| SoftLab-NSK | Russia | 1988 | — | — |
| Softmax | South Korea | October 28, 1994 | 2 | — |
| Softstar Entertainment | Taiwan | April 27, 1988 | 9 | 9 |
| Softstar Technology (Shanghai) Co., Ltd. | People's Republic of China | June 14, 2001 | 2 | — |
| Software 2000 | Germany | 1987 | 3 | 3 |
| Software Creations | United Kingdom | 1985 | 10 | — |
| Software Creations | United States | — | — | 1 |
| Software Projects | United Kingdom | 1983 | 1 | 2 |
| Sokaikan | United Kingdom | September 18, 2017 | 1 | — |
| Sokpop Collective | Netherlands | 2015 | 98 | 97 |
| Sold-Out Software | United Kingdom | 1997 | 1 | 5 |
| Soleil | Japan | August 2008 | 2 | — |
| SomaSim | United States | 2013 | 2 | — |
| Somethin' Else Sound Directions Ltd. | United Kingdom | 1991 | 1 | — |
| Sometimes You | Russia | — | 4 | 28 |
| SomniumSoft | Italy | — | — | 1 |
| Sonalysts (United States) | United States | 1973 | 1 | 1 |
| Sonic Powered | Japan | April 1998 | 2 | — |
| Sonic Team | Japan | 2000 | 74 | — |
| Sonka | Poland | — | 1 | — |
| Sonnori | South Korea | February 1998 | 1 | 1 |
| Sony | Japan | April 2021 | — | 1 |
| Sony Computer Entertainment America | United States | — | 1 | 6 |
| Sony Group | Japan | May 7, 1946 | 1 | 3 |
| Sony Imagesoft | United States | 1989 | — | — |
| Sony Interactive Entertainment | United States | April 2016 | 31 | 349 |
| Sony Interactive Studios America | United States | 1995 | 3 | — |
| Sony Music Entertainment Japan | Japan | March 11, 1968 | — | 3 |
| Sony Network Communications Inc. | Japan | November 1995 | — | 1 |
| Sony Pictures Digital | United States | 1997 | — | 1 |
| Sonzai Games | Japan | — | 1 | — |
| Sora Ltd. | Japan | 2005 | 5 | — |
| SORAYUME | Japan | September 21, 2005 | 1 | 1 |
| SoulGame Studio | France | December 16, 2019 | 4 | — |
| Southend Interactive | Sweden | — | 1 | — |
| SouthPeak Games | United States | 1996 | — | 7 |
| Space Lizard Studio | United Kingdom | — | 2 | 1 |
| Spark Unlimited | United States | 2002 | 2 | — |
| Sparkling Society | — | 2013 | 1 | 1 |
| Sparkypants Studios | United States | 2011 | 1 | — |
| Spearhead Games | Canada | 2012 | 1 | 1 |
| Specialbit | Ukraine | October 25, 2006 | 2 | 2 |
| Spectrum HoloByte | United States | 1983 | 2 | 5 |
| Spellbound Entertainment | Germany | 1994 | 8 | — |
| Spiderweb Software | United States | 1994 | 19 | 19 |
| Spike | Japan | 2005 | 15 | 16 |
| Spike Chunsoft | Japan | 2012 | 21 | 27 |
| Spil Games | Netherlands | 2001 | — | 1 |
| Spiral Circus | United Kingdom | October 23, 2018 | 1 | — |
| Spiral House | United Kingdom | 1998 | 1 | — |
| Spiral Up Games | Singapore | 2021 | — | 1 |
| Splash Damage | United Kingdom | April 30, 2001 | 6 | — |
| Spokko | Poland | — | 1 | — |
| Spooky Doorway | Ireland | — | 1 | — |
| Sports Interactive | United Kingdom | July 21, 1994 | 33 | — |
| Sports Mogul | United States | 1997 | — | — |
| Sporty Peppers | France | April 16, 2021 | 1 | 1 |
| Sprakelsoft | Germany | — | 3 | 3 |
| Springfish Co., Ltd. | Taiwan | October 24, 2018 | — | 1 |
| Springloaded | Singapore | — | 1 | — |
