| Da Capo | 18 | adventure video game, visual novel | Circus |
| Daisenryaku | 2 | turn-based strategy video game | SystemSoft, Genki |
| Danball Senki | 4 | action anime and manga, role-playing video game | — |
| Dance Central | 3 | music video game | Xbox Game Studios |
| Dance Dance Revolution | 64 | music video game | Konami |
| Dance Dance Revolution Dance Wars | — | music video game | Konami |
| Dance Praise | 1 | music video game | — |
| Dancing Stage | 1 | music video game | — |
| Darius | 4 | shoot 'em up, science fiction | Taito |
| Dark Parables | 1 | adventure video game | — |
| Dark Seal | 2 | action role-playing game, beat 'em up | — |
| Dark Souls | 3 | action role-playing game | Bandai Namco Entertainment, FromSoftware |
| Darksiders | 5 | post-apocalyptic video game | — |
| Darkstalkers | 9 | 2D fighting game | — |
| Daymare | 2 | survival horror, action-adventure game | Leonardo Interactive, Destructive Creations, All in! Games |
| Daymare Town | — | point-and-click adventure | — |
| DC Super Hero Girls | 2 | comedy drama | — |
| Dead Island | 7 | action role-playing game | — |
| Dead or Alive | 23 | fighting game | Koei Tecmo Games |
| Dead or Alive Xtreme | 10 | minigame collection, beach volleyball video game, fan service | Koei Tecmo Games |
| Dead Space | 6 | survival horror, third-person shooter | Electronic Arts |
| Dead to Rights | 5 | third-person shooter | — |
| Deadtime Stories | — | puzzle video game | Big Fish Games |
| DearS | 1 | ecchi, science fiction anime and manga, harem | MediaWorks |
| Death Stranding | 1 | — | — |
| DecAthlete | 2 | sports video game | — |
| Deception | 3 | strategy video game | — |
| Deep Dungeon | 4 | role-playing video game | Square, Asmik Ace Entertainment |
| Deep Sleep | 4 | point-and-click adventure, adventure video game | — |
| Deer Avenger | 2 | action game | Simon & Schuster |
| Deer Hunter | 2 | first-person shooter, hunting video game | Atari |
| Deluxe Ski Jump | 4 | ski jumping video game | Mediamond |
| Dementium | 2 | first-person shooter, survival horror | — |
| Densha de Go! | 5 | train simulator | Taito |
| Dept. Heaven | 7 | role-playing video game | — |
| Descent | 3 | first-person shooter | Interplay Entertainment |
| Destiny | 7 | post-apocalyptic video game | — |
| Destruction Derby | 5 | racing video game | — |
| Detective Grimoire series | 3 | detective video game | — |
| Devil Summoner Series | 6 | role-playing video game | — |
| Diablo | 9 | dungeon crawl, action role-playing game | Blizzard Entertainment |
| Diabolik Lovers | 7 | otome game, visual novel, dark fantasy | Idea Factory |
| Digimon | 1 | — | — |
| Dino Crisis | 5 | survival horror | Capcom |
| Disaster Report | 5 | survival game, action-adventure game | NIS America, Granzella, Bandai Namco Entertainment, 505 Games, Agetec, Irem |
| Disciples | 11 | fantasy video game | — |
| Disgaea | 14 | tactical role-playing game | — |
| Dishonored | 3 | action-adventure game | — |
| Disney Infinity | 1 | crossover fiction | — |
| Disney Sports | 6 | — | — |
| Disney's Activity Center | — | jigsaw puzzle video game, point-and-click adventure, memory video game, educational video game, minigame collection, connect the dots video game, simon says video game, maze video game | Disney Interactive Studios, Tandem Verlag |
| Disney's Magical Quest | 3 | platform game | Capcom |
| Divinity | 2 | role-playing video game | — |
| Dizzy | 12 | adventure video game, puzzle video game, platform game | Codemasters |
| Djibril – The Devil Angel | — | eroge, hentai, visual novel, magical girl anime and manga | — |
| DJMax | 1 | rhythm game, music video game | — |
| Doctor Who: The Adventure Games | 5 | adventure video game | — |
| Dokapon | 7 | role-playing video game, party video game | — |
| Doko Demo Issyo | 16 | — | Sony Interactive Entertainment |
| Dominions | 5 | turn-based strategy video game | — |
| Don't Escape | 6 | — | — |
| Double Breakout | 1 | Breakout clone | nuGAME |
| Double Dragon | 12 | beat 'em up | — |
| Dr. Brain | 1 | adventure video game | — |
| Dracula Series | 1 | adventure video game | Wanadoo |
| Dragon Age | 9 | role-playing video game | Electronic Arts |
| Dragon Ball Z: Budokai | 7 | music of Japan | — |
| Dragon Ball Z: Budokai Tenkaichi | 4 | fighting game | — |
| Dragon Knight | 4 | eroge, fantasy anime and manga, hentai, visual novel, role-playing video game | — |
| Dragon Quest | 38 | fantasy anime and manga, Japanese role-playing video game, role-playing video game | Square Enix |
| Dragon Slayer | 7 | role-playing video game | — |
| Dragon's Lair | 1 | fantasy video game | — |
| Drakan | 2 | action-adventure game | SCE Studio Liverpool |
| Drakengard | 8 | action role-playing game | — |
| Drawn | — | puzzle video game | Big Fish Games |
| Dune | 4 | real-time strategy | — |
| Dungeon Defenders | 5 | — | — |
| Dying Light | 6 | action game, survival horror, role-playing video game | — |
| Dynasty Tactics | 2 | turn-based strategy video game | Koei |
| Dynasty Warriors | 37 | hack and slash | Koei |
| Dōsōkai | 4 | eroge, visual novel | — |