- Advantage TennisReleased: 1991Platforms: FM Towns, Atari ST
- Adventures of Lolo 2Developer: HAL LaboratorySeries: Eggerland
- AknadachReleased: 1991Platforms: ZX Spectrum
- Are We There Yet?Released: 1991Platforms: DOS
- ATP Tour SimulatorReleased: 1991Platforms: ZX Spectrum
- Back to the Future Part IIIDeveloper: Acclaim Studios LondonReleased: 1991
- Banzai: Death Sortie of the YamatoReleased: 1991Platforms: Apple II series
- Battle IsleDeveloper: Ubisoft Blue ByteSeries: Battle Isle
- BattletoadsDeveloper: Rare Ltd.Released: 1991
- BoingmasterReleased: 1991Platforms: Commodore 64
- Bomberman IIDeveloper: Hudson SoftReleased: 1991
- Bonk's RevengeDeveloper: Red EntertainmentSeries: Bonk
- Brigade CommanderReleased: 1991
- Budokan: The Martial SpiritDeveloper: Electronic ArtsReleased: 1991
- CashDeveloper: Max DesignReleased: 1991
- Championship ShootingDeveloper: Golden Gate CrewReleased: 1991
- Chuck Yeager's Air CombatDeveloper: Brent IversonReleased: 1991
- Commander Keen in Aliens Ate My BabysitterSeries: Commander KeenReleased: 1991
- Commander Keen in Goodbye, GalaxySeries: Commander KeenReleased: 1991
- Commander Keen in Keen DreamsSeries: Commander KeenReleased: 1991
- Conan: The CimmerianDeveloper: Synergistic SoftwareReleased: 1991
- Crisis in the KremlinReleased: 1991Publisher: MicroProse
- Dactyl NightmareReleased: 1991Platforms: Virtuality
- Death Knights of KrynnDeveloper: Strategic SimulationsSeries: Gold Box
- DeuterosReleased: 1991Platforms: Atari ST
- DingsdaDeveloper: Digital ExcessReleased: 1991
- Earl Weaver Baseball IIReleased: 1991Publisher: Electronic Arts
- EcoQuest: The Search for CetusSeries: EcoQuestReleased: 1991
- ElfDeveloper: Ocean SoftwareReleased: 1991
- Elite PlusReleased: 1991Publisher: MicroProse
- Fantasy GamesDeveloper: SilverbyteReleased: 1991
- Fighter Duel: Corsair vs. ZeroReleased: 1991
- Free D.C!Released: 1991Platforms: DOS
- G.I. JoeReleased: 1991Publisher: Taxan
- Galactic FrontiersReleased: 1991Platforms: Classic Mac OS
- Gateway to the Savage FrontierDeveloper: Stormfront StudiosSeries: Gold Box
- Ghost BattleReleased: 1991Publisher: Thalion Software
- GobliiinsDeveloper: Coktel VisionSeries: Gobliiins
- Golden Axe WarriorSeries: Golden AxeReleased: 1991
- Gremlins 2: The New BatchSeries: GremlinsReleased: 1991
- Hare Raising HavocDeveloper: BlueSky SoftwareReleased: 1991
- HB Fahrfestival 91Released: 1991Publisher: Starbyte
- HexagoniaReleased: 1991Platforms: ZX Spectrum
- Hugo II, Whodunit?Released: 1991Platforms: DOS
- James Pond 2: Codename: RoboCodReleased: 1991Platforms: DOS, Super Nintendo Entertainment System, Acorn Archimedes, Amiga 1200, Atari ST, Commodore 64
- JetmanReleased: 1991Genre: multidirectional shooter
- Jméno růžeReleased: 1991Platforms: ZX Spectrum, Didaktik
- John Madden Football '92Developer: Electronic ArtsSeries: Madden NFL
- John Madden Football IISeries: Madden NFLReleased: 1991
- Jonny Quest in Doctor Zim's UnderworldReleased: 1991Platforms: ZX Spectrum
- Jumbo Ozaki no Hole In OneReleased: 1991Platforms: Super Nintendo Entertainment System
- Just Another War in SpaceDeveloper: Azeroth, Inc.Released: 1991
- King of the MonstersDeveloper: SNKReleased: 1991
- Knights of XentarDeveloper: ELF CorporationSeries: Dragon Knight