| Sproing Interactive Media | Austria | 2001 | 20 | 1 |
| Spry Fox | United States | 2010 | 3 | 2 |
| Square | Japan | September 1986 | 39 | 42 |
| Square Enix | Japan | 1975 | 107 | 243 |
| Square Enix Business Division 1 | Japan | December 2013 | 1 | — |
| Square Enix Montréal | — | 2011 | 2 | — |
| Squiddershins | United States | — | 2 | 1 |
| St.GIGA | Japan | 1990 | — | 3 |
| Stage Clear Studios | Spain | 2012 | 3 | — |
| Stainless Games | United Kingdom | 1993 | 5 | 3 |
| Stainless Steel Studios | United States | 1997 | 2 | — |
| Star Drifters | Poland | — | 2 | 2 |
| Starbreeze Studios | Sweden | 1998 | 5 | 5 |
| Starbyte | Germany | 1988 | 2 | 4 |
| Stardock | United States | 1991 | 14 | 12 |
| STARFISH-SD | Japan | 1994 | 1 | 3 |
| Starward Industries | Poland | 2018 | 1 | — |
| Starz Entertainment | United States | April 28, 1997 | — | 2 |
| State of Play | United Kingdom | 2008 | 5 | 5 |
| Steckenpferd Enterprises UG | Germany | — | — | 1 |
| Steel Mantis | United States | — | 1 | — |
| Steel Monkeys | — | 1998 | 2 | — |
| Stegosoft Games | United States | November 14, 2013 | 1 | — |
| Stellar Stone | United States | 2000 | 1 | — |
| Step Creative Group | United States | 1994 | 1 | — |
| Stern Electronics | United States | 1977 | 1 | 1 |
| Stillalive studios | Austria | 2010 | 6 | — |
| Sting | Japan | February 7, 1989 | 17 | 4 |
| Stone Lantern Games | United States | — | 1 | — |
| Stormfront Studios | United States | 1989 | 7 | — |
| Stormind Games | Italy | — | 2 | — |
| Stormling Studios | Turkey | — | 1 | — |
| StormRegion | — | 1997 | 2 | — |
| Straight Edge | Japan | April 2016 | — | — |
| Straka.studio | Slovakia | — | 1 | 1 |
| Strange Scaffold | United States | February 12, 2019 | 5 | 4 |
| Strategic Simulations | United States | 1979 | 15 | 28 |
| Strategy First | United Kingdom | 1988 | 4 | 39 |
| Stray Bombay | United States | — | 1 | 1 |
| Stray Fawn Studio | Switzerland | — | 2 | 2 |
| Stray Kite Studios | United States | — | 1 | — |
| Streum On Studio | — | August 2, 2007 | 1 | — |
| Striking Distance Studios | United States | 2019 | 1 | — |
| Studio 1-2 | Denmark | — | 12 | 1 |
| Studio 100 | Belgium | March 29, 1996 | — | 1 |
| Studio 33 | United Kingdom | 1998 | 3 | — |
| Studio Bside | South Korea | July 2017 | 1 | 1 |
| Studio Chien d'or | Canada | — | — | 1 |
| Studio Cypix | South Africa | — | 1 | 1 |
| Studio Drydock | Australia | — | 1 | 1 |
| Studio e.go! | Japan | 1998 | 14 | 10 |
| Studio Fizbin | Germany | 2011 | 4 | — |
| Studio Gamaii | Canada | — | 1 | 1 |
| Studio Huckepack | Germany | — | 1 | — |
| Studio Inkyfox UG | — | — | 1 | — |
| Studio Line | Japan | August 1997 | 1 | — |
| Studio Mebius | Japan | — | 2 | 2 |
| Studio Nue | Japan | 1972 | — | — |
| Studio Pango | France | 2012 | 1 | 1 |
| Studio Ryokucha | Japan | 2001 | 1 | 1 |
| Studio Saizensen | Japan | — | 7 | — |
| Studio Thunderhorse | United States | — | 1 | — |
| Studio Wildcard | — | 2014 | 1 | 1 |
| Stunlock Studios | Sweden | 2010 | 2 | 1 |
| Sublogic | United States | 1977 | 4 | 3 |
| Success | Japan | 1978 | 14 | 11 |
| Sugar Games | Russia | 2003 | 1 | 1 |
