| S.T.A.L.K.E.R. | 7 | post-apocalyptic video game, first-person shooter, science fiction video game, survival horror, role-playing video game | GSC Game World, Deep Silver, THQ |
| Sacred | 4 | action role-playing game | — |
| SaGa | 11 | role-playing video game | — |
| Sailor Moon | 2 | tactical role-playing game, beat 'em up | Banpresto, Bandai |
| Sakura Wars | 7 | dating sim, action role-playing game, tactical role-playing game, harem | — |
| Samorost | 3 | graphic adventure game, art game | Amanita Design |
| Samurai Shodown | 5 | 2D fighting game, 3D fighting game | SNK |
| Sargon | 1 | chess video game | — |
| Saturn Tribute | 8 | — | City Connection |
| SBK | 7 | racing video game | — |
| Scene It? | 5 | trivia video game, party video game | — |
| Science Adventure | 8 | science fiction video game, visual novel | — |
| Scoob! | 1 | mystery film, comedy film | — |
| Scooby-Doo | 2 | — | — |
| Scratch Fusion | — | boss game, platform game | — |
| Scribblenauts | 6 | puzzle video game | — |
| SD Gundam G Generation | 2 | mecha video game | — |
| Secret Files | 5 | adventure video game | — |
| Sega 3D Reprint Archives | 3 | — | — |
| Sega Superstars | 4 | crossover fiction | — |
| Sega Worldwide Soccer | 2 | association football video game | — |
| Senran Kagura | 12 | action game | — |
| Sentinel Girls | 2 | shoot 'em up, tower defense, side-scrolling video game, dystopian fiction, shooter game | Playism |
| Serious Sam | 34 | first-person shooter | Gathering of Developers, Devolver Digital, 1C Company, Take-Two Interactive |
| Sexy Airlines | 2 | casual game, business simulation game, incremental game, erotic video game | Playduction |
| Sexy Poker | 1 | strip poker video game | — |
| Seymour | 1 | platform game | Codemasters |
| Shadow Hearts | 4 | role-playing video game | Midway Games, Universal Entertainment, Xseed Games |
| Shadow Warrior | 2 | first-person shooter | — |
| Shadowgrounds | 3 | shoot 'em up | — |
| Shadowrun | 3 | science fantasy video game | — |
| Shantae | 6 | action-adventure game, platform game | — |
| Shenmue | 4 | action-adventure game | — |
| Shin Hayarigami | 3 | horror video game, urban fantasy video game, adventure video game, visual novel | Nippon Ichi Software |
| Shin Megami Tensei: Devil Children | 4 | tactical role-playing game, puzzle video game, role-playing video game | — |
| Shin Nippon Pro Wrestling Toukon Retsuden | 4 | professional wrestling video game | — |
| Shine Post | 1 | — | — |
| Shining | 20 | role-playing video game | — |
| Shovel Knight | 2 | puzzle video game, platform game, fighting game | — |
| Silent Hill | 13 | survival horror | Konami Digital Entertainment, Konami |
| Silent Hunter | 6 | submarine simulator | — |
| Silfade series | — | adventure video game, role-playing video game | — |
| Silver Falls | 2 | survival horror, third-person shooter | Sungrand Studios |
| SimCity | 21 | construction and management simulation, strategy, city-building game | Broderbund |
| Simon the Sorcerer | 7 | crossover fiction, adventure video game | — |
| Simple DS Series | 4 | adventure video game | D3 Publisher |
| Simple Wii Series | — | adventure video game | D3 Publisher |
| SingStar | 10 | music video game, party video game | Sony Interactive Entertainment |
| Siren | 3 | psychological horror fiction | Sony Interactive Entertainment |
| Sister Princess | 1 | comedy anime and manga | — |
| Skate | 4 | skateboarding video game | Electronic Arts |
| Ski Jump International | 3 | ski jumping video game | — |
| Ski Jumping | 3 | ski jumping video game | Ringier Axel Springer Polska |
| Skullgirls | 2 | 2D fighting game | Z Intermediate Global Corporation, Marvelous, Arc System Works, Konami, Autumn Games, Skybound Games, CyberFront |
| Skylanders | 5 | action-adventure game | — |
| Slave Maker | 3 | eroge, parody video game | — |
| Slender | 5 | psychological horror fiction | — |
| Slime | 3 | action-adventure game | — |
| Slime Rancher | 2 | biological simulation video game | — |
| Sly Cooper | 6 | platform game, stealth game | Sony Interactive Entertainment |
| Sniper Elite | 11 | tactical shooter, third-person shooter, stealth game | — |
| SNK vs. Capcom | 1 | crossover fiction | — |
| SNK vs. Capcom: Card Fighters Clash | 3 | crossover fiction, collectible card video game | SNK |
| Snooper Troops | 1 | adventure video game | — |
| Snow Bros. | 5 | — | — |
| SOCOM U.S. Navy SEALs | 10 | third-person shooter | — |
| Sodium | 1 | massively multiplayer online game | — |
| Soldam | 2 | falling block puzzle game | — |
| Soldier of Fortune | 3 | first-person shooter | — |
| Sonic Blast Man | 2 | beat 'em up | — |
| Sonic the Hedgehog | 56 | — | — |
