| Crossnet | Japan | September 1999 | — | 1 |
| Crosstalk Inc. | Japan | October 1979 | 1 | — |
| Croteam | Croatia | 1993 | 29 | 14 |
| Croteam Publishing | Croatia | — | — | 2 |
| Croteam VR | Croatia | — | 3 | — |
| Crowd | Japan | — | 5 | 5 |
| CRT GAMES | South Korea | October 16, 2020 | 2 | — |
| Crunching Koalas | Poland | 2012 | — | 2 |
| Crunchyroll | United States | May 14, 2006 | — | 1 |
| Crunchyroll, LLC | United States | — | — | 2 |
| Cryo Interactive | France | 1992 | 11 | 4 |
| Cryptic Studios | United States | June 2000 | 2 | — |
| Crypton Future Media | Japan | July 1995 | 6 | 3 |
| Crystal Dynamics | United States | 1992 | 18 | 1 |
| Crytek UK | United Kingdom | 1999 | 6 | — |
| Crytivo Games | United States | — | — | 8 |
| CSP Mobile GmbH | Germany | 1999 | 4 | 4 |
| CTW Inc. | Japan | August 14, 2013 | — | 4 |
| CUFFS | Japan | 2005 | 2 | 4 |
| Culture Brain | Japan | 1980 | 7 | 4 |
| Culture Publishers | Japan | — | — | 1 |
| Curve Games | United Kingdom | December 14, 2005 | 1 | 22 |
| Cyan Worlds | United States | 1987 | 10 | 6 |
| Cyanide | France | 2000 | 21 | — |
| CyberConnect2 | Japan | February 16, 1996 | 31 | 3 |
| CyberFront | Japan | 1998 | — | 3 |
| Cyberlore Studios | United States | 1992 | 3 | — |
| CyberPlanet Interactive | Thailand | 2000 | 1 | — |
| CyberStep Holdings | Japan | April 2000 | 2 | 5 |
| CyberWorks | Japan | — | 1 | 1 |
| Cyborn | Belgium | 1998 | 1 | 1 |
| Cyclone Zero | Japan | July 2007 | 4 | — |
| Cygames | Japan | 2011 | 8 | 7 |
| Cypronia | Slovakia | 1996 | 8 | — |
| Czech Games Edition | Czech Republic | July 12, 2007 | — | 1 |
| D-Rockets | Japan | October 7, 2008 | 1 | — |
| D-techno | — | — | 1 | 1 |
| D3 Publisher | United States | February 5, 1992 | — | 113 |
| D3arts.cz | Czech Republic | 2008 | 1 | 1 |
| Daedalic Entertainment | Germany | 2007 | 10 | 28 |
| Daewon Media | South Korea | 1973 | — | 1 |
| Dalcom Soft | South Korea | March 2014 | 1 | — |
| DAMAGE STATE | United Kingdom | — | 1 | 1 |
| Dancing Dots | France | 2006 | 4 | — |
| Dangen Entertainment | Japan | 2017 | — | 10 |
| Danger Close Games | United States | 1995 | 13 | — |
| DangerousBob Studio | United States | — | 3 | 2 |
| Dark Energy Digital | United Kingdom | 1998 | 2 | 1 |
| Darkania Works | Romania | — | 2 | 1 |
| DarkArts Studios | South Africa | — | 1 | 1 |
| Darkflow Software | Latvia | — | 1 | — |
| Darkside Game Studios | United States | 2008 | 1 | — |
| Darkworks | France | 1998 | 1 | — |
| Darril Arts | Italy | — | — | 1 |
| Dassault Systèmes | Australia | 1981 | — | — |
| Data Design Interactive | United Kingdom | 1983 | 14 | 3 |
| Data East | Japan | April 20, 1976 | 23 | 21 |
| DATA WEST | Japan | May 26, 1986 | 3 | 3 |
| Datam Polystar | Japan | May 30, 1990 | 3 | 8 |
| Datamost | — | 1981 | — | 3 |
| Datasoft | United States | June 12, 1980 | 2 | 2 |
| Davilex | Netherlands | 1987 | 1 | 1 |
| Davilex Games | Netherlands | 1997 | 62 | 26 |
| Daybreak Game Company | United States | 1995 | 6 | 8 |
| Daydream Software | — | 1994 | 1 | 1 |
| DC Comics | United States | 1977 | — | 1 |
| DC Studios | United States | 1999 | 2 | — |
| DCF Studios | Brazil | — | 1 | 1 |
| Dead Drop Studios | United States | — | 3 | 3 |
| Deadline Games | Denmark | 1996 | 2 | — |
| Deadpan Games | United Kingdom | — | 1 | — |
| Dear Villagers | France | — | 1 | 14 |
| Debonosu Works | Japan | — | 2 | — |
| Deck13 Interactive | Germany | 2001 | 5 | 3 |
| Deconstructeam | — | 2012 | 2 | — |
| Deep Silver | Germany | 2002 | — | 52 |
| Deep Silver Dambuster Studios | United Kingdom | 2014 | 2 | — |
| Deep Silver Vienna | Austria | 2007 | — | 1 |
| Deepnight Games | France | June 8, 2020 | 1 | 1 |
| Defiant Development | Australia | — | 2 | 2 |
| Defrost Games | Sweden | 2010 | 1 | — |
| Degica | Japan | June 13, 2005 | 1 | 4 |
| Dejobaan Games | United States | 1999 | 1 | 1 |
| Delightworks | Japan | — | — | 1 |
| Delphine Software International | France | 1988 | 6 | — |
| Delta 4 | United Kingdom | 1984 | 2 | — |
| Demonware | Ireland | 2003 | 1 | — |
| DeNA | Japan | March 1999 | 6 | 1 |
| Denda Games | Netherlands | 2007 | — | 7 |
| Denki | United Kingdom | 2000 | 1 | — |
| Dennaton Games | Sweden | 2012 | 2 | — |
| Design Factory | Japan | April 2, 2001 | 12 | — |
| Destination Software Inc. | United States | 2001 | — | 2 |
| Destineer | United States | 2001 | 1 | 3 |
| Destructive Creations | Poland | 2014 | 2 | 2 |
| Detach Entertainment | Germany | 2019 | 1 | 1 |
| Dev4Play | Poland | — | — | 1 |
| Development Studio | Sweden | 1995 | 14 | — |
| Devespresso Games | South Korea | 2014 | 4 | 1 |
| DevilishGames | Spain | 1998 | 1 | — |