| Summitsoft Entertainment | United States | May 3, 1993 | — | 1 |
| Sumo Digital | United Kingdom | 2003 | 16 | 1 |
| Sumo Nottingham | United Kingdom | 2016 | 1 | — |
| Sumzap | Japan | — | 1 | 1 |
| Sun Microsystems | United States | February 24, 1982 | — | — |
| Sunborn Network Technology | People's Republic of China | October 2015 | 1 | 1 |
| Suncrash | Israel | December 2014 | 1 | — |
| Sundae Factory | — | — | 1 | 1 |
| SunDust | — | — | — | 2 |
| Sunflowers Interactive Entertainment Software | Germany | 1993 | — | 4 |
| Sungrand Studios | Australia | — | 2 | 2 |
| Sunhead Games | Taiwan | March 2012 | 3 | — |
| Sunlight Games | Germany | — | 2 | 2 |
| Sunna Entertainment | Costa Rica | 2014 | 1 | — |
| Sunnyside Games | Switzerland | 2013 | 3 | — |
| Sunrise Interactive | Japan | 1998 | 2 | — |
| Sunscorched Studios | United Kingdom | April 11, 2019 | 2 | 1 |
| Sunsoft | Japan | 1978 | 17 | 26 |
| Sunstorm Interactive | United States | 1995 | 6 | — |
| Suntendy Interactive Multimedia Co.,Ltd. | People's Republic of China | June 2, 1997 | — | 31 |
| Super Evil Megacorp | United States | 2012 | 1 | 1 |
| Super PowerUp Games | Spain | — | 6 | 13 |
| Super Rare Games | United Kingdom | October 25, 2017 | — | 1 |
| Super X Studios | United States | 1998 | 2 | 1 |
| Supercell | Finland | May 14, 2011 | 2 | 2 |
| SuperGaming | India | 2017 | 1 | 1 |
| Supergiant Games | United States | 2009 | 1 | 1 |
| Supergonk | United Kingdom | — | 1 | 1 |
| Superior Software | United Kingdom | 1982 | — | 1 |
| Supernova Games Studios | Italy | 2021 | 1 | — |
| Superscape | United Kingdom | 1983 | 4 | — |
| Supersonic Software | United Kingdom | 1989 | 1 | — |
| SuperVillain Studios | United States | 2004 | 3 | 1 |
| Supra Games | Germany | — | 2 | 2 |
| SureAI | Germany | 2003 | 2 | 2 |
| Surreal Software | United States | 1995 | 4 | — |
| Survios | United States | 2013 | 5 | 4 |
| Suspicious Developments | United Kingdom | 2012 | 1 | 1 |
| Suzak Inc. | Japan | June 26, 2000 | 4 | — |
| Sveriges Radio | Sweden | February 6, 1991 | 1 | 1 |
| Sveriges Television | Sweden | 1978 | 1 | 10 |
| SVG Distribution | — | 1980 | 1 | — |
| SVT Drama | Sweden | 1996 | — | 1 |
| Swan | Japan | October 5, 1995 | 7 | 7 |
| Sweet Baby Inc. | Canada | 2018 | 1 | — |
| Sweet Bandits Studios | Canada | 2016 | 1 | — |
| Swiss Agency for Development and Cooperation | Switzerland | 1960 | — | 1 |
| Swiss Federal Institute of Technology in Lausanne | Switzerland | 1969 | — | 1 |
| Swisscom | Switzerland | October 1997 | — | 1 |
| Swisslos | Switzerland | 1937 | — | 1 |
| Swordfish Studios | United Kingdom | 2002 | 1 | — |
| SwordSwipe Studios | United States | — | 1 | — |
| SYBO Games | Denmark | 2010 | 1 | 1 |
| Syn Sophia | Japan | 1995 | 15 | — |
| Synapse Software | United States | 1981 | 1 | — |
| Synergistic Software | United States | 1978 | 2 | 1 |
| Synetic GmbH | Germany | 1996 | 1 | — |
| System 3 | United Kingdom | 1984 | 6 | 4 |
| System Sacom | Japan | 1981 | 4 | 1 |
| SystemSoft | Japan | September 28, 1979 | 1 | 1 |
| SystemSoft Alpha | Japan | April 1999 | 1 | 7 |