| Sorcery! | 5 | interactive fiction | Inkle |
| Sorority Sex Kittens | 1 | pornographic film | — |
| Soulcalibur | 10 | 3D fighting game | Namco |
| Sound Novel | — | sound novel, adventure video game | Chunsoft |
| Sound Voltex | 7 | music video game | Konami |
| South Scrimshaw | 2 | speculative evolution, science fiction video game, mockumentary, visual novel | — |
| Space (series) | — | science fiction video game, role-playing video game | Edu-Ware |
| Space Channel 5 | 3 | music video game | — |
| Space Empires | 4 | space opera video game | — |
| Space Harrier | 4 | shoot 'em up | — |
| Space Impact | 1 | shoot 'em up | Nokia |
| Space Invaders | 5 | shoot 'em up | — |
| Space Marshals | 3 | — | — |
| Space Quest | 7 | space opera video game, adventure video game | — |
| Spec Ops | 7 | — | 2K |
| Spectrobes | 3 | action role-playing game, science fiction video game | Disney Interactive Studios |
| Spectromancer series | 3 | speculative fiction | Apus Software |
| Speed Racing Ultimate | 5 | racing video game | Dream-Up |
| Speedball | 1 | sports video game | — |
| Spider-Man | 3 | — | Sony Interactive Entertainment |
| Spirit | 1 | animated film, adventure film, adventure television series | — |
| Splatoon | 5 | post-apocalyptic video game, third-person shooter | — |
| Splatterhouse | 5 | hack and slash, survival horror, beat 'em up | Namco |
| Spy Fox | 4 | adventure video game | — |
| SSX | 3 | sports video game | — |
| Star Fox | 9 | shoot 'em up, action-adventure game | Nintendo |
| Star Ocean | 9 | space opera video game, action role-playing game, Japanese role-playing video game | Square Enix |
| Star Soldier | 6 | shoot 'em up | Hudson Soft |
| Star Wars: Battlefront | 5 | space opera video game, first-person shooter, third-person shooter | Disney Interactive Studios, Electronic Arts |
| Star Wars: Jedi Knight | 5 | first-person shooter, third-person shooter | Lucasfilm Games |
| Star Wars: Knights of the Old Republic | 11 | space opera video game, action role-playing game | — |
| Star Wars: Rogue Squadron | 3 | action game | — |
| Star Wars: X-Wing | 16 | space combat simulation game | Disney Interactive Studios, Lucasfilm Games |
| StarCraft | 6 | real-time strategy | — |
| StarCraft II | 1 | real-time strategy, military science fiction | Blizzard Entertainment |
| Starstrike | 2 | shooter game | — |
| State of War (Game Series) | 3 | real-time strategy, science fiction video game | — |
| Steak and Jake | 2 | — | — |
| Steel Battalion | 3 | mech simulation game | — |
| Steel Panthers | 4 | tactical wargame | Strategic Simulations |
| Stickman Soccer | — | association football video game | — |
| Stoked Rider | 1 | snowboarding video game | — |
| Stone Protectors | 1 | side-scrolling video game | Kemco |
| Stories of Submission | 2 | erotic video game, visual novel | Zee Vital |
| Story of Eroolia | 1 | otome game, visual novel | — |
| Story of Seasons | 29 | farming simulation game, business simulation game, life simulation game, Japanese role-playing video game | Marvelous, Winning Entertainment Group, Xseed Games |
| Strategic Command | 1 | turn-based strategy video game | — |
| Strider | 5 | — | Capcom |
| Strike | 5 | shoot 'em up | — |
| Strike Witches | 1 | — | — |
| Strip Poker | 1 | strip poker video game | Artworx |
| Strong Bad's Cool Game for Attractive People | 5 | graphic adventure game | Telltale Games |
| Stronghold | 7 | simulation video game, real-time strategy | 1C Company, Take-Two Interactive, 2K, Firefly Studios |
| Submachine | — | point-and-click adventure | — |
| Sucker for Love | 3 | romance video game | — |
| Suikoden | 6 | role-playing video game | — |
| Super Chinese | 4 | beat 'em up, role-playing video game | — |
| Super Mario Advance | 4 | platform game | Nintendo |
| Super Real Mahjong | 7 | mahjong video game | — |
| Super Robot Wars | 24 | tactical role-playing game, crossover fiction | — |
| Super Sidekicks | 3 | association football video game | SNK |
| Super Smash Bros. | 5 | platform fighter, crossover fiction, action game, fighting game | — |
| Super Smash Flash | 2 | fighting game | — |
| Sven Bømwøllen | — | erotic video game | — |
| SWAT | 9 | tactical shooter | — |
| Swedish Erotica | 3 | erotic video game | — |
| Swordquest | 4 | action-adventure game | Atari, Inc. |
| Syberia | 4 | adventure video game | Atari SA |
| Syndicate | 4 | real-time tactics, cyberpunk video game | — |
| Synduality | 1 | — | — |
| Syphon Filter | 7 | action-adventure game, third-person shooter | Sony Interactive Entertainment, 989 Studios |
| System Shock | 1 | first-person shooter | Origin Systems, Electronic Arts, Nightdive Studios |