- Les Manley in: Lost in LADeveloper: AccoladeReleased: 1991
- Line of FireReleased: 1991
- Little Ninja BrothersDeveloper: Culture BrainSeries: Super Chinese
- Lotus Turbo Challenge 2Series: LotusReleased: 1991
- Mad TVDeveloper: Rainbow ArtsReleased: 1991
- Master of Monsters 2Released: 1991Platforms: NEC PC-9800 series
- MicroLeague Baseball: The Manager's ChallengeReleased: 1991Platforms: DOS
- Miecze ValdgiraDeveloper: ASF s.c.Released: 1991
- MiG-29M Super FulcrumReleased: 1991Publisher: Domark Software
- Might and Magic III: Isles of TerraDeveloper: New World ComputingReleased: 1991
- Mission: ImpossibleDeveloper: KonamiReleased: 1991
- Mixed-Up Fairy TalesReleased: 1991Platforms: DOS
- Monkey Island 2: LeChuck's RevengeDeveloper: Lucasfilm GamesSeries: Monkey Island
- MonopolyDeveloper: Sculptured SoftwareSeries: Monopoly
- Napoleon I: The Campaigns 1805-1814Released: 1991Platforms: Atari ST
- NCAA Basketball: Road to the Final FourReleased: 1991Platforms: DOS
- NeighboursReleased: 1991Publisher: Zeppelin Games
- Neighbours: The AdventureReleased: 1991Genre: point-and-click adventure
- Neverwinter NightsDeveloper: Stormfront StudiosSeries: Gold Box
- NHL HockeyDeveloper: Park Place ProductionsReleased: 1991
- NibblesReleased: 1991Publisher: Microsoft
- Nintendo Campus Challenge 1991Developer: NintendoSeries: Nintendo Campus Challenge
- Out Run EuropaDeveloper: Acclaim Studios LondonSeries: OutRun
- Paperboy 2Developer: TengenReleased: 1991
- PoizoneDeveloper: Evolution Trading AGReleased: 1991
- Police Quest III: The KindredSeries: Police QuestReleased: 1991
- Pools of DarknessDeveloper: Strategic SimulationsSeries: Gold Box, Pool of Radiance
- Populous II: Trials of the Olympian GodsDeveloper: Bullfrog ProductionsSeries: Populous
- PrehistorikDeveloper: Titus InteractiveReleased: 1991
- Princess MakerSeries: Princess MakerReleased: 1991
- QUOVADISReleased: 1991Publisher: Swiss Federal Institute of Technology in Lausanne
- R.B.I. Baseball 3Series: R.B.I. BaseballReleased: 1991
- RevelationDeveloper: Krisalis SoftwareReleased: 1991
- Rogue TrooperDeveloper: Krisalis SoftwareReleased: 1991
- Rychlé šípy 2 - Stínadla se bouříReleased: 1991Platforms: ZX Spectrum
- Saint Seiya : Ougon DensetsuDeveloper: Tose Co.Released: 1991
- SegaSonic Cosmo FighterDeveloper: Sega WowSeries: Sonic the Hedgehog
- Sonic EraserDeveloper: Sonic TeamSeries: Sonic the Hedgehog
- Spellcasting 201: The Sorcerer's ApplianceDeveloper: Legend EntertainmentReleased: 1991
- Spike in TransylvaniaReleased: 1991Publisher: Codemasters
- Steigenberger HotelmanagerReleased: 1991Platforms: DOS, Commodore 64
- Super Kick OffSeries: Kick OffReleased: 1991
- Super Mario World Mario to Yoshi no Bōken LandReleased: 1991Publisher: Bandai
- Super SkweekDeveloper: LoricielsReleased: 1991
- Super TetrisDeveloper: Spectrum HoloByteReleased: 1991
- SUPER World StadiumDeveloper: NamcoReleased: 1991
- TangramReleased: 1991Publisher: Thalion Software
- Terminator 2: Judgment DayReleased: 1991Publisher: Ocean Software
- Terminator 2: Judgment DayReleased: 1991Platforms: Game Boy
- The Addams FamilyReleased: 1991Platforms: TurboGrafx-16
- The Bard's Tale Construction SetDeveloper: Interplay EntertainmentSeries: The Bard's Tale
- The BrainiesReleased: 1991Publisher: Titus Interactive
