| M2 Shot Triggers | 3 | — | M2 |
| Macross | 2 | — | — |
| Madden NFL | 43 | American football video game | EA Sports |
| Madō Monogatari | 3 | role-playing video game | — |
| Mafia | 8 | action-adventure game, third-person shooter | Gathering of Developers, 2K |
| Magic Ball | 4 | — | — |
| Majin Tensei | 4 | tactical role-playing game | — |
| Make My Video | — | — | Sony Imagesoft |
| Mana | 12 | action role-playing game | — |
| Manchester United | 1 | association football video game | — |
| Manhunt | 1 | psychological horror fiction, stealth game | — |
| Marathon | 2 | first-person shooter, science fiction video game | — |
| Mario | 16 | educational video game, adventure video game, puzzle video game, role-playing video game, party video game, platform game, racing video game, sports video game | Nintendo |
| Mario | 1 | adventure video game, puzzle video game, role-playing video game, party video game, platform game, racing video game, sports video game | — |
| Mario & Luigi | 8 | role-playing video game | Nintendo |
| Mario & Sonic at the Olympic Games | 6 | olympic video game | — |
| Mario Artist | 4 | — | Nintendo |
| Mario Party | 19 | party video game | Nintendo |
| Mario Tennis | 10 | sports video game | Nintendo |
| Max Payne | 3 | third-person shooter | 3D Realms |
| MechWarrior | 7 | mech simulation game | — |
| Medal of Honor | 15 | first-person shooter | Electronic Arts |
| MediEvil | 4 | hack and slash, action-adventure game | Sony Interactive Entertainment |
| Mega Man | 23 | action game, platform game | — |
| Mega Man Battle Network | 16 | role-playing video game | — |
| Mega Man Legends | 4 | action game, science fiction video game | — |
| Mega Man X | 15 | action game, science fiction video game | — |
| Mega Man Zero | 6 | action game | Capcom |
| Mega Man ZX | 3 | — | — |
| Megami Tensei | 26 | science fantasy video game, cyberpunk video game, role-playing video game | Namco |
| Megami Tensei Gaiden: Last Bible | 5 | role-playing video game | — |
| Meiji Tokyo Renka | 1 | time-travel television program, otome game | — |
| Melty Blood | 3 | visual novel, fighting game | — |
| Memories Off | 12 | visual novel | — |
| Memories Off After Rain | — | drama anime and manga, visual novel | — |
| Memory Clip | — | — | City Connection |
| Men of War | 12 | real-time tactics | Softclub |
| Mercenaries | 2 | action-adventure game | — |
| Metal Gear | 25 | cyberpunk video game, stealth game | Konami |
| Metal Slug | 17 | shoot 'em up | SNK |
| Mia's Big Adventure Collection | 4 | — | — |
| Micro Machines | 1 | racing video game | Ocean Software, Midway Games, Codemasters, Camerica |
| Microsoft Baseball | 3 | baseball video game | — |
| Microsoft Combat Flight Simulator | 3 | combat flight simulator game | Microsoft |
| Midnight Club | 4 | arcade, racing video game | — |
| Midtown Madness | 3 | racing video game | Xbox Game Studios |
| Midway Arcade Treasures | 6 | — | Midway Home Entertainment, Success, Warner Bros. Games, Zushi Games |
| Mikagura Shōjo Tanteidan | 3 | eroge, murder mystery game, visual novel | — |
| Milk Junkies | — | eroge | — |
| Million Arthur | 1 | — | Square Enix |
| Minecraft | 1 | sandbox game | — |
| MLB Slugfest | 1 | — | — |
| MLB: The Show | 19 | sports video game | — |
| Modern Combat | 8 | first-person shooter | — |
| Moegaku | — | magical girl anime and manga | Idea Factory |
| Momotarō Densetsu | 4 | role-playing video game | — |
| Monkey Island | 9 | adventure video game | Lucasfilm Games |
| Monopoly | 7 | board video game | Parker Brothers |
| Monster Box | 2 | monster-taming game | YSO Corp |
| Monster Energy Supercross: The Official Videogame | 6 | supercross racing video game | Milestone S.r.l. |
| Monster Girl Quest | 3 | eroge, fantasy video game, episodic video game, visual novel, harem | — |
| Monster Rancher | 13 | role-playing video game | — |
| Monster Truck Madness | 2 | racing video game | — |
| Mortal Kombat | 26 | fighting game | Midway Games, Warner Bros. Games |
| Motocross Madness | 3 | vehicle simulation game, racing video game | — |
| MotoGP | 18 | racing video game | — |
| MotorStorm | 5 | racing video game | — |
| Mount & Blade | 4 | — | — |
| MX vs. ATV | 5 | racing video game | — |
| MXGP | 8 | motocross racing video game | — |
| My Coach | 4 | — | — |
| My Little Pony | 2 | — | THQ |
| My Time | 3 | — | — |
| MySims | 7 | life simulation game | Electronic Arts |
| Myst | 10 | adventure video game | Broderbund |
| Mystery Case Files | 32 | casual game, adventure video game, hidden object game | Big Fish Games |
| Mystery Dungeon | 10 | roguelike, adventure video game | — |
| Myth | 3 | real-time tactics | — |