- The Bugs Bunny Cartoon WorkshopReleased: 1991Platforms: Classic Mac OS
- The Chessmaster 3000Series: ChessmasterReleased: 1991
- The Simpsons: Bart vs. the Space MutantsDeveloper: ImagineeringReleased: 1991
- The Simpsons: Bart vs. the WorldDeveloper: ImagineeringReleased: 1991
- The Space AdventureDeveloper: Hudson SoftReleased: 1991
- Thunder Cross IIDeveloper: KonamiReleased: 1991
- Top Gun: Danger ZoneDeveloper: KonamiReleased: 1991
- Toto se promèneReleased: 1991Publisher: Epsitec SA
- Trex Warrior: 22nd Century GladiatorReleased: 1991Publisher: Thalion Software
- Trump Castle IISeries: Trump CastleReleased: 1991
- Tsurikko PentaReleased: 1991Platforms: arcade video game machine
- UMS II: Nations at WarDeveloper: Intergalactic DevelopmentReleased: 1991
- V for Victory: D-Day Utah BeachDeveloper: Atomic GamesSeries: V for Victory
- Wacky Races: Dastardly and MuttleyReleased: 1991Platforms: 3DO, ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64
- Wagan LandSeries: Wagan LandReleased: 1991
- Warlock: The AvengerReleased: 1991Platforms: Atari ST, Commodore 64
- Wild WheelsDeveloper: Ocean SoftwareReleased: 1991
- Wing Commander II: Vengeance of the KilrathiDeveloper: Origin SystemsSeries: Wing Commander
- Worldwide HuntingDeveloper: Golden Gate CrewReleased: 1991
- WWF WrestleManiaDeveloper: TwilightSeries: WWE 2K
- Xak: The Tower of GazzelDeveloper: MicrocabinReleased: 1991
- XaromDeveloper: SilverbyteReleased: 1991
- Mega Man 2Developer: CapcomSeries: Mega Man, Mega Man Legacy Collection
- Juvei QuestDeveloper: BirthdayReleased: January 4, 1991
- Operation CDeveloper: KonamiReleased: January 8, 1991
- Golf Grand SlamDeveloper: Tose Co.Released: January 31, 1991
- Last Ninja 2Developer: System 3Series: The Last Ninja
- Street Fighter IIDeveloper: CapcomReleased: February 6, 1991
- Dark LordDeveloper: Data EastReleased: February 8, 1991
- Mikeneko Homuzu no KishidoReleased: February 15, 1991Platforms: Game Boy
- Parasol Henbē: Otogi no Kuni wa Ōsawagi!Developer: Sakata SAS Co., Ltd.Released: February 15, 1991
- Adventures of LoloDeveloper: HAL LaboratorySeries: Eggerland
- Gremlins 2: The New BatchDeveloper: SunsoftSeries: Gremlins
- King's BountyDeveloper: New World ComputingReleased: February 21, 1991
- All OneSeries: Famimaga DiskReleased: February 22, 1991
- Niji no SilkroadDeveloper: NHKReleased: February 22, 1991
- Grand MasterDeveloper: Soft MachineReleased: February 26, 1991
- Teenage Mutant Ninja Turtles: Turtles in TimeDeveloper: KonamiReleased: March 1991
- Space Quest IVSeries: Space QuestReleased: March 4, 1991
- The SimpsonsDeveloper: KonamiReleased: March 4, 1991
- Advanced Dungeons & Dragons: HillsfarDeveloper: Crosstalk Inc.Released: March 21, 1991
- Itadaki Street: Watashi no Omise ni YottetteDeveloper: Game StudioReleased: March 21, 1991
- Shadow BrainDeveloper: Scitron & Art Inc.Released: March 21, 1991
- Shining in the DarknessDeveloper: Climax EntertainmentSeries: Shining
- Fantastic DizzyDeveloper: Oliver TwinsSeries: Dizzy
- HEARTS & BONESReleased: April 1991Platforms: HP 95LX
- TigerFoxReleased: April 1991Platforms: HP 95LX
- Tenchi wo Kurau IIDeveloper: CapcomReleased: April 5, 1991
- Uncharted WatersDeveloper: KoeiSeries: Uncharted Waters
- Cave NoireDeveloper: KonamiReleased: April 19, 1991
- CloxSeries: Famimaga DiskReleased: April 19, 1991
- LangrisserDeveloper: Career SoftSeries: Langrisser
- Sim CityDeveloper: Electronic ArtsSeries: SimCity
- The Bugs Bunny Crazy Castle 2Developer: KemcoReleased: April 26, 1991
- The G.G. ShinobiReleased: April 26, 1991Genre: action game, platform game
- ShockmanSeries: Kaizō Chōjin ShubibinmanReleased: April 27, 1991
- Family FeudDeveloper: Krome Studios MelbourneSeries: Family Feud
- CocoronDeveloper: TakeruReleased: May 3, 1991
- Super Bases LoadedDeveloper: Tose Co.Released: May 17, 1991
- Game Boy WarsDeveloper: Hudson Soft, Intelligent SystemsSeries: Wars
- Yet Another Tetris CloneReleased: May 30, 1991
- BattletoadsDeveloper: Rare Ltd.Released: June 1991
- Skate or Die: Tour de ThrashDeveloper: Electronic ArtsReleased: June 1991
- Teenage Mutant Ninja Turtles: Manhattan MissionsDeveloper: Distinctive SoftwareReleased: June 1, 1991
- Final Fantasy AdventureDeveloper: SquareSeries: Mana
- 4D Sports BoxingDeveloper: Distinctive SoftwareReleased: June 15, 1991
- Choplifter IIDeveloper: Krome Studios MelbourneReleased: June 21, 1991
- Ninja Gaiden III: The Ancient Ship of DoomDeveloper: TecmoSeries: Ninja Gaiden
- Sonic the HedgehogDeveloper: Sonic Team, KonamiSeries: Sonic the Hedgehog
- Dr. MarioDeveloper: Nintendo Research & Development 1Series: Mario
- Sugoro Quest: Dice HeroesDeveloper: Technōs JapanReleased: June 28, 1991
- Duke NukemDeveloper: Apogee SoftwareReleased: July 1991
- Leisure Suit Larry 1: In the Land of the Lounge LizardsSeries: Leisure Suit LarryReleased: July 1, 1991
- RaidenDeveloper: Seibu KaihatsuSeries: Raiden
- Castlevania II: Belmont's RevengeDeveloper: KonamiReleased: July 12, 1991
- F1 Circus '91Developer: MicronicsReleased: July 12, 1991
- The Legend of the Mystical NinjaDeveloper: KonamiReleased: July 17, 1991
- Final Fantasy IVDeveloper: SquareReleased: July 19, 1991
- Battle Dodge Ball: Toukyuu Daigekitotsu!Released: July 20, 1991Platforms: Super Nintendo Entertainment System
- Power ElevenDeveloper: Westone Bit EntertainmentReleased: July 21, 1991
- Downtown Special: Kunio-kun's Historical Period Drama!Developer: Technōs JapanReleased: July 26, 1991
- Mega Man: Dr. Wily's RevengeDeveloper: CapcomSeries: Mega Man
- Namachuukei 68Developer: KonamiReleased: July 30, 1991
- Streets of RageReleased: August 2, 1991Platforms: Microsoft Windows, macOS, Linux, Android
- Dragon SaberDeveloper: NamcoReleased: August 5, 1991
- Gradius: The Interstellar AssaultDeveloper: KonamiReleased: August 9, 1991
- Hyaku no Sekai no Monogatari: The Tales on a Watery WildernessDeveloper: ASK Kodansha Co., Ltd.Released: August 9, 1991
- SuperDepthReleased: August 10, 1991Platforms: NEC PC-9800 series
- Space Quest I: Roger Wilco in the Sarien EncounterReleased: August 20, 1991Engine: Sierra's Creative Interpreter
- Blaster Master Jr.Developer: AicomReleased: August 23, 1991
- F-ZeroDeveloper: Nintendo Entertainment Analysis & DevelopmentSeries: F-Zero
- Super Mario Bros. 3Developer: Nintendo Entertainment Analysis & DevelopmentSeries: Mario
- Fire Pro Wrestling 2nd BoutDeveloper: Human EntertainmentSeries: Fire Pro Wrestling
- Kaiketsu Yanchamaru 2: Karakuri LandDeveloper: IremReleased: August 30, 1991
- Hyper ZoneDeveloper: HAL LaboratoryReleased: August 31, 1991
- Adventures of Lolo 3Developer: HAL LaboratorySeries: Eggerland
- Atomic PunkDeveloper: IremReleased: September 1991
- CivilizationDeveloper: MicroProseReleased: September 1991
- Final FightDeveloper: CapcomSeries: Final Fight
- Nebulus 2: Pogo a gogoReleased: September 1991Genre: puzzle video game
- Road RashDeveloper: Electronic ArtsSeries: Road Rash
- Super Jeopardy!Developer: GameTekReleased: September 1991
- Leisure Suit Larry 5: Passionate Patti Does a Little Undercover WorkSeries: Leisure Suit LarryReleased: September 7, 1991
- DezaemonDeveloper: AthenaReleased: September 13, 1991
- Smart BallDeveloper: Game FreakReleased: September 13, 1991
- NES Open Tournament GolfDeveloper: Nintendo Research & Development 2Released: September 20, 1991
- Solar JetmanDeveloper: Zippo GamesReleased: September 26, 1991
- Aretha IIReleased: September 27, 1991Platforms: Game Boy
- Sid Meier's Pirates!Developer: MicroProseReleased: October 1991
- Mario the JugglerDeveloper: NintendoReleased: October 14, 1991
- Rance III – Fall of Leazas –Developer: AliceSoftSeries: Rance
- Crystal CavesDeveloper: Apogee SoftwareReleased: October 23, 1991
- Top Gun: The Second MissionDeveloper: KonamiReleased: October 24, 1991
- Mahjong Vanilla SyndromeReleased: October 25, 1991Platforms: TurboGrafx-16, NEC PC-9800 series, arcade video game machine
- Sonic the HedgehogDeveloper: AncientReleased: October 25, 1991
- Bart Simpson's Escape from Camp DeadlyDeveloper: ImagineeringReleased: November 1991
- Metroid II: Return of SamusDeveloper: Nintendo Research & Development 1Released: November 1991
- The Bard's TaleDeveloper: Interplay EntertainmentSeries: The Bard's Tale
- Ax Battler: A Legend of Golden AxeDeveloper: AspectSeries: Golden Axe
- Ninja GaidenSeries: Ninja GaidenReleased: November 1, 1991
- Who Framed Roger RabbitDeveloper: CapcomReleased: November 1, 1991
- Teenage Mutant Ninja Turtles II: Back from the SewersDeveloper: KonamiReleased: November 15, 1991
- Lady PhantomReleased: November 29, 1991Publisher: Telenet Japan
- Ninja Boy IIDeveloper: Culture BrainSeries: Super Chinese
- Mônica no Castelo do DragãoDeveloper: TectoySeries: Monica and Friends
- Ranma ½: Toraware no HanayomeDeveloper: TENKYReleased: December 6, 1991
- Snow Bros.: Nick and TomDeveloper: ToaplanSeries: Snow Bros.
- Crystal WarriorsReleased: December 13, 1991Platforms: Nintendo 3DS
- Final Fantasy Legend IIIDeveloper: SquareSeries: SaGa, Final Fantasy Legend
- Ninja Gaiden ShadowDeveloper: TecmoSeries: Ninja Gaiden
- Super Wagan LandSeries: Wagan LandReleased: December 13, 1991
- Tecmo Super BowlDeveloper: TecmoReleased: December 13, 1991
- Teenage Mutant Ninja Turtles III: The Manhattan ProjectDeveloper: KonamiReleased: December 13, 1991
- Tetris 2 + BomblissDeveloper: ChunsoftReleased: December 13, 1991
- YoshiDeveloper: Game FreakReleased: December 14, 1991
- Mega Man IISeries: Mega ManReleased: December 20, 1991
- Super Momotaro Dentetsu ⅡReleased: December 20, 1991Platforms: Super Nintendo Entertainment System
- Ganbare Goemon: Sarawareta Ebisumaru!Developer: KonamiReleased: December 25, 1991
- Wacky RacesDeveloper: FumariaceaeReleased: December 25, 1991
- Golden Axe IISeries: Golden AxeReleased: December 27, 1991
- GG AlesteSeries: Power StrikeReleased: December 29, 1991